A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin [0.03%]
一种铜绿假单胞菌PQS集落淬灭系统抑制剂表现出抗葡萄球菌活性并使托布拉霉素敏感型多微生物生物膜失活
Ewan J Murray,Jean-Frédéric Dubern,Weng C Chan et al.
Ewan J Murray et al.
As single- and mixed-species biofilms, Staphylococcus aureus and Pseudomonas aeruginosa cause difficult-to-eradicate chronic infections. In P. aeruginosa, pseudomonas quinolone (PQS)-dependent quorum sensing regulates virulence and biofilm ...
Metabolic incorporation of electron-rich ribonucleosides enhances APEX-seq for profiling spatially restricted nascent transcriptome [0.03%]
富电子核糖核苷的代谢掺入增强了APEX-seq以表征空间限制的新生转录组的能力
Ran Li,Zhongyu Zou,Wentao Wang et al.
Ran Li et al.
The spatial arrangement of newly synthesized transcriptome in eukaryotic cells underlies various biological processes including cell proliferation and differentiation. In this study, we combine metabolic incorporation of electron-rich ribon...
Resurfaced ZIKV EDIII nanoparticle immunogens elicit neutralizing and protective responses in vivo [0.03%]
复活的ZIKV EDIII纳米颗粒免疫原体液中产生中和及保护性抗体响应
George I Georgiev,Ryan J Malonis,Ariel S Wirchnianski et al.
George I Georgiev et al.
Zika virus (ZIKV) is a flavivirus that can cause severe disease, but there are no approved treatments or vaccines. A complication for flavivirus vaccine development is the potential of immunogens to enhance infection via antibody-dependent ...
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease [0.03%]
强效、可穿透细胞的无偏专一性蛋白酶抑制剂BOS-318可改善囊性纤维化呼吸道疾病的主要特征
Lisa E J Douglas,James A Reihill,Melisa W Y Ho et al.
Lisa E J Douglas et al.
In cystic fibrosis (CF), excessive furin activity plays a critical role in the activation of the epithelial sodium channel (ENaC), dysregulation of which contributes to airway dehydration, ineffective mucociliary clearance (MCC), and mucus ...
Kellie D Nance,Supuni Thalalla Gamage,Md Masud Alam et al.
Kellie D Nance et al.
Synthetic messenger RNA (mRNA) is an emerging therapeutic platform with important applications in oncology and infectious disease. Effective mRNA medicines must be translated by the ribosome but not trigger a strong nucleic acid-mediated im...
Victoria Jeffers,Matthew A Child
Victoria Jeffers
Acetyl-coenzyme A is an important metabolite and regulates diverse cellular processes, including metabolism and epigenetics. In this issue of Cell Chemical Biology, Summers et al. (2022) describe an essential parasite enzyme, acetyl-coenzym...
Two birds, one stone: Non-canonical therapeutic effects of the PARP inhibitor Talazoparib [0.03%]
一举两得：PARP抑制剂Talazoparib的非经典治疗作用
Sridevi Challa,W Lee Kraus
Sridevi Challa
In this issue of Cell Chemical Biology, Palve et al. (2022) identified PARP16 as a non-canonical therapeutic target of the PARP1 inhibitor talazoparib, which synergizes with the WEE1 inhibitor adavosertib to enhance its efficacy. The dual t...
Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4 [0.03%]
鸟苷酸还原酶的磷酸化触发EPHA4从促癌功能到抑癌功能的GTP依赖性转换
David W Wolff,Zhiyong Deng,Anna Bianchi-Smiraglia et al.
David W Wolff et al.
Signal transduction pathways post-translationally regulating nucleotide metabolism remain largely unknown. Guanosine monophosphate reductase (GMPR) is a nucleotide metabolism enzyme that decreases GTP pools by converting GMP to IMP. We obse...
Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells [0.03%]
一种内质网蛋白质稳态调节剂可增强胰岛β细胞的胰岛素生成能力
Masato Miyake,Mitsuaki Sobajima,Kiyoe Kurahashi et al.
Masato Miyake et al.
Perturbation of endoplasmic reticulum (ER) proteostasis is associated with impairment of cellular function in diverse diseases, especially the function of pancreatic β cells in type 2 diabetes. Restoration of ER proteostasis by small molec...
Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples [0.03%]
生成靶向因子V/Va的抗凝血适配器并破坏FVa与膜的相互作用（针对正常人和新冠肺炎患者样本）
Erin E Soule,Haixiang Yu,Lyra Olson et al.
Erin E Soule et al.
Coagulation cofactors profoundly regulate hemostasis and are appealing targets for anticoagulants. However, targeting such proteins has been challenging because they lack an active site. To address this, we isolate an RNA aptamer termed T18...