A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease
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In cystic fibrosis (CF), excessive furin activity plays a critical role in the activation of the epithelial sodium channel (ENaC), dysregulation of which contributes to airway dehydration, ineffective mucociliary clearance (MCC), and mucus obstruction. Here, w... ...
