Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells [0.03%]
靶向VPS41诱导肿瘤细胞methuosis并抑制自噬
Yue Liu,Yong Sun,Yuliang Xu et al.
Yue Liu et al.
The homotypic fusion and vacuole protein sorting (HOPS) complex mediates membrane trafficking involved in endocytosis, autophagy, lysosome biogenesis, and phagocytosis. Defects in HOPS subunits are associated with various forms of cancer, b...
Investigation of osteoclast cathepsin K activity in osteoclastogenesis and bone loss using a set of chemical reagents [0.03%]
运用一系列化学试剂研究破骨细胞溶酶体蛋白酶Cathepsin K在破骨细胞分化及骨丢失中的作用
Tomasz Janiszewski,Sonia Kołt,Izabela Ciastoń et al.
Tomasz Janiszewski et al.
Cathepsin K (CatK) is a lysosomal cysteine protease whose highest expression is found in osteoclasts, which are the cells responsible for bone resorption. Investigations of the functions and physiological relevance of CatK have often relied...
Pharmacological management of disease by overcoming structural adversity [0.03%]
通过克服结构上的困难进行药物治疗疾病管理
Richard N Sifers
Richard N Sifers
In this issue of Cell Chemical Biology, Sun et al. utilize computational and protein expression analyses, plus pharmacological proteostasis network activation, to simultaneously correct two genetic diseases linked to a single protein rather...
RAMIHM generates fully human monoclonal antibodies by rapid mRNA immunization of humanized mice and BCR-seq [0.03%]
RAMIHM通过快速mRNA免疫人源化小鼠和BCR-seq生成完全的人源单克隆抗体
Ping Ren,Lei Peng,Luojia Yang et al.
Ping Ren et al.
As a clinical vaccine, lipid nanoparticle (LNP) mRNA has demonstrated potent and broad antibody responses, leading to speculation about its potential for antibody discovery. Here, we developed RAMIHM, a highly efficient strategy for develop...
Fernando Salgado-Polo,Razvan Borza,Minos-Timotheos Matsoukas et al.
Fernando Salgado-Polo et al.
Autotaxin (ATX; ENPP2) produces the lipid mediator lysophosphatidic acid (LPA) that signals through disparate EDG (LPA1-3) and P2Y (LPA4-6) G protein-coupled receptors. ATX/LPA promotes several (patho)physiological processes, including in p...
Inhibitors of the ATPase p97/VCP: From basic research to clinical applications [0.03%]
ATP酶p97 / VCP的抑制剂：从基础研究到临床应用
Susan Kilgas,Kristijan Ramadan
Susan Kilgas
Protein homeostasis deficiencies underlie various cancers and neurodegenerative diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most of the protein degradation in mammalian cells and, therefore, represent a...
Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis [0.03%]
ATF6通过增强蛋白质稳态捕捉到抗胰蛋白酶的致病折叠转换过程
Shuhong Sun,Chao Wang,Pei Zhao et al.
Shuhong Sun et al.
Genetic variation in alpha-1 antitrypsin (AAT) causes AAT deficiency (AATD) through liver aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung manifesting as chronic obstructive pulmonary disease (COPD...
Clearance of plasma PCSK9 via the asialoglycoprotein receptor mediated by heterobifunctional ligands [0.03%]
通过异双功能配体介导的去唾液酸蛋白受体清除血浆PCSK9
Jeffrey T Bagdanoff,Thomas M Smith,Martin Allan et al.
Jeffrey T Bagdanoff et al.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting the degradation of hepatic LDL receptors (LDLRs). Current therapeutic approaches use antibodies that disr...
LRP-1 links post-translational modifications to efficient presentation of celiac disease-specific T cell antigens [0.03%]
LRP-1连接了蛋白翻译后修饰与有效呈现乳糜泻特异性T细胞抗原的关系
Elise Loppinet,Harrison A Besser,Agnele Sylvia Sewa et al.
Elise Loppinet et al.
Celiac disease (CeD) is an autoimmune disorder in which gluten-derived antigens trigger inflammation. Antigenic peptides must undergo site-specific deamidation to be presentable to CD4+ T cells in an HLA-DQ2 or -DQ8 restricted manner. While...
The impact of iron and heme availability on the healthy human gut microbiome in vivo and in vitro [0.03%]
铁和血红素的可用性对健康人体肠道微生物群的影响——体内与体外研究
Arianna I Celis,David A Relman,Kerwyn Casey Huang
Arianna I Celis
Responses of the indigenous human gut commensal microbiota to iron are poorly understood because of an emphasis on in vitro studies of pathogen iron sensitivity. In a study of iron supplementation in healthy humans, we identified gradual mi...