MICU1 controls the sensitivity of the mitochondrial Ca2+ uniporter to activators and inhibitors [0.03%]
MICU1控制线粒体Ca2+单向器对激活剂和抑制剂的敏感性
Macarena Rodríguez-Prados,Kai-Ting Huang,Katalin Márta et al.
Macarena Rodríguez-Prados et al.
Mitochondrial Ca2+ homeostasis loses its control in many diseases and might provide therapeutic targets. Mitochondrial Ca2+ uptake is mediated by the uniporter channel (mtCU), formed by MCU and is regulated by the Ca2+-sensing gatekeeper, M...
Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism [0.03%]
小分子MHC-II诱导剂通过编辑癌症代谢促进免疫识别和抗癌免疫响应
Ling Huang,Jun Zhang,Bo Wei et al.
Ling Huang et al.
Lack of MHC-II is emerging as a causal factor in cancer immune evasion, and the development of small-molecule MHC-II inducers is an unmet clinical need. Here, we identified three MHC-II inducers, including pristane and its two superior deri...
Peter Finin,R M Naseer Khan,Sangmi Oh et al.
Peter Finin et al.
Mycobacterium tuberculosis (Mtb), perhaps more than any other organism, is intrinsically appealing to chemical biologists. Not only does the cell envelope feature one of the most complex heteropolymers found in nature1 but many of the inter...
Respire or expire-precision killing of Helicobacter pylori by targeting complex I respiration [0.03%]
呼吸还是_EXPIRE-通过作用于复杂I呼吸精准杀死幽门螺旋杆菌
Ryan T Fansler,Luisella Spiga,Madison Langford et al.
Ryan T Fansler et al.
In this issue of Cell Chemical Biology, Lettl et al.1 identify complex I as a suitable target for selective killing of Helicobacter pylori. The unique composition of complex I in H. pylori enables precision targeting of the carcinogenic pat...
Zhangping Xiao,Janine L Gray,Edward W Tate
Zhangping Xiao
In this issue of Cell Chemical Biology, Zhan et al. report dual-pharmacophore molecules ("artezomibs"), combining an artemisinin and proteasome inhibitor that exhibit potent activity against both wild-type and drug-resistant malarial parasi...
Philip J Rosenthal
Philip J Rosenthal
Among promising targets for new antimalarials is the Plasmodium falciparum proteasome. Multiple inhibitors have demonstrated potent antimalarial activity and synergy with artemisinins. Potent irreversible peptide vinyl sulfones offer synerg...
Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis [0.03%]
识别结构多样性的FSP1抑制剂以使癌细胞对铁死亡敏感化
Joseph M Hendricks,Cody E Doubravsky,Eddie Wehri et al.
Joseph M Hendricks et al.
Ferroptosis is a regulated form of cell death associated with the iron-dependent accumulation of phospholipid hydroperoxides. Inducing ferroptosis is a promising approach to treat therapy-resistant cancer. Ferroptosis suppressor protein 1 (...
Human nuclear hormone receptor activity contributes to malaria parasite liver stage development [0.03%]
核激素受体活性影响人体肝细胞内疟原虫的发育
Nimisha Mittal,Chadwick Davis,Peter McLean et al.
Nimisha Mittal et al.
Chemical genetic approaches have had a transformative impact on discovery of drug targets for malaria but have primarily been used for parasite targets. To identify human pathways required for intrahepatic development of parasite, we implem...
Anaerobic purinolytic enzymes enable dietary purine clearance by engineered gut bacteria [0.03%]
厌氧嘌呤裂解酶使工程改造的肠道细菌能够清除饮食中的嘌呤
Yang Tong,Yifeng Wei,Yingjie Ju et al.
Yang Tong et al.
Uric acid, the end product of purine degradation, causes hyperuricemia and gout, afflicting hundreds of millions of people. The debilitating effects of gout are exacerbated by dietary purine intake, and thus a potential therapeutic strategy...
Characterization of an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase to treat Candida albicans infections [0.03%]
一种异构别构抑制子表征用于治疗白色念珠菌感染的真菌特异性C-24固醇甲基转移酶
Xueyang Jin,Xuben Hou,Xue Wang et al.
Xueyang Jin et al.
Filamentation is an important virulence factor of the pathogenic fungus Candida albicans. The abolition of Candida albicans hyphal formation by disrupting sterol synthesis is an important concept for the development of antifungal drugs with...