Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA [0.03%]
通过选择性地在病毒和细胞RNA上的m6A表观遗传修饰、擦除和读取来改变抗病毒的先天免疫反应
Caroline J Aufgebauer,Katherine M Bland,Stacy M Horner
Caroline J Aufgebauer
Viral infection and the antiviral innate immune response are regulated by the RNA modification m6A. m6A directs nearly all aspects of RNA metabolism by recruiting RNA-binding proteins that mediate the fate of m6A-containing RNA. m6A control...
Recognition of the tRNA structure: Everything everywhere but not all at once [0.03%]
tRNA结构的识别：无处不在但并非同时发生的一切
Jinwei Zhang
Jinwei Zhang
tRNAs are among the most abundant and essential biomolecules in cells. These spontaneously folding, extensively structured yet conformationally flexible anionic polymers literally bridge the worlds of RNAs and proteins, and serve as Rosetta...
Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response [0.03%]
BTB E3连接酶KEAP1的双价抑制剂可实现NRF2的瞬时激活以抑制急性炎症反应
Mengchen Lu,Jianai Ji,Yifei Lv et al.
Mengchen Lu et al.
Most BTB-containing E3 ligases homodimerize to recognize a single substrate by engaging multiple degrons, represented by E3 ligase KEAP1 dimer and its substrate NRF2. Inactivating KEAP1 to hinder ubiquitination-dependent NRF2 degradation ac...
One-pot trimodal mapping of unmethylated, hydroxymethylated, and open chromatin sites unveils distinctive 5hmC roles at dynamic chromatin loci [0.03%]
一步三模定位未甲基化、羟甲基化和开放染色质位点揭示了动态染色质位点上5hmC的独特作用
Kotryna Skardžiūtė,Kotryna Kvederavičiūtė,Inga Pečiulienė et al.
Kotryna Skardžiūtė et al.
We present a method, named Mx-TOP, for profiling of three epigenetic regulatory layers-chromatin accessibility, general DNA modification, and DNA hydroxymethylation-from a single library. The approach is based on chemo-enzymatic covalent ta...
A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis [0.03%]
一个同时作用于琥珀酸脱氢酶和F1Fo-ATP合成酶的抑制剂可快速杀灭复制型和非复制型结核分枝杆菌
Cara Adolph,Chen-Yi Cheung,Matthew B McNeil et al.
Cara Adolph et al.
Mycobacterial bioenergetics is a validated target space for antitubercular drug development. Here, we identify BB2-50F, a 6-substituted 5-(N,N-hexamethylene)amiloride derivative as a potent, multi-targeting bioenergetic inhibitor of Mycobac...
Development of an intracellular quantitative assay to measure compound binding kinetics [0.03%]
开发用于测量化合物结合动力学的细胞内定量测定方法
Charles S Lay,Daniel A Thomas,John P Evans et al.
Charles S Lay et al.
Published Erratum
Cell chemical biology. 2023 Dec 21;30(12):1692. DOI:10.1016/j.chembiol.2023.12.001 2023
A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV-infected cells [0.03%]
组蛋白去乙酰化酶网络调节HIV感染细胞的表观遗传重编程和病毒沉默
Jackson J Peterson,Catherine A Lewis,Samuel D Burgos et al.
Jackson J Peterson et al.
A long-lived latent reservoir of HIV-1-infected CD4 T cells persists with antiretroviral therapy and prevents cure. We report that the emergence of latently infected primary CD4 T cells requires the activity of histone deacetylase enzymes H...
Luyao Kevin Xu,Panagiotis Ntziachristos
Luyao Kevin Xu
EP300/CBP are histone acetyltransferases recruited onto chromatin by oncogenic transcription factors and control the transcriptional program via their activity in enhancer areas. In the December issue of Cancer Cell, Nicosia et al.1 offer n...
Tag, you're it: G-ICAT identifies p120-cysteine glutathionylation triggering E-cadherin destabilization [0.03%]
标签，你被标记了：G-ICAT确定了触发E-钙粘蛋白不稳定性的p120-半胱氨酸谷胱甘肽化
Kevin T Fridianto,Yimon Aye
Kevin T Fridianto
Current methods have limited ability in directly quantifying the extent of glutathionylation on specific protein-cysteines. In this issue of Cell Chemical Biology, Ahn et al.1 report G-ICAT (glutathione-based isotope-coded affinity tag), ai...
A game of networks: Do different lipids interact to orchestrate inflammatory homeostasis? [0.03%]
网络制胜：不同的脂质相互作用以调控炎症稳态？
Alessandro Leuti,Marina Fava,Mauro Maccarrone
Alessandro Leuti
Resolution of inflammation is the physiological process whereby endogenous pro-resolving lipids constrain inflammatory stimuli that would otherwise cause chronic inflammation. In this issue of Cell Chemical Biology, Peltner et al.1 report t...