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A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV-infected cells

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A long-lived latent reservoir of HIV-1-infected CD4 T cells persists with antiretroviral therapy and prevents cure. We report that the emergence of latently infected primary CD4 T cells requires the activity of histone deacetylase enzymes HDAC1/2 and HDAC3. Da... ...