Megan Ken
Megan Ken
In this Stories piece, Megan Ken, a Fellow at The Scripps Research Institute, discusses the importance of inclusion, mentoring, and creativity to discovery and growth in science. ...
Mo' m1A, mo' problems [0.03%]
更多的m1A, 更多的问题
Linamarie Miller,James Shorter
Linamarie Miller
CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al.1 identify a writer and eraser of N1-methyladenosine (m1A) modifications of CAG-repeat RNA. They establis...
Ling-Ling Chen,Nicholas T Ingolia,Megan L Insco et al.
Ling-Ling Chen et al.
In the first of many thematic issues marking the 30th anniversary of Cell Chemical Biology, we highlight the contribution of chemical biology to RNA biology in a special issue on RNA modulation. We asked several leaders in the field to shar...
Bioorthogonal click labeling of an amber-free HIV-1 provirus for in-virus single molecule imaging [0.03%]
无需琥珀酸的HIV-1前病毒的生物正交点击标记用于病毒内单分子成像
Yuanyun Ao,Jonathan R Grover,Levi Gifford et al.
Yuanyun Ao et al.
Structural dynamics of human immunodeficiency virus 1 (HIV-1) envelope (Env) glycoprotein mediate cell entry and facilitate immune evasion. Single-molecule FRET using peptides for Env labeling revealed structural dynamics of Env, but peptid...
The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond [0.03%]
NLRP1和氧化TRX1之间相互作用涉及一个瞬时二硫键
Michael B Geeson,Jeffrey C Hsiao,Lydia P Tsamouri et al.
Michael B Geeson et al.
NLRP1 is an innate immune receptor that detects pathogen-associated signals, assembles into a multiprotein structure called an inflammasome, and triggers a proinflammatory form of cell death called pyroptosis. We previously discovered that ...
Regulation of bacterial gene expression by non-coding RNA: It is all about time! [0.03%]
非编码RNA对细菌基因表达的调控：一切都与时间有关！
Adrien Chauvier,Nils G Walter
Adrien Chauvier
Commensal and pathogenic bacteria continuously evolve to survive in diverse ecological niches by efficiently coordinating gene expression levels in their ever-changing environments. Regulation through the RNA transcript itself offers a fast...
Causes, functions, and therapeutic possibilities of RNA secondary structure ensembles and alternative states [0.03%]
RNA二级结构集和替代状态的成因、功能及治疗可能
Ritwika Bose,Irfana Saleem,Anthony M Mustoe
Ritwika Bose
RNA secondary structure plays essential roles in encoding RNA regulatory fate and function. Most RNAs populate ensembles of alternatively paired states and are continually unfolded and refolded by cellular processes. Measuring these structu...
Discovery of a PROTAC degrader for METTL3-METTL14 complex [0.03%]
靶向降解METTL3-METTL14复合体的PROTAC降解剂的发现
Wenhao Du,Yuting Huang,Xiaoai Chen et al.
Wenhao Du et al.
N6-methyladenosine (m6A) methylation is the most abundant type of RNA modification that is mainly catalyzed by the METTL3-METTL14 methyltransferase complex. This complex has been linked to multiple cancers and is considered a promising ther...
An acyl-CoA thioesterase is essential for the biosynthesis of a key dauer pheromone in C. elegans [0.03%]
一个酰基-CoA硫酯酶对于C.elegans虫的最关键群聚信息素的生物合成是必不可少的
Subhradeep Bhar,Chi-Su Yoon,Kevin Mai et al.
Subhradeep Bhar et al.
Methyl ketone (MK)-ascarosides represent essential components of several pheromones in Caenorhabditis elegans, including the dauer pheromone, which triggers the stress-resistant dauer larval stage, and the male-attracting sex pheromone. Her...
Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system [0.03%]
发现可抑制结核分枝杆菌ESX-1分泌系统的双效激活乙硫异烟胺增强剂
Raphael Gries,Jason Chhen,Edeltraud van Gumpel et al.
Raphael Gries et al.
Drug-resistant Mycobacterium tuberculosis (Mtb) remains a major public health concern requiring complementary approaches to standard anti-tuberculous regimens. Anti-virulence molecules or compounds that enhance the activity of antimicrobial...