Phase IIb Trial for the Palliative Treatment of Patients With Primary Hepatic Malignancy Unable to Receive Curative Treatment: Efficacy of Colchicine [0.03%]
秋水仙碱治疗不能进行根治性治疗的原发性肝癌患者的IIb期临床试验：疗效分析
Zu-Yau Lin,Ming-Lun Yeh,Po-Cheng Liang et al.
Zu-Yau Lin et al.
This trial was to evaluate the efficacy and the safety of colchicine for the palliative treatment of patients with primary hepatic malignancy unable to receive curative treatment. Forty hepatocellular carcinoma (HCC) patients and two intrah...
Loganin, an Iridoid Glycoside, Alleviates Paclitaxel-Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence [0.03%]
白桦内酯通过增强线粒体功能，提高抗氧化能力，减少细胞衰老来缓解紫杉醇引起的骨骼肌毒性
Yu-Fan Chuang,Cai-Rong Wu,Wan-Hsuan Chang et al.
Yu-Fan Chuang et al.
Mitochondrial dysfunction and energy imbalance caused by chemotherapy are key contributors to skeletal muscle atrophy, which severely impacts the quality of life in cancer patients. Paclitaxel, a commonly used chemotherapeutic agent, is kno...
Clinical Outcomes of Different Generation EGFR TKIs in Susceptible EGFR-Mutated Advanced Nonsmall-Cell Lung Cancer [0.03%]
表皮生长因子受体突变阳性的晚期非小细胞肺癌的不同代EGFR TKI临床疗效分析
Chia-Yu Kuo,Tien-Chi Huang,Chih-Jen Yang et al.
Chia-Yu Kuo et al.
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are indicated for advanced lung adenocarcinoma patients harboring susceptible EGFR mutations. The aim of this retrospective study was to compare the effectiveness of ...
In Vitro Evaluation of the Inhibitory Effects of Linarin on Histamine-Induced Expression of Proinflammatory Cytokines, Mucin 5AC, and Aquaporin 5 in Human Nasal and Bronchial Epithelial Cells [0.03%]
黄环素对组胺诱导的原代培养人鼻黏膜和气管上皮细胞炎性因子、MUC5AC及AQP5表达的影响研究
Xin-Jing Mi,Jie Wang,Jian-Qiang Qi
Xin-Jing Mi
Allergic rhinitis and asthma are two prevalent chronic allergic conditions in children. Linarin, a glycosylated flavonoid derived from various plants, exhibits a wide range of biological activities. This study aimed to investigate the thera...
Albumin-Bilirubin Score as a Novel Prognostic Prediction Tool for Surgically Treated Head and Neck Squamous Cell Carcinoma [0.03%]
白蛋白-胆红素分级作为头颈部鳞状细胞癌手术治疗预后预测的新工具
Ming-Hsien Tsai,Chao-Hui Yang,Yu-Tsai Lin et al.
Ming-Hsien Tsai et al.
We investigated the prognostic significance of the preoperative albumin-bilirubin (ALBI) score in surgically treated head and neck squamous cell carcinoma (HNSCC). This retrospective study included 663 patients who underwent radical surgery...
Vitexin Attenuates the Growth and Glycolysis of Acute Myeloid Leukemia Cells by Suppressing the HIF-1α-Modulated YAP Pathway Under Hypoxic Conditions [0.03%]
缺氧条件下半边莲素通过抑制HIF-1α调节的YAP信号通路抑制急性髓系白血病细胞生长和糖酵解
Ping Wang,Jia-Jia Zhang,Fang Zhang et al.
Ping Wang et al.
Vitexin, an apigenin flavone glycoside, exhibits antitumor activity against various cancers including leukemia. Hypoxia enhances glycolysis, thereby promoting tumor growth. In this study, we aimed to explore the effects of vitexin on hypoxi...
Clinical Outcomes in Patients With T4b Esophageal Squamous Cell Carcinoma: A 10-Year Single Institution Experience [0.03%]
T4b期食管鳞癌患者的临床结局：单中心十年回顾
Yi-Hsun Chen,Wen-Hung Hsu,I-Chen Wu et al.
Yi-Hsun Chen et al.
Esophageal squamous cell carcinoma (ESCC) with adjacent structure invasion (T4b), affecting areas such as the aorta, vertebral body, or trachea, is associated with a poor prognosis, and the optimal treatment strategy remains unclear. While ...
Involvement of the miR-128-3p/KDM3A/NLRP3 Axis in High Glucose-Induced Inflammatory Injury in Retinal Endothelial Cells [0.03%]
高血糖诱导的视网膜内皮细胞炎症损伤中miR-128-3p/KDM3A/NLRP3轴的作用机制研究
Wei-Ming Wen,Jian-Bo Feng,Yin-Sheng Cai et al.
Wei-Ming Wen et al.
This study explores the regulatory mechanism of the miR-128-3p in diabetic retinopathy (DR)-associated inflammatory injury. A cellular model of DR was established by inducing immortalized human retinal endothelial cells (IM-HRECs) with high...
HOXA5 Suppresses NEK7-Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A [0.03%]
HOXA5通过转录抑制KAT2A抑制急性肺损伤中的肺泡上皮细胞焦亡
Lei Wang,Heng Fan,Qi Wang et al.
Lei Wang et al.
Alveolar epithelial cell pyroptosis exacerbates inflammation and tissue damage by releasing inflammatory mediators, thereby promoting the development of acute lung injury (ALI). However, the fundamental mechanism underlying alveolar epithel...
Regulatory Effect and Mechanism of Tanshinone I on Cell Apoptosis in Steroid-Induced Osteonecrosis of the Femoral Head [0.03%]
丹参酮Ⅰ对糖皮质激素诱导的股骨头坏死细胞凋亡的作用及机制研究
Qing Su,Jia Chen
Qing Su
Steroid-induced osteonecrosis of the femoral head (SIONFH) is a debilitating orthopedic condition. This study investigated the mechanism of Tanshinone I (TsI) in SIONFH modulating apoptosis in SIONFH via the PI3K/AKT/mTOR pathway. A SIONFH ...