Jonas Mumenthaler,Maximilian Feldmann,Shahab Mamaghani et al.
Jonas Mumenthaler et al.
Synthetic mRNA produced by in vitro transcription is the active pharmaceutical ingredient of approved vaccines and of many drugs under development. It typically contains a 3' poly(A) tail required for optimal stabilization and translation o...
Preliminary Evaluation of the Virtual Reality-Based Gait Sensory Interaction Test (GaitSIT) for Quantifying Sensory Reweighting During Walking Balance [0.03%]
基于虚拟现实的步态感觉交互测试（GaitSIT）的初步评估，用于量化行走平衡期间的感觉重新加权
Priyo Ranjan Kundu Prosun,Shafique Chaudhry,Masudul H Imtiaz et al.
Priyo Ranjan Kundu Prosun et al.
Background: Walking is a dynamic activity that relies on inputs from the multisensory system, i.e., somatosensory, vision, and vestibular. These inputs are processed and integrated in the central nervous system to produce motor impulses for...
Selection and Characterization of Cell Line-Virus Pairs for Sensitive Viral Detection Assays in Biopharmaceutical Testing [0.03%]
用于生物药病毒检测的细胞系-病毒组合的选择与鉴定
Agnieszka Staniszewska,Agnieszka Piastowska-Ciesielska
Agnieszka Staniszewska
Ensuring viral safety is a critical aspect of biopharmaceutical production, requiring sensitive and reliable methods for detecting adventitious agents. In this study, we systematically evaluated the performance of selected cell line-virus c...
Simplified and Rapid Preparation Protocol for Producing Aloe Vera-Based Natural Coagulant for Water Treatment [0.03%]
促进芦荟凝絮剂快速制备的简易方案
Danieli Soares de Oliveira,Clainer Bravin Donadel
Danieli Soares de Oliveira
Natural coagulants have emerged as potential alternatives to synthetic chemicals in water treatment, especially for decentralized and low-resource applications. However, many previously reported Aloe vera-based coagulant preparation methods...
An Improved Method for the Isolation of Extrachromosomal DNA from the Pathogenic Free-Living Amoeba Naegleria fowleri [0.03%]
从致病自由生活的变形虫Naegleria fowleri中分离染色体外DNA的改进方法
Colm P Roster,James C Morris
Colm P Roster
The pathogenic free-living amoeba Naegleria fowleri is the cause of primary amebic meningoencephalitis (PAM), a central nervous system infection that is almost always lethal. One of the unusual features of the amoebae is the presence of ~40...
Lyubov A Rzhanova,Ekaterina V Kuzmenko,Alena A Permyakova et al.
Lyubov A Rzhanova et al.
Background: This study focuses on developing a model of a non-healing wound that recapitulates the pathogenesis of the corresponding human pathology. Methods: A non-healing wound was modeled in mice with streptozotocin-induced diabetes. The...
Standardized Protocol for Comprehensive, Non-Invasive Phenotyping of Atrial Myopathy in Sprague-Dawley Rat Models of Metabolic Syndrome Using Clinical-Grade Echocardiography and Electrophysiology Systems [0.03%]
采用临床级超声心动图和电生理系统对代谢综合征Sprague-Dawley大鼠模型心房肌病进行全面无创表型分析的标准协议
Ardian Rizal,Mohammad Saifur Rohman,Fatchiyah Fatchiyah et al.
Ardian Rizal et al.
Background: Small animal models are essential for atrial fibrillation (AF) research. Researchers in AF use an electrocardiogram (ECG), echocardiography and invasive electrophysiology study (EPS) to assess atrial structural and electrical re...
Izabela Antepowicz,Antonia Despotidi,Emma Rowan et al.
Izabela Antepowicz et al.
Daphnids, commonly known as water fleas, are freshwater planktonic microcrustacean species used as model organisms in ecotoxicology, particularly in regulatory frameworks that adhere to OECD and ISO standards. Mortality is the most common e...
Evaluating Effectiveness of the FiTeens Intervention for Health Behavior Change in Students: A Study Protocol [0.03%]
针对学生健康行为改变的FiTeens干预效果评价研究方案
Taavi Rand,Henri Tilga,Ángel Abós et al.
Taavi Rand et al.
(1) Background: Previous school-based interventions have addressed adolescent health behaviors such as physical activity, screen time, and sleep, but have predominantly targeted these behaviors independently rather than simultaneously. The ...
An Efficient TetR/TetO-Integrated Packaging System for Fowl Adenovirus 4 Vector Carrying Toxic Transgene [0.03%]
一种高效的 tetronica 启动系统用于携带毒性转基因的鸡腺病毒4载体包装系统
Qian-Wen Ma,Zhi Li,Zhi-Chao Zhang et al.
Qian-Wen Ma et al.
Adenoviral vectors are widely used for gene therapy and vaccine development. To circumvent pre-existing immunity against commonly used human adenovirus type 5, vectors based on rare human serotype or animal adenoviruses have attracted incre...