Jingwen Yu,Yiqi Zhao,Yue Xie
Jingwen Yu
Lung cancer is a leading cause of cancer-related death, and the most common type of lung cancer is non-small cell lung cancer, which accounts for approximately 85 % of lung cancer diagnoses. Recent studies have revealed that ubiquitination ...
Modulation of ACE2/Ang1-7/Mas and ACE/AngII/AT1 axes affects anticancer properties of sertraline in MCF-7 breast cancer cells [0.03%]
ACE2/Ang1-7/Mas和ACE/AngⅡ/AT1轴的调节影响五氟利多在MCF-7乳腺癌细胞中的抗癌特性
Reihaneh Fatehi,Mohammad Nouraei,Morteza Panahiyan et al.
Reihaneh Fatehi et al.
The renin-angiotensin system (RAS) is best known for playing a major role in maintaining the physiology of the cardiovascular system. Dysregulation of the RAS pathway has been proposed as a link to some malignancies and contributes to cance...
Attenuation of PI3K/AKT signaling pathway by Ocimum gratissimum leaf flavonoid-rich extracts in streptozotocin-induced diabetic male rats [0.03%]
Ocimum gratissimum叶黄酮富集提取物通过削弱PI3 K/Akt信号途径改善链脲佐菌素致雄性大鼠糖尿病的机理研究
Basiru Olaitan Ajiboye,Courage Dele Famusiwa,Monsurah Oluwaseyifunmi Amuda et al.
Basiru Olaitan Ajiboye et al.
Diabetes is a group of medical conditions characterized by the body's inability to effectively control blood glucose levels, due to either insufficient insulin synthesis in type 1 diabetes or inadequate insulin sensitivity in type 2 diabete...
Epigenome editing revealed the role of DNA methylation of T-DMR/CpG island shore on Runx2 transcription [0.03%]
DNA甲基化调控T-DMR/ CpG岛岸序列对Runx2转录的作用及机制研究
Yutaro Kawa,Miyuki Shindo,Jun Ohgane et al.
Yutaro Kawa et al.
RUNX2 is a transcription factor crucial for bone formation. Mutant mice with varying levels of Runx2 expression display dosage-dependent skeletal abnormalities, underscoring the importance of Runx2 dosage control in skeletal formation. RUNX...
Correlation of calpain sensitivity, Bradford assay instability, and electrophoretic mobility in phosphomimetic mutants of GlyT2 N-terminus [0.03%]
GlyT2 N端磷酸模拟突变体的钙蛋白酶敏感性、低丰度蛋白质定量的不稳定性以及电泳迁移率之间的相关性分析
Martina Baliova,Frantisek Jursky
Martina Baliova
The glycine transporter GlyT2 plays an important role in glycine-inhibitory neurotransmission of the hindbrain and spinal cord. Its special feature is the extended N-terminus, which contains a large number of potentially phosphorylated seri...
Nabil Eid,Md Abdul Alim Al-Bari
Nabil Eid
A prediction of the CRNDE role by modulating NF-κB pathway in inflammatory bowel disease (IBD) [0.03%]
预测长链非编码RNA CRNDE通过调节NF-κB通路参与炎症性肠病(IBD)发病机制的作用
Nesa Kazemifard,Maryam Farmani,Shaghayegh Baradaran Ghavami et al.
Nesa Kazemifard et al.
Long non-coding RNAs (lncRNAs) regulate multiple pathways and cellular mechanisms. Recent research has emphasized their involvement in the pathogenesis of complex diseases, such as Inflammatory Bowel Disease (IBD) which is characterized by ...
Vibrational spectroscopic detection of radiation-induced structural changes in Chironomus hemoglobin [0.03%]
应用振动光谱法检测辐射引起的Chironomus血红蛋白的结构变化
Pallavi S Gaikwad,Arti Hole,Vibha Saxena et al.
Pallavi S Gaikwad et al.
Purpose: Chironomus hemoglobin is known to exhibit higher gamma radiation resistance compared to human hemoglobin. In the present study, we have introduced a sensitive method to analyze radiation-induced alterations in Ch...
T790M mutation sensitizes non-small cell lung cancer cells to radiation via suppressing SPOCK1 [0.03%]
T790M突变通过抑制SPOCK1增强非小细胞肺癌放射敏感性
Yasi Xu,Pengjun Zhao,Xiao Xu et al.
Yasi Xu et al.
Background: Approximately 50% of patients harbor the T790M mutation after developing first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance. Evidence has showed the major treatme...
Unveiling the molecular basis of paracetamol-induced hepatotoxicity: Interaction of N-acetyl- p-benzoquinone imine with mitochondrial succinate dehydrogenase [0.03%]
水杨酸肝毒性分子机制的研究：N-乙酰对苯醌亚胺与线粒体琥珀酸脱氢酶的相互作用
Md Sahadot Hossen,Adiba Akter,Mahir Azmal et al.
Md Sahadot Hossen et al.
Background and aim: N-acetyl-p-benzoquinoneimine (NAPQI), a toxic byproduct of paracetamol (Acetaminophen, APAP), can accumulate and cause liver damage by depleting glutathione and forming protein adducts in the mitochond...