Epigenome editing revealed the role of DNA methylation of T-DMR/CpG island shore on Runx2 transcription
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RUNX2 is a transcription factor crucial for bone formation. Mutant mice with varying levels of Runx2 expression display dosage-dependent skeletal abnormalities, underscoring the importance of Runx2 dosage control in skeletal formation. RUNX2 activity is regula... ...
