Circular RNA circPSEN1 promotes neovascularization by regulating the miR-150-5p/TRIM65 axis in diabetic retinopathy [0.03%]
Circular RNA circPSEN1通过调控miR-150-5p/TRIM65轴促进糖尿病视网膜病变新生血管化
Dongyu Cai,Shouquan Lu,Yujue Wang
Dongyu Cai
Diabetic retinopathy (DR), a major microvascular complication of diabetes, is a leading cause of vision loss. Neovascularization is a hallmark of DR, and circRNA-PSEN1 (circPSEN1) has emerged as a key regulator in its development. However, ...
Human umbilical cord mesenchymal stem cell exosomes inhibit proliferation and promote apoptosis in an in vitro model of keloid [0.03%]
人脐带间充质干细胞外泌体通过体外瘢痕疙瘩模型的增殖抑制和促凋亡作用发挥抗瘢痕功效
Wenjing Han,Jinjia Cui,Zijun Zhou et al.
Wenjing Han et al.
Background: Keloid is a pathologic scar formation resulting from trauma, burns, surgery, or unknown causes, leading to deformity and varying degrees of functional impairment, significantly impacting the physical and menta...
Overexpression of DYRK1A in down syndrome: Analysis of kinase activity [0.03%]
唐氏综合症中DYRK1A的过度表达：激酶活性分析
Wieslaw K Dowjat,Yu-Wen Hwang
Wieslaw K Dowjat
DYRK1A (dual-specificity tyrosine phosphorylation regulated kinase 1A) is known to play critical roles in regulating numerous cellular functions like cell cycle, neuronal development, and immune homeostasis. Altered expression DYRK1A is imp...
The effect of liposomal ellagic acid on the biological properties of dental restorative materials: An in vitro comparative study [0.03%]
姜黄素对四种窝沟封闭剂材料细胞毒性、抑菌性和热机械疲劳度的影响：体外实验研究
Maryam Rezaeianjam,Mohammad Hossein Yazdanpanah,Zahra Mohsenpour et al.
Maryam Rezaeianjam et al.
This study investigated whether incorporating liposomal ellagic acid (LEA) could enhance the biological performance of two common dental restorative materials. LEA nanoparticles were synthesized and applied (10 μg/mL) to nano-glass ionomer...
Metabolic phenotype and patient characteristics associate with inter-donor variability of osteogenic differentiation in human adipose stem cells [0.03%]
人脂肪干细胞成骨分化的个体差异与代谢表型和患者特征相关性研究
Abdus Sattar,Justus P Beier,Tim Ruhl
Abdus Sattar
Adipose-derived stem/stromal cells (ASCs) are promising candidates for bone tissue engineering due to their abundance, accessibility, and osteogenic differentiation capacity. However, substantial inter-donor variability limits their standar...
Abdulla Al Mamun Bhuyan,Md Ashraf Zaman Faruk,Md Niamot Ali et al.
Abdulla Al Mamun Bhuyan et al.
Tasisulam, an acyl-sulfonamide compound, is being investigated in clinical trials for the treatment of several malignancies, including non-small cell lung cancer, lymphoma, breast cancer, melanoma, ovarian cancer, colon cancer, and other so...
Serum metabolomic profiling identifies a biomarker panel associated with age-related hearing loss [0.03%]
血清代谢组学鉴定出与年龄相关听力损失相关的生物标志物组合
Hongshun Wang,Hairong Shi,Hao Zhang et al.
Hongshun Wang et al.
Age-related hearing loss (ARHL) is a progressive neurodegenerative disorder for which reliable biomarkers are lacking. This study aimed to identify serum metabolic markers associated with ARHL that may improve early screening and diagnostic...
Vibrio parahaemolyticus AHPND infection altered eicosanoid biosynthesis in the gastrointestinal tract of Litopenaeus vannamei [0.03%]
副溶血性弧菌AHPND感染改变了Litopenaeus vannamei肠道环氧脂肪酸生物合成路径
Wananit Wimuttisuk,Pisut Yotbuntueng,Pacharawan Deenarn et al.
Wananit Wimuttisuk et al.
Acute Hepatopancreatic Necrosis Disease (AHPND) is one of the main culprits for massive shrimp mortality in the aquaculture industry. AHPND is caused by Vibrio parahaemolyticus (VPAHPND) containing plasmids for the PirA and PirB binary toxi...
CEACAM5 drives psoriatic inflammation by regulating CD8+ T cell recruitment and activation [0.03%]
CEACAM5通过调节CD8⁺T细胞募集和活化驱动银屑病炎症反应
Lifeng Wang,Xiaotao Liu,Kaina Cao et al.
Lifeng Wang et al.
As a chronic relapsing immune-mediated skin disorder, psoriasis is mainly driven by CD8+ T cells during disease progression, while the molecular basis of CD8+ T cell recruitment and activation in psoriatic lesions remains largely unclear, a...
Lactobacillus helveticus GCL1815 induces Th1-skewing T-cell responses via dendritic cell activation [0.03%]
乳酸菌通过激活树突状细胞诱导T细胞偏向Th1应答
Yuma Matsumoto,Keisuke Yamane,Keigo Tsuruno et al.
Yuma Matsumoto et al.
Recent studies have highlighted how the immunomodulatory effects of probiotics act through dendritic cell (DC) activation. Evaluation of their in vivo efficacy requires understanding their strain-specific functions, the magnitude of their a...