LncRNA GAS5 regulates osteogenic differentiation of human periodontal ligament stem cells through miR-23b-3p/STAT5B axis [0.03%]
长链非编码RNA GAS5通过miR-23b-3p/STAT5B轴调控人牙周膜干细胞成骨分化
Qiufang Zhang,Yan Huang,Liping Huang et al.
Qiufang Zhang et al.
Periodontal ligament stem cells (PDLSCs) play a crucial role in alveolar bone regeneration due to their inherent osteogenic differentiation capacity. However, the molecular mechanisms regulating PDLSC osteogenic differentiation remain incom...
Dynamic modulation of N6-methyladenosine by ionizing radiation in human cells [0.03%]
电离辐射动态修饰人类细胞中的N6-甲基腺苷酸
L Cruz-Garcia,Philip Davies,Veronika Goriacha et al.
L Cruz-Garcia et al.
A cell's transcriptome is regulated through the integration of external and internal signals that activate intracellular signal pathways, epigenetic modifications and post-translational changes. Post-transcriptional regulation through RNA m...
Preventive and inhibitory effects of Salacia on sustained contraction of vascular smooth muscle cells and characterization of the active compounds [0.03%]
含希莶草的草药配方防治血管平滑肌细胞持续收缩及活性成分研究
Katsuko Kajiya,Hiroki Inokuchi,Yumemi Sakakibara et al.
Katsuko Kajiya et al.
Sustained contraction of vascular smooth muscles can abruptly restrict blood flow, leading to ischemia. While mild, prolonged contractions may cause dizziness and migraines, severe vasoconstriction (vasospasm) can result in cerebral or myoc...
EWSR1 as a regulatory target in hepatic stellate cell apoptosis and liver fibrosis therapy [0.03%]
EWSR1在肝星状细胞凋亡及肝纤维化治疗中的调控作用研究
Zhang Shiwan,Luo Guangcheng,Maisarah Abdul Mutalib
Zhang Shiwan
Liver fibrosis is a progressive condition driven by hepatic stellate cell (HSC) activation and resistance to apoptosis, culminating in excessive extracellular matrix (ECM) accumulation and organ dysfunction. Current antifibrotic therapies r...
Investigating the consequences of tape-stripping in ovalbumin-induced allergic mouse model: From physiology to gene regulation [0.03%]
探究脱毛对卵清蛋白致敏小鼠模型影响：从生理到基因调控
Yuan Zhao,Xinhua Zhang,Jing Tian et al.
Yuan Zhao et al.
Background: Food allergy is a growing global health concern, with increasing prevalence and significant impacts on patients quality of life. Epithelial barrier dysfunction, particularly through the skin-gut axis, has emer...
Dual-transferred atmospheric-pressure plasma jet modulates matrix metalloproteinase expression in breast cancer stem cells [0.03%]
双转移大气压等离子体射流调节乳腺癌干细胞中基质金属蛋白酶的表达
Abolfazl Soulat,Taghi Mohsenpour,Leila Roshangar
Abolfazl Soulat
Breast cancer stem cells (BCSCs) are a highly aggressive subpopulation, driving tumor initiation, metastasis, and therapeutic resistance, largely through matrix metalloproteinases (MMPs)-mediated extracellular matrix remodeling. Here, we in...
Unmani Sidor,Graham M Hughes,Jeremy C Simpson
Unmani Sidor
Rab GTPases are essential regulators of membrane trafficking with known roles in neurodegeneration, cancer progression and metastasis. While individually, Rabs have been extensively studied in disease and phylogenetic contexts, the overall ...
Human milk oligosaccharides promote synaptogenesis and neurite outgrowth in human cortical organoids [0.03%]
人乳寡糖促进人类皮层类器官中的突触发生和神经突生长
Luisa Bulcão V C,Natalia C S Moreira,Paulo C Carvalho et al.
Luisa Bulcão V C et al.
The first 1000 days of a child's life represent a critical window for brain development, during which nutrition exerts profound effects on the trajectories of neurodevelopment. Human Milk Oligosaccharides (HMOs), a major component of human ...
Emodin inhibits breast tumorigenesis in the comorbidity of hyperlipidemia and associated with IL-17 suppression [0.03%]
蒽酚通过抑制IL-17信号通路抑制高脂血症条件下乳腺肿瘤的发生发展
Qingqing Liu,Lujing Zheng,Chuangpeng Li et al.
Qingqing Liu et al.
Background: This study explored the interaction between breast cancer and the hyperlipidemia microenvironment, and assessed the anti-tumorigenic effects of the natural compound Emodin. ...
Directed evolution of Clec12a-binding peptides using mammalian-expressed recombinant protein [0.03%]
利用哺乳动物表达的重组蛋白对Clec12a结合肽进行定向进化
Yoshirou Kawaguchi,Md Samiul Islam,Mina Yokoyama et al.
Yoshirou Kawaguchi et al.
Clec12a is an immunoregulatory C-type lectin receptor expressed on dendritic cells as well as other myeloid cells, and involved in maintaining immune homeostasis. Unlike many other C-type lectin receptors that promote immune activation, Cle...