Single-cell transcriptome sequencing revealing the microenvironment of breast fibroepithelial tumor [0.03%]
单细胞测序揭示乳腺纤维上皮肿瘤微环境
Tianrun Shu,Jing Wang,Fuying Yang et al.
Tianrun Shu et al.
Background: Giant juvenile fibroepithelial tumors of the breast are rare lesions that mainly affect adolescent girls. Their pathogenesis is poorly understood, and current management relies almost entirely on surgery, whic...
Bifendate inhibits cell PARthanatos by activating the MEK/ERK pathway [0.03%]
毕赤双倒专题抑制PARthanatos通过激活MEK/ERK途径
Ao-Meng Hu,Meng Chen,Can-Can Zhu et al.
Ao-Meng Hu et al.
PARthanatos is a form of programmed cell death increasingly implicated in neurodegenerative diseases and ischemic stroke. Although classical PARP-1 inhibitors can interrupt this pathway, their prolonged use carries a risk of genomic instabi...
Methanogenic activities signatures in broilers fed black soldier fly (Hermetia illucens) larvae-based diets [0.03%]
鸡粪中黑兵蝇(Hermetia illucens)幼虫基于饮食的甲烷生成活动痕迹
Deborah Oluwaferanmi Ibiwoye,Opeyemi Adetola Oladejo,Oluwatomisin Aderonke Akinsola et al.
Deborah Oluwaferanmi Ibiwoye et al.
Methanogenic archaea in the avian gut contribute to hydrogen turnover and thus play a role in fermentative efficiency and greenhouse gas emission. While black soldier fly larvae meal (BSFLM) has been explored as a replacement for fishmeal i...
Heat-induced antigen retrieval by using Tris-EDTA solution destroys nuclear structure in certain tissues [0.03%]
采用Tris-EDTA溶液进行热诱导抗原修复法可破坏某些组织的核结构
Haizhen Wang,Xingyi Luo,Xian Qiang et al.
Haizhen Wang et al.
Tris-EDTA buffer (pH 9.0) is widely used for heat-induced antigen retrieval (HIAR) in immunohistochemistry due to its high efficiency. However, it remains unclear whether Tris-EDTA is equally suitable for all tissues and for the detection o...
Integrated bioinformatics and tissue-based validation reveal the oncogenic role of hsa_circ_0043256 and hsa_circ_0004789 in gastric cancer [0.03%]
整合生物信息学和组织基验证揭示胃癌中hsa_circ_0043256和hsa_circ_0004789的致癌作用
Somayeh Aslani,Ashkan Kalantary-Charvadeh,Pejman Morovat et al.
Somayeh Aslani et al.
Circular RNAs (circRNAs) play a key role in gastric cancer (GC) pathogenesis. This study hsa_circ_0043256 and hsa_circ_0004789, and their interactions with miR-28-5p/Cyclin B1 (CCNB1) and miR-5683/CCNB1, via bioinformatic and experimental m...
Regulation of ferroptosis in colorectal cancer through therapeutic modulation and miRNA targeting [0.03%]
通过治疗调节和miRNA靶向调控结直肠癌中铁死亡的作用
Ali Ahmadizad Firouzjaei,Seyed Hamid Aghaee-Bakhtiari,Samira Mohammadi-Yeganeh
Ali Ahmadizad Firouzjaei
Colorectal cancer (CRC) is a highly prevalent disease that represents a major global health burden. Ferroptosis has gained significant attention in recent years as a potential target for cancer therapy. Meanwhile, microRNAs (miRNAs) have em...
The role of metformin in extracellular matrix-based three-dimensional cell culture Models: A mini-review on therapeutic potentials [0.03%]
二甲双胍在基于细胞外基质的三维细胞培养模型中的作用：对治疗潜力的综述研究
Mahshid Zamani,Nepton Soltani
Mahshid Zamani
Metformin, a widely used antidiabetic agent, exhibits pleiotropic effects extending beyond glycemic control, including the modulation of the extracellular matrix (ECM). Although traditional two-dimensional (2D) cell cultures have provided f...
Hibiscus sabdariffa calyx aqueous extract mitigates alcohol withdrawal-induced anxiety and oxidative stress in mice [0.03%]
罗望子萼片提取物缓解酒精戒断引起的焦虑和氧化应激作用研究
Nadège Emégam Kouémou,Louis Aimé Sepi,Mireille Sylviane Nguepi Dongmo et al.
Nadège Emégam Kouémou et al.
Background: Alcohol withdrawal syndrome (AWS) happens following a sudden interruption of chronic alcohol intake. AWS is a severe condition, often leading to anxiety and seizures. Current treatments against AWS do not targ...
Computational analysis of the structural and functional impact of the deleterious nsSNPs in the human F2R gene and their implications in glioma [0.03%]
人类F2R基因有害nsSNPs的结构和功能影响的计算分析及其在胶质瘤中的意义
Saif Mukramoon Arosh,Md Raiyan Hosen,Md Ismail Hosen et al.
Saif Mukramoon Arosh et al.
The protease-activated receptor 1 (PAR1) protein, derived from the F2R gene, is integral to various physiological and pathological mechanisms and has been recognized as an oncogene in multiple studies, playing a crucial role in the aggressi...
Comparative effects of a TLR7/8 agonist and doxorubicin on immune checkpoint modulation and apoptosis in 4T1 breast cancer cells [0.03%]
TLR7/8激动剂和多柔比星对4T1乳腺癌细胞免疫检查点调节和凋亡的比较效应
Nazanin Joudaki,Mohsen Tehrani,Abolghasem Ajami et al.
Nazanin Joudaki et al.
Background: Breast cancer is still one of the challenges of medical science, despite fast and remarkable advancements in diagnosis and new therapy approaches. This study aims to explore the individual effects of TLR7/8 ag...