Appropriate threshold setting and multiple methods combination may improve reproducibility of gene ontology enrichment analysis [0.03%]
Qi Guo,Tian Fu,Na Wang et al.
Qi Guo et al.
Transcriptome analyses are widely used for biological research. Gene ontology (GO) enrichment analysis is often used for effectively analyzing large data matrices. However, various software and methods can be used for performing GO enrichme...
Oroxylin A ameliorates hepatic steatosis and non-alcoholic fatty liver disease through the regulation of CPT1A m6A methylation in hepatocytes [0.03%]
Yihong Ji,Han Gu,Mingyue Wang et al.
Yihong Ji et al.
Non-alcoholic fatty liver disease (NAFLD) is a chronic condition that is frequently observed worldwide and has become a threat to global public health. Excess accumulation of hepatic lipids contributes to NAFLD. Oroxylin A has attracted wid...
ECM (collagen) mediated signaling drives the emergence of androgen independence in prostate cancer cells [0.03%]
Apoorva Abikar,Prathibha Ranganathan
Apoorva Abikar
Extracellular matrix is a major structural component of the tumor microenvironment. It is a dynamic entity that undergoes continuous deposition, remodeling and degradation to maintain tissue homeostasis. ECM plays crucial roles in providing...
Immune profiling of T cells: A comparative analysis of single-cell TCR sequencing using 10X Genomics and Parse Biosciences platforms [0.03%]
Nanna Kristjánsdóttir,Kasper Thorsen,Nicolai J Birkbak et al.
Nanna Kristjánsdóttir et al.
Single-cell RNA sequencing (scRNA-seq) is a powerful tool for characterising the immune landscape. Multiple technologies are available, each with distinct specificities and inherent biases. Here, we focus on two technologies-10X Genomics an...
Multivariate analysis and ADME profiling of Rosmarinus officinalis L. leaf vs. stem extracts: Extraction method-driven bioactivity and pharmacokinetic implications [0.03%]
Fatima-Zahrae Ed-Darraz,Saida Tayibi,Sana Mounaimi et al.
Fatima-Zahrae Ed-Darraz et al.
This study evaluated the bioactive potential of Rosmarinus officinalis L. extracts obtained separately from leaves and stems, comparing maceration (ME), Soxhlet (SE), and ultrasound-assisted extraction (UAE) techniques. Phytochemical profil...
Granzyme B-expressing regulatory B cells share the same origin as conventional blood B cells [0.03%]
Steve Genebrier,Nicolas Sailliet,Samuel Bastos Serra Trinca et al.
Steve Genebrier et al.
Regulatory B cells (Bregs) play a pivotal role in various dysimmune conditions. We have previously demonstrated that granzyme B-expressing (GZMB+) B cells are more numerous in patients with graft tolerance following kidney transplantation a...
Comprehensive analysis of mutational signatures and corresponding driver genes in cervical cancer from Xinjiang [0.03%]
Chaoyang Chen,Wenbo Zhao,Min Guo et al.
Chaoyang Chen et al.
Objective: To investigate the mutational characteristics of cervical cancer in Xinjiang and their relationships with tumor driver genes and affected signaling pathways. ...
Differential metabolic responses to hydrogen peroxide-induced oxidative stress in parotid and submandibular gland acinar cell lines [0.03%]
Golnaz Golnarnik,Anni I Nieminen,Tine M Søland et al.
Golnaz Golnarnik et al.
This study explored how oxidative stress induced by hydrogen peroxide alters metabolite levels in submandibular and parotid salivary gland acinar cells. We investigated the impact of oxidative stress on the metabolite profiles of two saliva...
Characterization of a novel inherited splice-site variant in MAPK8IP3 expands the genetic and phenotypic spectrum of neurodevelopmental disorders [0.03%]
Sheng Yi,Qi Yang,Xiong Song et al.
Sheng Yi et al.
Background: The MAPK8IP3 gene encodes JIP3, a kinesin-1 adapter protein crucial for axonal transport and JNK signaling pathway regulation. This gene exhibits extreme intolerance to loss-of-function variants. Heterozygous ...
Zhenzhen Zhao,Karla F Díaz Rodríguez,Andrea A E Mendez et al.
Zhenzhen Zhao et al.
Copper (Cu) is an essential micronutrient that serves as a cofactor for redox enzymes but becomes toxic when unregulated. In bacteria, while Cu efflux systems are well characterized, mechanisms of Cu import remain poorly understood. Here, w...