GRB2: A dynamic adaptor protein orchestrating cellular signaling in health and disease [0.03%]
GRB2：一种动态适应蛋白，在健康和疾病中协调细胞信号转导
Francesca Malagrinò,Elena Puglisi,Livia Pagano et al.
Francesca Malagrinò et al.
GRB2, or Growth Factor Receptor-Bound Protein 2, is a pivotal adaptor protein in intracellular signal transduction pathways, particularly within receptor tyrosine kinase (RTK) signaling cascades. Its crystal structure reveals a modular arch...
Rosolic acid as a novel activator of the Nrf2/ARE pathway in arsenic-induced male reproductive toxicity: An in silico study [0.03%]
罗氏酸作为砷诱导的男性生殖毒性的Nrf2/ARE途径的新激活剂：一种计算机模拟研究
Anirban Goutam Mukherjee,Abilash Valsala Gopalakrishnan
Anirban Goutam Mukherjee
Male reproductive toxicity as a result of arsenic exposure is linked with oxidative stress and excessive generation of reactive oxygen species (ROS). It leads to an imbalance between ROS production and antioxidant defense mechanisms ultimat...
Unconventional localization of PAI-1 in PML bodies: A possible link with cellular growth of endothelial cells [0.03%]
PAI-1在PML体中的非典型定位：与内皮细胞生长的可能联系
Pragya Gehlot,Daniela Brünnert,Vibha Kaushik et al.
Pragya Gehlot et al.
Plasminogen activator inhibitor-1 (PAI-1/Serpin E1) is classically known for its antifibrinolytic activity via inhibiting uPA and tPA of the fibrinolytic pathway. PAI-1 has a paradoxical role in tumor progression, and its molecular function...
Single-cell transcriptomic analysis of immune cell dynamics in the healthy human endometrium [0.03%]
健康人体子宫内膜免疫细胞动态的单细胞转录组分析
Kaixing Chen,Qiaoni Yu,Qing Sha et al.
Kaixing Chen et al.
The microenvironment of the endometrial immune system is crucial to the success of placental implantation and healthy pregnancy. However, the functionalities of immune cells across various stages of the reproductive cycle have yet to be ful...
Deciphering the enigmatic PilY1 of Acidithiobacillus thiooxidans: An in silico analysis [0.03%]
嗜硫氧化螺菌PilY1蛋白的分子特征及生理功能的生物信息学研究
Araceli Hernández-Sánchez,Edgar D Páez-Pérez,Elvia Alfaro-Saldaña et al.
Araceli Hernández-Sánchez et al.
Thirty years since the first report on the PilY1 protein in bacteria, only the C-terminal domain has been crystallized; there is no study in which the N-terminal domain, let alone the complete protein, has been crystallized. In our laborato...
Advancing cellular insights: Super-resolution STORM imaging of cytoskeletal structures in human stem and cancer cells [0.03%]
细胞超分辨率STORM成像促进细胞新认识：人类干细胞和癌细胞细胞骨架结构研究
Anupam Bharadwaj,Amalesh Kumar,Sam Padalumavunkal Mathew et al.
Anupam Bharadwaj et al.
Fluorescence microscopy is an important tool for cell biology and cancer research. Present-day approach of implementing advanced optical microscopy methods combined with immunofluorescence labelling of specific proteins in cells is now able...
Membrane-anchored intracellular insulin receptor or insulin-like growth factor-1 receptor elicits ligand-independent downstream signaling [0.03%]
锚定在膜上的胰岛素受体或胰岛素样生长因子-1受体可以独立于配体产生下游信号转导反应
Akiko Sotozono,Kazuhiko Namekata,Xiaoli Guo et al.
Akiko Sotozono et al.
Neurodegenerative diseases including glaucoma affect insulin signaling, and insulin treatment has been shown to reverse the neurodegenerative loss of dendritic complexity in retinal ganglion cells. Therefore, strategies for enhancing or mai...
A comparative study of the substrate preference of the sialidases, CpNanI, HpNanH, and BbSia2 towards 2-Aminobenzamide-labeled 3'-Sialyllactose, 6'-Sialyllactose, and Sialyllacto-N-tetraose-b [0.03%]
唾液酸酶CpNanI，HpNanH和BbSia2作用于2-氨基苯并酰基标记的3'-神经氨酸乳糖，6'-神经氨酸乳糖和神经氨酸乳四糖-b的动力学比较研究
Madhu Lata,T N C Ramya
Madhu Lata
Sialidases catalyze the removal of terminal sialic acids from sialylated biomolecules, and their substrate preference is frequently indicated in terms of the glycosidic linkages cleaved (α2-3, α2-6, and α2-8) without mention of the remai...
Generation of bone-specific lysyl hydroxylase 2 knockout mice and their phenotypes [0.03%]
骨特异性lysyl羟化酶2基因敲除小鼠的制备及其表型研究
Kenta Tsuneizumi,Atsushi Kasamatsu,Tomoaki Saito et al.
Kenta Tsuneizumi et al.
Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of lysine residues in the telopeptides of type I collagen. This modification is critical for the formation of stable hydroxylysine-aldehyde derived collagen cross-links, thus, for the st...
NanoLuciferase technology-based detection of TMPRSS2 as attempt to develop anti-coronavirus agents [0.03%]
基于NanoLuciferase技术检测TMPRSS2以研发抗冠状病毒药物
Yanwen Chen,Yunqi Li,Ye Zhao et al.
Yanwen Chen et al.
•Utilized NanoBiT technology for high-throughput screening.•Identified compounds reducing TMPRSS2 expression, a crucial step for SARS-CoV-2 entry.•Explored a broad range of compound libraries. ...