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Unconventional localization of PAI-1 in PML bodies: A possible link with cellular growth of endothelial cells

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Plasminogen activator inhibitor-1 (PAI-1/Serpin E1) is classically known for its antifibrinolytic activity via inhibiting uPA and tPA of the fibrinolytic pathway. PAI-1 has a paradoxical role in tumor progression, and its molecular functions are poorly underst... ...