Exploring miRNA profile associated with cisplatin resistance in ovarian cancer cells [0.03%]
用于探索顺铂耐药的卵巢癌细胞中miRNA表达谱关联的研究
Yaman Alghamian,Chadi Soukkarieh,Abdulmunim Aljapawe et al.
Yaman Alghamian et al.
Ovarian cancer is a common and lethal malignancy among women, whereas chemoresistance is one of the major challenges to its treatment and prognosis. Chemoresistance is a multifactorial phenomenon, involving various mechanisms that collectiv...
Effect of β-catenin on hypoxia induced epithelial mesenchymal transition in HK-2 cells by regulating Brachyury [0.03%]
CTNNB1通过调控T基因介导的EMT在缺氧诱导的肾小管上皮细胞纤维化中的作用机制研究
Ping Sun,Haihui Yang,Binying Min et al.
Ping Sun et al.
Background: Chronic kidney disease (CKD) has become a worldwide health problem and the incidence rate and mortality of CKD have been rising. Renal fibrosis (RF) is the final common pathological feature of almost all kinds...
Study on metabolic disorders in rat liver induced by different times after scalds [0.03%]
不同烫伤后时间点致大鼠肝脏代谢紊乱的研究
Zhian Chen,Hui Lin,Xixiong Su et al.
Zhian Chen et al.
Previous studies have confirmed that burns and scalds can lead to metabolic disorders in the liver. However, the effects of severe burns at various time points on liver lipid metabolism disorders, as well as the relationship between these d...
Heparin-binding of the human chitinase-like protein YKL-40 is allosterically modified by chitin oligosaccharides [0.03%]
透明质酸的人类半乳糖凝集素CHI3L1(YKL-40)的结合位点受几丁聚糖的影响发生构象变化
Unnur Magnusdottir,Finnbogi R Thormodsson,Lilja Kjalarsdottir et al.
Unnur Magnusdottir et al.
The chitinase-like protein YKL-40 (CHI3L1) has been implicated in the pathophysiology of inflammation and cancer. Recent studies highlight the growing interest in targeting and blocking the activity of YKL-40 to treat cancer. Some of those ...
The effect of platelet-rich plasma on ferroptosis of nucleus pulposus cells induced by Erastin [0.03%]
富血小板血浆对尔拉stin诱导的椎间盘髓核细胞铁死亡的影响
Shi-Lin Lian,Jie Huang,Yan Zhang et al.
Shi-Lin Lian et al.
Background: Intervertebral disc degeneration (IVDD) has been linked to ferroptosis, a type of programmed cell death. The role of platelet-rich plasma (PRP) in mitigating ferroptosis in nucleus pulposus (NP) cells within I...
Investigating combined hypoxia and stemness indices for prognostic transcripts in gastric cancer: Machine learning and network analysis approaches [0.03%]
基于机器学习和网络分析的胃癌预后基因联合缺氧与干细胞指数的研究
Sharareh Mahmoudian-Hamedani,Maryam Lotfi-Shahreza,Parvaneh Nikpour
Sharareh Mahmoudian-Hamedani
Introduction: Gastric cancer (GC) is among the deadliest malignancies globally, characterized by hypoxia-driven pathways that promote cancer progression, including stemness mechanisms facilitating invasion and metastasis....
Bioinformatic identification of signature miRNAs associated with fetoplacental vascular dysfunction in gestational diabetes mellitus [0.03%]
生物信息学鉴定妊娠期糖尿病胎盘血管功能障碍相关的特征性miRNA标志物
Yulan Lu,Chunhong Liu,Xiaoxia Pang et al.
Yulan Lu et al.
Background: Intrauterine exposure to gestational diabetes mellitus (GDM) poses significant risks to fetal development and future metabolic health. Despite its clinical importance, the role of microRNAs (miRNAs) in fetopla...
Xinmu Cui,Yu Song,Jianfeng Han et al.
Xinmu Cui et al.
The Transforming Growth Factor-beta (TGF-β) signaling pathway, with SMAD4 as its central mediator, plays a pivotal role in regulating cellular functions, including growth, differentiation, apoptosis, and immune responses. While extensive r...
Assessing the prevalence of neutralizing antibodies (NAbs) to SARS-CoV-2 during three years of the COVID-19 pandemic [0.03%]
评估COVID-19大流行三年期间SARS-CoV-2中和抗体（NAbs）的流行率
Marina Dos Santos Barreto,Ronaldy Santana Santos,Eloia Emanuelly Dias Silva et al.
Marina Dos Santos Barreto et al.
The development of COVID-19 vaccines has been an important step in the fight against the pandemic. However, it is still necessary to understand the influence of factors that can alter the immune response. In general, doses need to be update...
Spectroscopic and calorimetric study of the interaction between Nile blue and double-stranded RNA [0.03%]
尼莱蓝与双链RNA相互作用的光谱和量热研究
Md Dulal Hossain Khan,Ramya Ayyalasomayajula,Mare Cudic et al.
Md Dulal Hossain Khan et al.
Nile blue has been widely used in histological staining, fluorescence labeling, and DNA probing, with its intercalation behavior into the DNA helix being well documented. Here, we present a comprehensive investigation to address a current k...