Inhibition of FGFR signaling attenuates phosphaturia and early kidney injury in sickle cell disease mice [0.03%]
FGFR信号传导抑制可缓解镰状细胞病小鼠的排磷作用和早期肾脏损伤
Marja M Hurley,Yanlin Wang,Liping Xiao
Marja M Hurley
We examined whether short term treatment with the pan-FGF Receptor (FGFR) inhibitor BGJ398 (Infigratinib) modulated impaired FGFR downstream signaling, phosphate wasting and markers of kidney damage in sickle cell disease (SCD) mice. Health...
Indication of diurnal variations in the rat choroid plexus for cerebrospinal fluid secretion [0.03%]
关于脑脊液生成的日周期变化的指标-大鼠脉络丛的研究
Takeshi Yamaguchi,Toshiyuki Hamada,Toshiyuki Matsuzaki et al.
Takeshi Yamaguchi et al.
The epithelial tissue of the choroid plexus (CP) is responsible for producing cerebrospinal fluid (CSF). The CP possesses a robust circadian clock, suggesting that CSF secretion from the CP is regulated by the circadian clock; however, the ...
Neuroprotective effects of glucotropaeolin as the major glucosinolate of cress seed on cuprizone-induced mouse model of multiple sclerosis [0.03%]
芸苔素葡萄糖苷对类金属化合物致小鼠多发性硬化模型的神经保护作用研究
Masoumeh Bathaee,Mohammad Seyedabadi,Mohammad Shokati Sayyad et al.
Masoumeh Bathaee et al.
Multiple sclerosis (MS) is a neurodegenerative disease characterized by inflammation and myelin damage. Glucosinolates, present in Lepidium sativum L. (garden cress) seeds (LSS), exhibit anti-inflammatory properties. This study evaluates th...
Vitamin D and antimicrobial peptides in skin health and disease: Mechanisms and therapeutic potential [0.03%]
维生素D和抗菌肽在皮肤健康与疾病中的作用机制及治疗潜力
Hanlin Gao,Jianwei Zhu,Zhi Chen et al.
Hanlin Gao et al.
As the body's frontline barrier against the external environment, the skin maintains homeostasis through a complex network of innate defense factors, among which antimicrobial peptides (AMPs) play pivotal roles in pathogen defense, inflamma...
Hui-Deng Long,Ning Zhang,Wen-Er Wang et al.
Hui-Deng Long et al.
As a key tumor suppressor protein, p53 plays a central role in biological processes such as cell cycle regulation, DNA repair, apoptosis, and metabolism. However, p53 gene mutations or functional inactivation are prevalent in over 50% of hu...
Bergapten attenuates oxidative stress and neuroinflammation to promote the survival and neuronal differentiation of neural stem/progenitor cells after ischemic insult [0.03%]
bergapten通过减轻氧化应激和神经炎症促进缺血损伤后神经干细胞/祖细胞的存活和向神经元分化
Zelong Tang,Yannian Li,Yan Gao et al.
Zelong Tang et al.
Background: Ischemic stroke remains a leading cause of death and disability worldwide. A significant challenge in recovery is the hostile microenvironment in the ischemic penumbra, characterized by excessive oxidative str...
Pan-cancer expression, methylation, and prognostic significance of α7 nicotinic acetylcholine receptor in tumor immunology [0.03%]
α7烟碱型乙酰胆碱受体在肿瘤免疫学中的泛癌表达、甲基化及预后意义
Xuehong Bai,Ting Ma,Lei Shi et al.
Xuehong Bai et al.
The α7 nicotinic acetylcholine receptor (α7nAChR), functioning as a critical ligand-gated ion channel in the nervous system, has recently been implicated to play a role in various non-neuronal tissues. Nonetheless, a comprehensive underst...
An exploratory investigation of β-aminoisobutyric acid as a biomarker: possible relationships between urinary BAIBA and lifestyle habits [0.03%]
β-氨基异丁酸作为生物标志物的探索性研究：尿液中BAIBA与生活方式之间的可能关系
Miu Suzuki,Yuki Shimba,Ayana Sakai et al.
Miu Suzuki et al.
Background: β-Aminoisobutyric acid (BAIBA) is a metabolite of valine and thymine and has been identified as a myokine released from skeletal muscle in response to exercise. Experimental studies have suggested that BAIBA ...
RNA-protein complexes as key regulators of plant secondary metabolism: Biophysical interactions and functional significance [0.03%]
RNA-蛋白质复合物作为植物次级代谢的关键调节因子：生物物理相互作用和功能意义
Okechukwu Paul-Chima Ugwu,Melvin Nnaemeka Ugwu,Hope Onohuean et al.
Okechukwu Paul-Chima Ugwu et al.
RNA-protein complexes (RNPs) are central regulators of post-transcriptional gene expression and are increasingly implicated in controlling when, where and to what extent specialised (secondary) metabolic pathways operate in plants. Relative...
Protective effects of three natural extracts on ovalbumin-induced intestinal and skin damage in felines via the gut-skin axis: An in vitro study [0.03%]
三种天然提取物通过肠-皮肤轴对卵清蛋白诱导的猫肠道和皮肤损伤的保护作用：体外研究
Hengyan Wang,Tong Liu,Huasong Bai et al.
Hengyan Wang et al.
The gut-skin axis plays a crucial role in mediating systemic immune and metabolic responses, particularly in allergic disorders. This study investigated the protective effects of three natural extracts-Heartleaf Houttuynia P.E. (HH), green ...