A glycosaminoglycan microarray identifies galectin-4 binding to sulfated glycosaminoglycans [0.03%]
糖胺聚糖微阵列鉴定出半乳糖凝集素-4与硫酸化糖胺聚糖的结合
Kanae Sano,Meri Nagatomo,Katsunobu Shigematsu et al.
Kanae Sano et al.
Lectin-glycosaminoglycan (GAG) interactions remain incompletely understood despite their potential roles in cell signaling and immune regulation. In this study, we performed a comprehensive profiling of the binding specificity of 49 types o...
The role of SUMOylation in regulating proteins that drive neuronal disease progression [0.03%]
SUMO化修饰调控神经源性疾病相关蛋白的功能及其在疾病发生发展中的作用研究
Aditya Sidharth,Daesung Shin
Aditya Sidharth
SUMOylation is a post-translational modification in which a Small Ubiquitin-like Modifier (SUMO) protein is reversibly attached to a lysine residue on a target protein in an ATP-dependent process. This modification can affect the function o...
Plant-derived extracellular vesicles as bioactive nanoplatforms: Biogenesis, therapeutic evidence, and translational challenges [0.03%]
植物源外泌体作为生物活性纳米平台：产生、治疗证据和转化挑战
Jingcheng Yu,Yuren Shen,Hao Jia
Jingcheng Yu
Background: Plant-derived extracellular vesicles (PDEVs) are nanoscale membrane vesicles isolated from edible or medicinal plants. They have attracted interest because they combine endogenous biological activity with the ...
Effects of metformin and exercise on Alzheimer's model induced by D-galactose in the rats: A behavioral, histological and BDNF gene study [0.03%]
二甲双胍和运动对D-半乳糖诱导的AD大鼠模型的行为学、组织病理学及脑源性神经营养因子基因的影响研究
Tahereh Varmazyar,Nasrin Heidariyeh,Shima Ababzadeh
Tahereh Varmazyar
The objective of the current research is to investigate the cognitive performance of male Alzheimer's disease rats in the context of the combined effects of exercise and metformin. The rats were divided into eight different groups. The Morr...
Comparative proteomics of human naso-oropharyngeal swabs from COVID19 patients for identification of potential biomarker candidates [0.03%]
用于识别潜在生物标志物候选者的COVID-19患者的鼻咽拭子的蛋白质组学比较研究
Sabyasachi Bandyopadhyay,Megha Brijwal,Arhaan Haridas et al.
Sabyasachi Bandyopadhyay et al.
COVID19 continues to be a public health issue with subvariants of the main strains causing infections globally. This study looks to identify potential biomarker candidates that can help to understand molecular etio-pathogenesis. Proteins fr...
Salidroside and mesenchymal stem cells alleviate hypobaric hypoxia-induced lung injury and are associated with alterations in the gut-lung axis [0.03%]
红景天苷和间充质干细胞通过改善肺肠轴功能缓解低氧性肺损伤
Dengqin Ma,Bang Xin,Meng Li et al.
Dengqin Ma et al.
High-altitude pulmonary injury (HAPI) results from hypobaric hypoxia and is characterized by excessive inflammation, oxidative imbalance, and disrupted barrier integrity. Salidroside and mesenchymal stem cells (MSCs) have shown protective e...
A colorimetric readout based on the PrestoBlue® dye as an objective method for measuring neutralizing antibodies against influenza virus in human serum samples [0.03%]
基于PrestoBlue染料的色彩读取法作为测量人血清样品中针对流感病毒的中和抗体的一项客观方法
Maria A Stincarelli,Francesca Dapporto,Valentina Biagini et al.
Maria A Stincarelli et al.
Influenza is an infectious respiratory disease that has significant morbidity and a high mortality rate. The immune responses induced against both seasonal and potentially pandemic strains of the influenza virus are of fundamental importanc...
Failure of morphogenesis in chronic inflammation-associated early tumourigenesis: Extracellular matrix biomechanics as an integrative layer [0.03%]
慢性炎症相关早期肿瘤发生过程中形态发生的失败：细胞外基质生物力学作为整合层
Hirotaka Tao
Hirotaka Tao
Chronic inflammation promotes tumourigenesis through both mutation accumulation and persistent failure of tissue repair mechanisms to restore organised three-dimensional architecture. However, current frameworks of inflammation-associated t...
A workflow to reduce red blood cell autofluorescence for imaging IL-4/IL-4R interactions in the inflamed lung [0.03%]
一种减少红细胞自发荧光以对发炎肺部的IL-4/IL-4R相互作用进行成像的工作流程
Cyril Salama,Alexandre Cousin,Myriam Oger et al.
Cyril Salama et al.
Motivation: Autofluorescence is a common challenge in fluorescence microscopy of inflamed tissue, particularly where red blood cell (RBC) autofluorescence can mimic true fluorescence signals. This complicates image interp...
A novel corneal epithelial cell culture assay for assessing topical antivirals against herpes simplex virus keratitis [0.03%]
一种评估局部抗病毒药物治疗单纯疱疹病毒性角膜炎的新型角膜上皮细胞培养检测方法
Hidenobu Kuniyoshi,Yui Numata,Mina Sasano et al.
Hidenobu Kuniyoshi et al.
Various in vitro models have been used to study HSV infection, but corneal epithelial-based assay systems for evaluating antiviral activity remain limited. In this study, we established a in vitro assay of HSV keratitis using the CRL-11516,...