Betanin ameliorates dextran sulfate sodium-induced colitis in mice by modulating tight junction protein expression [0.03%]
甜菜碱通过调节紧密连接蛋白表达改善葡聚糖硫酸钠诱导的小鼠结肠炎
Nichakarn Kwankaew,Hiroaki Okuda,Tatsuya Ishikawa et al.
Nichakarn Kwankaew et al.
The incidence of inflammatory bowel disease (IBD), a chronic inflammatory condition of the gastrointestinal tract characterized by a progressive and unpredictable disease course, has been increasing in many parts of the world. Inflammation ...
The emerging role of machine learning-based methods in cancer classification using microRNA [0.03%]
基于机器学习的微小核糖核酸在癌症分类中的作用
Zeinab Tariri,Mehdi Goodarzi,Atieh Nouralishahi et al.
Zeinab Tariri et al.
Early detection and accurate classification of cancer are crucial to improving patient outcomes. Diagnosis and classification of tumors using conventional methods remains challenging. MicroRNAs (miRNAs) are potential biomarkers for accurate...
Glycolysis-related genes for bladder cancer: A Mendelian randomization analysis [0.03%]
与膀胱癌相关的糖酵解基因：一项梅涅代尔随机化分析研究
Xuwei Hong,Gang Wang,Ting Hong et al.
Xuwei Hong et al.
Background: Glycolysis contributes to tumor progression and treatment resistance in bladder cancer (BLCA). This study aims to identify glycolysis-related genes associated with BLCA risk. ...
Structural and functional characterization of sHsp from the marine cyanobacterium Picosynechococcus sp. NKBG15041c [0.03%]
海洋鱼腥蓝藻Picosynechococcus sp. NKBG15041c中sHsp的结构与功能表征
Mima Ogawa,Wakaba Naka,Ken Morishima et al.
Mima Ogawa et al.
Small heat-shock proteins (sHsps) are ATP-independent chaperones whose oligomerization and client capture are regulated by a conserved C-terminal IXI/V motif. Here, we identify and characterize an sHsp from the marine cyanobacterium Picosyn...
Carica papaya leaf and root extracts attenuate hyperglycemia-induced insulin resistance by modulating MAPK and PI3K/AKT signalling in hepatic and skeletal muscle cells [0.03%]
番木瓜叶和根提取物通过调节肝细胞和骨骼肌细胞的MAPK和PI3K / AKT信号传导来减弱高血糖引起的胰岛素抵抗
Mthokozisi Bongani Nxumalo,Rene Bernadette Khan,Nosipho Ntanzi et al.
Mthokozisi Bongani Nxumalo et al.
Type 2 diabetes mellitus (T2DM) is characterised by impaired glucose homeostasis arising from insulin resistance and inadequate insulin action in peripheral tissues. Carica papaya has been reported to exert antidiabetic effects; however, it...
Lactylation as a metabolic-epigenetic switch: Mechanisms and roles in cancer, sepsis, trauma, inflammation, and tissue repair [0.03%]
代谢表观遗传调控开关乳酰化的机制与功能：癌症、脓毒症、创伤、炎症及组织修复中的乳酰化作用机制和角色研究
David Bar-Or,Kaysie Banton,David Acuna et al.
David Bar-Or et al.
Lactylation, a recently discovered post-translational modification, links cellular metabolism to epigenetic regulation and immune function. Once considered a mere glycolytic byproduct, lactate is now recognized as a signaling metabolite tha...
The development of a methodology to measure primary ciliary length in neural progenitor cells with a target molecule knocked down [0.03%]
一种测量神经前体细胞中靶分子敲低的主要鞭毛长度的测定方法的发展
Masaki Saito,Wataru Otsu,Kenichi Ishibashi et al.
Masaki Saito et al.
The primary cilium is an immotile cellular antenna that extends from the basal body and protrudes from the cell surface during the G0/G1 phases. The cilium is resorbed when it receives growth factor stimuli, and the ciliary resorption trigg...
Investigating the effect of rhubarb (Rheum ribes L.) root and leaf extracts on seed germination timing and early growth parameters: An approach to plant allelopathy [0.03%]
rheum ribes l. 根叶浸提液对农作物种子萌发及幼苗生长影响的研究：植物化感作用的一个实验案例分析
Saeed Sheikh Ali Babaei Mahani,Mohsen Sharafatmandrad,Esfandiar Jahantab
Saeed Sheikh Ali Babaei Mahani
This study evaluated the allelopathic effects of aqueous leaf and root extracts of Rheum ribes L. on two native rangeland species, Stipa barbata Desf. (Poaceae) and Astragalus cyclophyllon G. Beck (Fabaceae), focusing on both germination ti...
β-Hydroxybutyrate attenuates glycation-induced structural destabilization and amyloidogenic aggregation in human serum albumin [0.03%]
β-羟基丁酸盐减轻糖基化引起的人血清白蛋白结构不稳定和淀粉样聚集
Hojjat Mohammadnia,Mousa Bohlooli,Mansour Ghaffari-Moghaddam et al.
Hojjat Mohammadnia et al.
Protein aggregation and amyloid fibril formation are key events in neurodegenerative disorders such as Alzheimer's disease, and are worsened by non-enzymatic glycation, which destabilizes protein structure. Glycation by reducing sugars like...
Anti-cancer effect of palmitic acid against the endometrial cancer progression via inducing ferroptosis [0.03%]
棕榈酸通过诱导铁死亡抑制子宫内膜癌进展
Shuting Lan,Xiaomei Sun,Qiyuan Bo et al.
Shuting Lan et al.
Background: The critical role of metabolic reprogramming as a potential therapeutic target in the management of endometrial cancer (EC) progression requires further investigation. This study investigated the anti-cancer e...