Development and evaluation of a novel experimental autoimmune prostatitis model induced by a prostate-specific antigen mixture in rats [0.03%]
雄性大鼠新型自身免疫性前列腺炎模型的构建及评价
Xuwei Hong,Ting Hong,Xinyu Liu et al.
Xuwei Hong et al.
Objective: To develop a novel experimental autoimmune prostatitis (EAP) model in rats using a prostate-specific antigen (PSA) mixture and to determine the optimal dose by evaluating the dose-dependent effects. ...
Virus-like particles vaccine of porcine epidemic diarrhea virus spike 1 protein induces protective immunity challenge in piglets [0.03%]
猪流行性腹泻病毒S1蛋白类病毒颗粒疫苗诱导断奶仔猪免疫保护力试验
Zhiqiang Li,Jie Li,Jiahai Cheng et al.
Zhiqiang Li et al.
Porcine epidemic diarrhea virus (PEDV) is a highly contagious intestinal disease that impairs piglet growth and development, causing significant economic losses. Therefore, developing an effective vaccine is crucial for preventing and contr...
Coronary endothelial cells receive Notch1 signal during heart development [0.03%]
NOTCH1信号在心脏发育过程中被冠状内皮细胞接受
Yoshitoku Watabe,Satoru Takahashi,Masaharu Yoshihara
Yoshitoku Watabe
The Notch1 signaling pathway, via the Notch1 receptor and its endogenous ligands, has been suggested to play a role in heart development, as mutations in Notch1 and associated genes are associated with abnormal development of the myocardium...
A comprehensive review of Azadirachta indica (Neem): Exploring proximate composition, bioactive compounds, and prospects for antimicrobial activity [0.03%]
全面综述印度槐豆（尼姆）：探讨粗略组成、生物活性化合物及抗菌活性前景
Gunasekaran Priyanka,Thirumugam Gowripriya,Bynedi Seshadhri Chinna Mounish et al.
Gunasekaran Priyanka et al.
Neem, or Azadirachta indica A. Juss., is a tree that is both versatile and native to the Indian subcontinent and Southeast Asia. It is frequently employed in traditional medicine to treat skin issues and pyrexia, as well as for environmenta...
Deciphering synergistic killing mechanisms of capsaicin combined with colistin against colistin-resistant Acinetobacter baumannii through metabolomics analysis [0.03%]
基于代谢组学分析解码辣椒素联合多粘菌素B对抗多粘菌素耐药鲍曼不动杆菌的协同杀菌机制
Mengjie Hou,Liying Yang,Changchao Huan et al.
Mengjie Hou et al.
Colistin is increasingly used as last-line therapy for A. baumannii infections. This has led to the emergence of colistin-resistant strains of A. baumannii. Therefore, exploring novel approaches to fight colistin resistance in A. baumannii ...
Lipidomic analysis of A1, A2, and heterozygous beta-casein genotypes in bovine milk using gas chromatography-mass spectrometry [0.03%]
采用气相色谱-质谱法分析A1、A2型β-酪蛋白基因型奶牛乳脂的脂质组成
Phelipe A B M Peres,Milton J Filho,Hebreia O A Souza et al.
Phelipe A B M Peres et al.
The consumption of A2 milk, which contains only the A2 type of beta-casein, has been increasing because it is considered healthier. In contrast, milk that contains the A1 type of beta-casein may cause gastrointestinal discomfort due to the ...
TRPA1 deficiency alters brown adipose tissue proteome and thermogenic gene expression during cold exposure in mice [0.03%]
TRPA1缺乏通过改变冷暴露的小鼠棕色脂肪组织蛋白质组和产热基因表达发挥产热作用
Cristhian D Sua-Cespedes,Otoniel Gonçalves Lima,Letícia Menezes Vasconcelos et al.
Cristhian D Sua-Cespedes et al.
TRPA1 channels function as cold sensors and have been implicated in energy metabolism. We investigated the impact of TRPA1 on thermoregulation. Trpa1 -/- mice exhibited body weight loss and increased food intake when transitioning from 30°...
Processing enhances the anti-hepatocellular carcinoma effect of Momordicae Semen via remodeling chemical composition and regulating the Akt/mTOR/STAT3 pathway [0.03%]
炮制优化西瓜霜化学成分并调控Akt/mTOR/STAT3信号通路以增效抗肝癌作用
Lei Fang,Mingzhu Liu,Rongrong Han et al.
Lei Fang et al.
Momordicae Semen (MS) is a traditional medicinal herb with reported antitumor potential. However, the impact of processing on its chemical composition and the underlying mechanisms against hepatocellular carcinoma (HCC) remain insufficientl...
Morphodynamic cellular changes prior to and during cell fusion related to osteoclast formation [0.03%]
与破骨细胞形成有关的细胞融合前后的形态动力学变化及细胞变化
Lei Li,Qianfeng Xiang,Wei Ji et al.
Lei Li et al.
Osteoclasts (OCs) play an important role in bone remodeling and bone resorption. Furthermore, OCs are considered to initiate the process of osteoinduction by stimulating the osteogenic differentiation of mesenchymal stromal cells (MSCs). OC...
A regenerative strategy for vital pulp therapy: Platelet-rich fibrin augments stem cell viability and pluripotency in bioactive cement environments [0.03%]
一种再生性策略用于活髓治疗：富血小板纤维素可增强干细胞在生物活性水泥环境中的存活率及多能性
Fatemeh Pourmohammadi-Nejad,Ali Irannezhad,Ramin Abazarpour et al.
Fatemeh Pourmohammadi-Nejad et al.
Background: Vital pulp therapy (VPT) aims to preserve pulp vitality and stimulate regeneration of the dentin-pulp complex. Dental pulp stem cells (DPSCs) are clonogenic mesenchymal stem cells with high self-renewal and mu...