Effect of 6-gingerol on proliferation and apoptosis of ovarian cancer cells by the PI3K/AKT/mTOR pathway [0.03%]
姜辣素通过PI3K/Akt/mTOR信号通路影响卵巢癌细胞增殖和凋亡的作用机制研究
Ai-Ying Guo,Yong-Shuai Chen,Huan Li et al.
Ai-Ying Guo et al.
Background: As a major contributor to mortality among gynecological malignancies, ovarian cancer highlights an urgent need for novel therapeutic approaches. Although 6-gingerol-a primary bioactive compound found in ginger...
Vestibular functional assessment using the caloric test in mice with arsanilic acid-induced vestibular dysfunction [0.03%]
使用冷热试验评估亚砷酸诱导前庭功能损伤小鼠的功能状况
Shotaro Harada,Yoshihisa Koyama,Takao Imai et al.
Shotaro Harada et al.
The vestibular system contributes to postural control, eye movements, spatial perception, and autonomic regulation. Its dysfunction causes vertigo, nausea, postural instability, which gradually improve via central plasticity known as vestib...
Effects of TiO2 nanoparticles on the kinetics and conformation of bovine alkaline phosphatase [0.03%]
TiO2纳米颗粒对牛碱性磷酸酶动力学和构象的影响
Nasim Babaknejad,Behzad Shareghi,Ali Akbar Saboury
Nasim Babaknejad
This study observed the interaction between titanium dioxide (TiO2) nanoparticles and bovine intestinal alkaline phosphatase (BALP) through a combination of spectroscopic techniques and enzymatic activity assays. Fluorescence spectroscopy s...
Donor-specific, but not sex-specific, signatures dominate cell-type classification in lung scRNA-seq data [0.03%]
供者特异性的而非性别特异性的标志物主导了肺部单细胞RNA测序数据的细胞类型分类
Nora Ghenciulescu,Marcel J Reinders,Ahmed Mahfouz
Nora Ghenciulescu
Transcriptomic differences between individuals and sexes are well-documented across tissues, affecting cell-type identity. Single-cell atlases often have skewed sex ratios or limited donor diversity, potentially leading to sex- or donor-bia...
12(S)-HETE regulates the expression of IL-6 and IL-10 in cardiomyocytes through two distinct receptors, TXA2R and BLT2 [0.03%]
12(S)-HETE通过两种不同的受体TXA2R和BLT2调节心肌细胞中IL-6和IL-10的表达
Shota Mori,Yuma Takeda,Masashi Tomimatsu et al.
Shota Mori et al.
Cardiac inflammation contributes to the development and progression of heart failure (HF). Although cytokines are key mediators of cardiac inflammation, lipid-derived metabolites also play essential roles; however, their underlying mechanis...
10,11-Dehydrocurvularin attenuates LPS-induced neuroinflammation in BV2 cells by inhibiting the TLR2/MyD88/NLRP3 signaling pathway [0.03%]
大曲菌素通过抑制TLR2/MyD88/NLRP3信号通路减轻LPS诱导的神经炎症反应
Chenggang Tian,Jian Sun,Jinting Wang et al.
Chenggang Tian et al.
Neuroinflammation, driven by microglial activation and Toll-like receptor 2 (TLR2) signaling, is a hallmark of neurodegenerative diseases. While 10,11-Dehydrocurvularin (DCV) is known for its anti-inflammatory properties, its specific effec...
Structure-guided computational design of DNA tweezers for predicted recognition of the primary glioblastoma biomarkers S100A4 and midkine [0.03%]
基于结构的计算设计DNA夹具以预测识别胶质母细胞瘤主要生物标志物S100A4和中期素 PRIMARY GLIOBLASTOMA BIOMARKERS S100A4 AND MINK 的主链氨基酸序列作为模板，通过从头预测方法和同源模建方法相结合的方式，对结核分枝杆菌的PE_PGRS蛋白家族进行功能位点挖掘和作用机理研究。
Hayley Foo
Hayley Foo
Glioblastoma multiforme (GBM) is among the most aggressive malignant brain tumors and is characterized by severe infiltration into surrounding brain tissue, rendering early detection exceedingly difficult with current diagnostic imaging met...
Exploratory profiling of serum small extracellular vesicle-associated miRNAs as candidate biomarkers for Moyamoya disease [0.03%]
血清小细胞外囊泡相关miRNA的探索性谱分析作为 moyamoya 病候选生物标志物的研究
Lin Yan,Hao Ding,Ruifang Zhao et al.
Lin Yan et al.
Purpose: Moyamoya disease (MMD) is a chronic progressive cerebrovascular disease with elevated rates of mortality and disability in children and adults. Therefore, early and accurate identification of MMD is crucial for g...
Forensic validation and population genetic evaluation of an MPS-based integrated microhaplotype and Y-SNP/STR (MY) system [0.03%]
基于MPS的微等位基因和Y-SNP/STR(MY)体系的法医学验证及群体遗传学研究
Haoliang Fan,Qiqian Xie,Fenglong Yang et al.
Haoliang Fan et al.
Microhaplotypes (MHs) and Y-chromosomal single nucleotide polymorphisms (Y-SNPs) and short tandem repeats (Y-STRs) are highly informative genetic markers that complement the limitations of conventional autosomal forensic markers. We evaluat...
ARHGAP12 loss promotes tumor budding and lymphatic metastasis in gastric cancer [0.03%]
ARHGAP12缺失促进胃癌的肿瘤芽生和淋巴转移
Yong Ji,Xiaofeng Xu,Shihan Chen et al.
Yong Ji et al.
Background: Identifying the molecular drivers of metastasis and tumor budding (Tb) is essential for improving patient outcomes. This study aimed to characterize the expression pattern and functional contribution of ARHGAP...