Development of a physiologically-based pharmacokinetic model for cyclosporine in Asian children with renal impairment [0.03%]
亚洲儿童肾功能不全患者的环孢素生理药代动力学模型的建立
Sumin Yoon,Sojeong Yi,Su-Jin Rhee et al.
Sumin Yoon et al.
This study aimed to assess the pharmacokinetics of cyclosporine A (CsA) in Asian children with renal impairment (RI) by developing a physiologically-based pharmacokinetic (PBPK) model with Simcyp Simulator. The PBPK model of Asian children ...
Simultaneous quantification of ticagrelor and its active metabolite, AR-C124910XX, in human plasma by liquid chromatography-tandem mass spectrometry: Applications in steady-state pharmacokinetics in patients [0.03%]
高效液相色谱-串联质谱法同时定量人血浆中替卡格雷及其活性代谢产物AR-C124910XX的方法及其在患者稳态药代动力学中的应用
Soon Uk Chae,Kyoung Lok Min,Chae Bin Lee et al.
Soon Uk Chae et al.
A sensitive and simple liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous quantification of ticagrelor and its active metabolite, AR-C124910XX from 50 µL human plasma using tolbutamide as...
Cognition enhancing effect of panax ginseng in Korean volunteers with mild cognitive impairment: a randomized, double-blind, placebo-controlled clinical trial [0.03%]
人参对韩国轻度认知障碍志愿者的认知增强效果：随机、双盲、安慰剂对照临床试验
Key-Chung Park,Hui Jin,Renhua Zheng et al.
Key-Chung Park et al.
This study aimed to investigate the cognition-enhancing effect of Panax ginseng. A randomized, double-blind, placebo-controlled clinical trial was conducted to address the cognition-enhancing effects of Panax ginseng. A total of 90 Korean v...
Jin-Sol Park,Jung-Ryul Kim
Jin-Sol Park
MATLAB® is widely used for numerical analysis, modeling, and simulation. One of MATLAB's tools, SimBiology®, is often used for pharmacokinetic, pharmacodynamic model and dynamic systems; however, SimBiology seems to be rarely used for non...
Comparison of pharmacokinetic characteristics of two Tegoprazan (CJ-12420) formulations in healthy male subjects [0.03%]
两种替加环素(CJ-12420)制剂在健康受试者中的药代动力学特征比较研究
Jun Gi Hwang,Hyounggyoon Yoo,Ji Won Lee et al.
Jun Gi Hwang et al.
Proton-pump inhibitors (PPIs) are effectively used to treat acid-related diseases, including gastroesophageal reflux disease (GERD); however, many unmet medical needs still exist. As a new treatment option, potassium-competitive acid blocke...
Hyeseon Cho,Eun-Kyung Lee
Hyeseon Cho
Population pharmacokinetic analysis and modeling procedures typically require estimates of both population and individual pharmacokinetic parameters. However, only some of these parameters are contained in models and only parameters in the ...
Electrical storm induced by hypokalemia associated with herbal medicines containing licorice [0.03%]
低钾血症诱发的 herbs含甘草引起的尖端扭转型室速
Hyun Kuk Kim,Sung Soo Kim
Hyun Kuk Kim
A 60-year-old woman presented with polymorphic ventricular tachycardia secondary to hypokalemia, which necessitated dozens of DC cardioversions. She was not taking any other medication and denied any vomiting or diarrhea. Further investigat...
Antiepileptic drug-induced severe cutaneous adverse reactions and HLA alleles: A report of five cases with lymphocyte activation test [0.03%]
抗癫痫药所致严重皮肤不良反应与HLA等位基因的相关性检测及5例报告
Eun-Young Kim,Mi-Yeong Kim,Chan Sun Park et al.
Eun-Young Kim et al.
Antiepileptic drugs (AEDs) can induce severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. We perfor...
Kyungsoo Park
Kyungsoo Park
Although sciences and technology have progressed rapidly, de novo drug development has been a costly and time-consuming process over the past decades. In view of these circumstances, 'drug repurposing' (or 'drug repositioning') has appeared...