Transcriptomic response of brain tissue to focused ultrasound-mediated blood-brain barrier disruption depends strongly on anesthesia [0.03%]
基于麻醉的小脑组织的血脑屏障聚焦超声造影的转录组响应差异较大
Alexander S Mathew,Catherine M Gorick,E Andrew Thim et al.
Alexander S Mathew et al.
Focused ultrasound (FUS) mediated blood-brain barrier disruption (BBBD) targets the delivery of systemically-administered therapeutics to the central nervous system. Preclinical investigations of BBBD have been performed on different anesth...
Engineered macrophage membrane-enveloped nanomedicine for ameliorating myocardial infarction in a mouse model [0.03%]
工程化巨噬细胞膜包封纳米药物改善小鼠模型的心肌梗死
Yugang Xue,Guangwei Zeng,Jin Cheng et al.
Yugang Xue et al.
Myocardial infarction (MI) is the serious condition causing lots of death over the world. Myocytes apoptosis, inflammation, and fibrosis are three important factors implicated in pathogenesis of MI. Targeting these three factors has been sh...
Microscopy-guided laser ablation for the creation of complex skin models with folliculoid appendages [0.03%]
显微镜引导的激光消融技术创建带有毛发类似附属物的复杂皮肤模型的方法
Carla M Abreu,Luca Gasperini,Manuela E L Lago et al.
Carla M Abreu et al.
Engineering complex tissues requires the use of advanced biofabrication techniques that allow the replication of the tissue's 3D microenvironment, architecture and cellular interactions. In the case of skin, the most successful strategies t...
Justin Ko,Abhirup Mandal,Sunil Dhawan et al.
Justin Ko et al.
Choline geranate deep eutectic solvent/ionic liquid (CAGE) has shown several desirable therapeutic properties including antimicrobial activity and ability to deliver drugs transdermally in research laboratories. Here, we describe the first ...
Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles [0.03%]
核酸的细胞质递送：离子可变脂质纳米颗粒的例子
Michele Schlich,Roberto Palomba,Gabriella Costabile et al.
Michele Schlich et al.
Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano-delivery system for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with increased in vivo potency brought LNPs from the labor...
Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands [0.03%]
不含靶向配体的纳米颗粒体内递送mRNA至肝免疫细胞
Zubao Gan,Melissa P Lokugamage,Marine Z C Hatit et al.
Zubao Gan et al.
Once inside the cytoplasm of a cell, mRNA can be used to treat disease by upregulating the expression of any gene. Lipid nanoparticles (LNPs) can deliver mRNA to hepatocytes in humans, yet systemic non-hepatocyte delivery at clinical doses ...
Aaron C Anselmo
Aaron C Anselmo
IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) with digital drug development [0.03%]
IDentif.AI：使用数字药物开发快速优化严重急性呼吸系统综合症冠状病毒2（SARS-Cov-2）联合治疗方案设计
Agata Blasiak,Jhin Jieh Lim,Shirley Gek Kheng Seah et al.
Agata Blasiak et al.
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to multiple drug repurposing clinical trials that have yielded largely uncertain outcomes. To overcome this challenge, we used IDentif.AI, a platform that pai...
Effect of an alkyl spacer on the morphology and internalization of MUC1 aptamer-naphthalimide amphiphiles for targeting and imaging triple negative breast cancer cells [0.03%]
含MUC1适配体-萘甲亚胺两亲分子的纳米结构及其抗三阴性乳腺癌细胞能力的研究
Huihui Kuang,Zachary Schneiderman,Ahmed M Shabana et al.
Huihui Kuang et al.
Despite decades of research, there are few targeted treatment options available for triple negative breast cancer (TNBC), leaving chemotherapy, and radiation treatment regimes with poor response and high toxicity. Herein aptamer-amphiphiles...
Bicheng Li,Jie Gong,Siqi Sheng et al.
Bicheng Li et al.
Intraplaque hemorrhage (IPH) plays a major role in the aggressive progression of vulnerable plaque, leading to acute cardiovascular events. We previously demonstrated that sonodynamic therapy (SDT) inhibits atherosclerotic plaque progressio...