Exogenous matrix-free biomanufacturing of glioblastoma organoids enables autonomous assembly of neurovascular-like structures and extracellular matrix [0.03%]
外源性无矩阵生物制造胶质母细胞瘤类器官能够自主组装神经血管样结构和细胞外基质
Alexandra D Avera,Taylor N Schnorbus,Yonghyun Kim
Alexandra D Avera
Current glioblastoma (GBM) models often rely on chemically undefined exogenous extracellular matrices (ECMs) and serums that limit understanding of autonomous cellular behaviors driving tumor progression. Here, we present an exogenous ECM-f...
Rapamycin-nanoliposomes target the mTORC1-mediated autophagy-lysosomal and NLRP3/Caspase-1 pathways to inhibit nucleus pulposus cell senescence in intervertebral discs [0.03%]
雷帕霉素纳米脂质体靶向mTORC1介导的自噬溶酶体和NLRP3/caspase-1信号通路抑制椎间盘髓核细胞衰老
Hui Xing,Miao Yu,Jiabin Liu et al.
Hui Xing et al.
Nucleus pulposus (NP) cell quiescence maintains intervertebral disc homeostasis, while mTORC1 regulates autophagy-lysosomal function and inflammatory secretion to preserve quiescence-rapamycin specifically targets mTORC1. Herein, we fabrica...
Engineering autoimmune disease models using organoids: Harnessing microenvironmental engineering for precision medicine and immunological recapitulation [0.03%]
工程化自身免疫疾病类器官模型：利用微环境工程技术实现精准医疗与免疫系统再现
Chang-Jin Lee,Yeojin Kim,Misu Kim et al.
Chang-Jin Lee et al.
Autoimmune diseases-including systemic sclerosis (SSc), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA)-are increasingly understood as programmable microenvironmental states, wherein evolving changes in matrix mechanics, b...
Efficacy of decellularized meniscus xenogeneic substitutes from sheep and camels compared to human menisci [0.03%]
山羊和骆驼脱细胞半月板异种移植与人类半月板的效果比较
Mohammad Reza Khakzad,Saeed Vafaei-Nezhad,Tahereh Talaei-Khozani et al.
Mohammad Reza Khakzad et al.
Meniscal damage treatment is challenging due to limited healing potential. Decellularized scaffolds offer tissue engineering potential, but their efficacy depends on maintaining extracellular matrix structure, host integration, biocompatibi...
An ex vivo injury model perfused with whole blood reveals rapid mechanical and transcriptional changes within the spinal cord [0.03%]
全血灌注的体外损伤模型揭示了脊髓内的快速机械和转录变化
Laura De Marchi,Hoi Yan Yu,Gianna Riviello et al.
Laura De Marchi et al.
Secondary spinal cord injury (SCI), which includes a cascade of both biophysical and biochemical processes that mitigate neurological recovery, is thought to initiate within minutes of the direct, primary injury. However, previous in vitro ...
Harnessing nanotechnology: Transforming ocular drug delivery with advanced hydrogel systems [0.03%]
纳米技术在眼部药物递送中的应用：先进水凝胶系统的发展与转化医学
Huidi Cui,Hao Wu,Bizhu Zhao et al.
Huidi Cui et al.
Ocular drug delivery faces tremendous challenges in clinical practice. The eyeball possesses sophisticated anatomical and physiological characteristics that uniquely influence the pharmacokinetics of delivered drugs. This complexity necessi...
Open-source bioreactor delivers electrical and perfusion stimulation supporting 3D cardiac engineered tissue maturation [0.03%]
开放式生物反应器可提供电和灌注刺激支持三维心脏组织工程成熟化
Gregory Reid,Stefano Gabetti,Antonio Sileo et al.
Gregory Reid et al.
Cardiac tissue engineering requires control over physical stimuli, such as mechanical and electrical, to promote the maturation and functionality of cardiomyocytes. While perfusion bioreactors and electrical stimulation systems have been em...
Engineering human peritoneum in vitro: A novel microfluidic platform for modeling peritoneal physiology and pathophysiology [0.03%]
体外工程人类腹膜：一种用于模拟腹膜生理和病理生理的新型微流控平台
Katharina Peisert,Franziska Keßler,Sara Y Brucker et al.
Katharina Peisert et al.
The peritoneum, the body's largest serous membrane, plays critical roles in abdominal homeostasis and immune defense. When disrupted by surgery or disease, it can lead to devastating complications including peritoneal adhesions-affecting up...
Application of hydrogels in 3D tumor microenvironment modeling and drug screening for cervical cancer: A review [0.03%]
水凝胶在宫颈癌三维肿瘤微环境模型构建及药物筛选中的应用进展：综述文章
Ying Liu
Ying Liu
Cervical cancer, driven mainly by human papillomavirus (HPV) infection, remains one of the most common malignant tumors among women worldwide, posing significant challenges in treatment and drug development. Traditional two-dimensional (2D)...
Effects of multi-electrode electrostatic precipitation during intraperitoneal aerosolized drug delivery: Insights from a large animal model [0.03%]
多电极静电沉积在腹腔给药中的作用：大型动物模型的启示
Mohammad Rahimi-Gorji,Rosalie Ghesquière,Yiwen Long et al.
Mohammad Rahimi-Gorji et al.
Intraperitoneal aerosolized drug delivery (IPADD) has emerged as a promising local treatment approach for peritoneal metastasis (PM). However, its effectiveness is currently limited by uneven aerosol distribution and restricted tumor tissue...