Engineering ovarian tissue via biofabrication and 3D bioprinting: Challenges and emerging perspectives [0.03%]
基于生物制造和3D生物打印的卵巢组织工程：挑战与展望
Chieh En Hsu,Mario Mazza,Giordano Perini et al.
Chieh En Hsu et al.
The development of bioprosthetic ovaries using advanced biofabrication and 3D bioprinting technologies has achieved significant attention in recent years. This work begins with an analysis of ovarian anatomy and physiology, emphasizing the ...
Investigating the impact of hypoxia and syncytialization on lipid nanoparticle-mediated mRNA delivery to placental cells [0.03%]
探究缺氧和合胞体化对脂质纳米颗粒介导的信使RNA向胎盘细胞递送的影响
Rachel E Young,Tara Vijayakumar,Logan J Reilley et al.
Rachel E Young et al.
Placental dysfunction leads to pregnancy-related disorders that affect up to 15% of pregnancies. Several of these, such as preeclampsia, are symptomatically managed but have no curative treatments other than preterm delivery. Placental dysf...
Hangyu Zhou,Danni Zhou,Miaoben Wu et al.
Hangyu Zhou et al.
Over the past two decades, an increasing body of evidence has underscored the significant role of the mechanical properties of biological tissues in maintaining tissue functions and regulating cellular changes, such as proliferation, migrat...
Cell-embedded microgels as emerging miniature 3D tissue-mimics toward biochip-based toxicity screening [0.03%]
细胞嵌入微凝胶作为新兴的微型3D组织模拟物用于芯片上的毒性筛选
Margaux Delafosse,Estelle Regnault,Jasmin Gebauer-Barrett et al.
Margaux Delafosse et al.
Recent developments in synthetic three-dimensional (3D) gel microenvironments for cell culture have enabled the advancement of bioengineered organ-specific cell niches that resemble the native 3D tissue architecture and mechanics. In partic...
Stability of bacteriophages in spray-dried polymeric formulations: Effect of excipient polyvinylpyrrolidone glass transition temperature and molecular weight [0.03%]
喷雾干燥聚合成分配方中噬菌体的稳定性：增塑剂聚乙烯吡咯烷酮玻璃化温度和分子量的影响
Mengyu Li,Yue Cao,Hak-Kim Chan
Mengyu Li
Effective dry-state stabilization of bacteriophages is crucial for expanding their therapeutic use. This study builds on previous findings that saccharide-based formulations maintain phage stability when the glass transition temperature (Tg...
Samir Mitragotri
Samir Mitragotri
Overcoming challenges in cartilage regeneration: The role of chondrogenic inducers [0.03%]
软骨再生的挑战及促软骨诱导因子的作用
Manh Tuong Nguyen,Stan Gronthos,Yunpeng Zhao et al.
Manh Tuong Nguyen et al.
Cartilage regeneration presents unique challenges due to its avascular structure, sparse cell population, and limited regenerative capacity. Recent years have seen significant advancements in the field, which warrant an integrated review th...
Microfluidic approaches for liquid biopsy in glioblastoma: Insights into diagnostic and follow-up strategies [0.03%]
液相活检在胶质母细胞瘤中的微流体方法：诊断和随访策略的新见解
Clara Bayona,Teodora Ranđelović,Claudia Olaizola-Rodrigo et al.
Clara Bayona et al.
Glioblastoma (GBM) is a highly malignant brain tumor with a poor survival prognosis of 12-15 months despite current therapeutic strategies. Diagnosing GBM is challenging, often requiring invasive techniques such as tissue biopsy and imaging...
Improved efficacy and long-term protective effects of CXCR4/IL10 bioengineered mesenchymal stromal cells in a model of inflammatory bowel disease [0.03%]
CXCR4/IL10工程化间充质基质细胞在炎症性肠病模型中的疗效及长期保护作用改善
Mercedes Lopez-Santalla,Marta C Ordoñez-Velasco,Maria Fernandez-Garcia et al.
Mercedes Lopez-Santalla et al.
Mesenchymal stromal cell (MSCs)-based therapies have emerged as a promising approach for inflammatory bowel disease (IBD) treatment due to their immunosuppressive and regenerative properties. However, clinical trials have shown limited ther...
Molecular switch-mediated detection of EGFR deletion mutations and its application to cfDNA analysis [0.03%]
基于分子开关的EGFR删除突变检测及其在液态活检中的应用
Ying-Ying Xu,Lu-Yan Wang,Sheng-Mei Zhou et al.
Ying-Ying Xu et al.
Sensitive and effective detection of epidermal growth factor receptor (EGFR) mutations is crucial for the early screening and diagnosis of non-small cell lung cancer (NSCLC). In this study, we assessed the sensitivity and specificity of the...