Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands
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Once inside the cytoplasm of a cell, mRNA can be used to treat disease by upregulating the expression of any gene. Lipid nanoparticles (LNPs) can deliver mRNA to hepatocytes in humans, yet systemic non-hepatocyte delivery at clinical doses remains difficult. W... ...
