High-Precision Performance of a Full-Ocean-Depth pH Sensor: Calibration and Assessment under Simulated Hadal Pressure Conditions [0.03%]
全 ocean 深度 pH 传感器的高精度性能：在模拟海沟压力条件下的校准与评估
Huixiu Mao,Yunwen Shen,Yuankai Lu et al.
Huixiu Mao et al.
Real-time in situ pH monitoring in the hadal zone is essential for resolving deep-sea carbon dynamics but is severely challenged by extreme hydrostatic pressures and complex biochemical environments. Current sensors often lack the necessary...
Hydrogel Microbead-Confined Nanozyme-SERS Sensor for Robust Detection of Hydrogen Peroxide in Complex Biological Systems [0.03%]
用于复杂生物系统中过氧化氢 robust 检测的水凝胶微球限制型纳米酶 SERS 传感器
Xin Wang,Yang Yang,Lili Cong et al.
Xin Wang et al.
Inflammation-associated oxidative stress is critically involved in the initiation and progression of numerous pathological processes, yet its reliable detection in complex biological environments remains a major analytical challenge. Herein...
Cell-Based Multisensor Array for Vapor-Phase Detection of Cancer-Related Compounds in Human Urine [0.03%]
基于细胞的多传感器阵列用于检测人尿中与癌症相关的化合物
Hisatoshi Mimura,Toshihisa Osaki,Haruka Oda et al.
Hisatoshi Mimura et al.
Detecting volatile biomarker candidates in complex biological samples is a key challenge in sensor science, particularly for noninvasive disease screening applications. Biohybrid sensors based on olfactory receptor-expressing cells offer hi...
Mechanism-Informed Design Framework of Nanocrystalline Semiconductor Chemiresistors Enabling Room-Temperature, ppb-Level, Dual-Redox Gas Sensing [0.03%]
基于机制的纳米晶半导体化学电阻器设计框架实现室温下ppb级双氧化还原气体传感
Yanyan Li,Liang Wu,Zhuoyang He et al.
Yanyan Li et al.
Wearable breath and environmental monitoring require room‑temperature gas sensors that detect oxidizing pollutants and reducing biomarkers at trace levels. Most nanocrystalline chemiresistive sensors are still optimized by an isolated stra...
Modular CRISPR-Cas12a-Activated Gold Nanoparticle Assay for Rapid Visual Detection of Hepatocellular Carcinoma-Related miRNAs [0.03%]
一种用于快速视觉检测肝细胞癌相关miRNA的模块化CRISPR-Cas12a激活金纳米颗粒测定法
Yinghui Sun,Rui Wang,Hongxiao Sun et al.
Yinghui Sun et al.
MicroRNAs (miRNAs) are emerging biomarkers for early hepatocellular carcinoma (HCC) detection, but most CRISPR-Cas12a assays rely on reverse transcription and preamplification and often lack simple visual readouts. Here, we develop a revers...
Oxygen Vacancy Engineering and Synergistic Electrocatalysis of NiFe-LDH for Boosting Coordination Aggregation-Induced Electrochemiluminescence of Zr-MOF to Detect Heart-Type Fatty Acid Binding Protein [0.03%]
氧空位工程和NiFe-LDH的协同电催化解集 coordination aggregation-诱导Zr-MOF电化学发光检测心型脂肪结合蛋白
Shenglan Hu,Zhi Luo,Xiangfei Zheng et al.
Shenglan Hu et al.
The development of high-performance electrochemiluminescence (ECL) biosensors is often hindered by the intrinsically weak and unstable ECL emission of organic luminophores. To address this challenge, we propose a novel strategy that integra...
Water-Soluble Viscosity-Activated Molecular Rotor for In Situ Imaging of Liver Damage in the NIR-II Window [0.03%]
一种用于近红外二区窗口成像的水溶性黏度激活型分子旋转探针用于肝脏损伤原位成像
Yufei Qin,Jiaming Guo,Huiyan Zhang et al.
Yufei Qin et al.
Microviscosity in the hepatic microenvironment changes during steatosis, matrix remodeling, and drug-induced injury but remains challenging to monitor in vivo. Here, we report JMR-1002-PEG, a water-soluble near-infrared II (NIR-II, 1000-170...
An Enzyme-Responsive Gd(III) MRI Probe for Visualizing β-Hexosaminidase A Activity [0.03%]
一种用于可视化β-己糖胺酶A活性的Gd(III)核磁共振造影剂响应式酶分子探针
Minrui Luo,Jian-Hong Tang,Yiqing Lei et al.
Minrui Luo et al.
We report the design, synthesis, and evaluation of HexA-Gd, a bioresponsive magnetic resonance imaging (MRI) contrast agent for the selective detection of β-hexosaminidase A (Hex-A) activity. The probe employs a self-immolative linker stra...
Machine Learning-Enabled Gas Sensor Based on MOF-Derived In2O3-CuO for Exhaled CO Detection [0.03%]
基于MOF衍生的In2O3-CuO的机器学习呼吸CO检测气体传感器
Fan Zhao,Zhiyuan Jiang,Xiangrui Jiang et al.
Fan Zhao et al.
Noninvasive, precise breath analysis holds significant importance for the screening and monitoring of neonatal jaundice, with its core challenge lying in the specific detection of the key biomarker carbon monoxide (CO) within complex breath...
In Situ Grown ZnIn2S4@ZnWO4 Heterojunction for Highly Sensitive Photoelectrochemical Detection of Chlorogenic Acid [0.03%]
原位生长的ZnIn2S4@ZnWO4异质结高效检测绿原酸传感器
Xiaoqian Sun,Qian Zheng,Linzi Huang et al.
Xiaoqian Sun et al.
Chlorogenic acid (CA) is a phenolic acid compound with broad biological activity. In this study, a high-performance photoelectrochemical sensor based on in situ grown ZnIn2S4@ZnWO4 heterojunctions was developed for the sensitive detection o...