Developing PhoR-PhoB-Based Biosensor by Directed Evolution for Application in Ultralow Inorganic Phosphorus Detection [0.03%]
基于定向进化开发的PhoR-PhoB体系超低无机磷检测型生物传感器
Wenyan Cao,Xuan Zhou,Chao Huang et al.
Wenyan Cao et al.
Inorganic phosphorus (Pi) is vital for all living organisms, but abnormal Pi levels in water and serum pose significant eutrophication and health risks. This study developed a highly sensitive PhoR-PhoB-based biosensor for ultralow-level Pi...
Direct Intramolecular Chemiexcitation Strategy Enables Sensitive Chemiluminescence Imaging of HOCl in Rheumatoid Arthritis [0.03%]
直接分子内化学激发策略实现对风湿关节炎中HOCl的高灵敏化学位移成像检测
Chen Han,Zhihui Jia,Tengfei Zhang et al.
Chen Han et al.
As a pivotal pathophysiological biomarker, hypochlorous acid (HOCl) necessitates sensitive detection technologies to resolve its spatiotemporal dynamics in biological systems. Excitation-free chemiluminescent probes circumvent tissue autofl...
Activity-Based Nanoprobes for Multiscale Functional Analysis of Proteases in Medulloblastomas [0.03%]
基于活性的纳米探针在髓母细胞瘤中多尺度功能性分析蛋白酶的研究
Ying Yu,Yuning Wang,Yijia Peng et al.
Ying Yu et al.
Enzymes mediate diverse cancer processes by exerting their functional activities. Precise profiling of enzyme activity in the tumor microenvironment (TME) is therefore critical to understanding and targeting the pathological roles of enzyme...
Haoming Sun,Congling Yin,J Paul Attfield et al.
Haoming Sun et al.
Resistive sensors are widely used to detect gases, but integrating magnetoresistive effects for enhanced selectivity and sensitivity remains largely unexplored. Here we have investigated several magnetic materials in a metal oxide semicondu...
Metal-π Interaction-Enhanced Electrochemiluminescence via U-Shaped Schiff Base Luminophores for Ultrasensitive Clindamycin Detection [0.03%]
通过U形席夫碱发光体增强金属-π相互作用的电致化学发光用于超灵敏克林霉素检测
Li-Ping Zong,Xi-Jie Li,Dunru Zhu et al.
Li-Ping Zong et al.
The advancement of electrochemiluminescence (ECL) sensing has been increasingly restricted by the lack of rationally designed luminophores that simultaneously support efficient charge transfer, excited-state stability, and catalytic amplifi...
Hierarchical WO3 Nanofibers for Ultrasensitive Gas Detection via Pore-Creating and Inner Anchoring Silver Nanoparticles [0.03%]
通过孔隙创建和内部固定银纳米颗粒的WO3纳米纤维 hierarchical WO3纳米纤维在超灵敏气体传感中的应用
Chuanxuan Zhou,Shaowei Li,Fuchao Yang et al.
Chuanxuan Zhou et al.
Ultrasensitive detection of triethylamine (TEA), a characteristic volatile in seafood, is particularly important for food safety and human health. The preparation of nanosensing materials with special structures is an important step toward ...
Engineering a Viscosity-Gated Dual-Rotor Probe for Comprehensive Mapping of Lipid Droplet Heterogeneity [0.03%]
工程设计粘度门控双转子探针以全面映射脂滴异质性
Tantan Yang,Zhuofeng Li,Ting Liang et al.
Tantan Yang et al.
Small, metabolically active lipid droplets (LDs) with elevated core viscosity play pivotal roles in lipid metabolism and disease yet remain underexplored due to their transient nature and the limitations of conventional probes. Here, we rep...
Pocket Electronic Nose Integrating an Ultra-Compact Sensor Array Chip and Spatiotemporal Network Enables Highly Selective Gas Sensing [0.03%]
集成超紧凑型传感器阵列芯片和时空网络的便携式电子鼻实现 highly selective 气体传感
Xingguo Wang,Xing Kang,Xinyi Chen et al.
Xingguo Wang et al.
Accurately distinguishing gases with nearly identical molecular structures─such as nitric oxide (NO) and nitrogen dioxide (NO2)─remains challenging for conventional sensors. We report a palm-sized (5 cm × 5 cm) electronic nose that integ...
An Interpretable Sensor Selection Strategy for Array Optimization and Performance Enhancement [0.03%]
一种可解释的传感器选择策略，用于阵列优化和性能增强
Haixia Mei,Jingyi Peng,Tao Wang et al.
Haixia Mei et al.
As more sensors are integrated into electronic nose (E-nose) systems to enhance gas detection accuracy, multitasking capabilities, and expand application scenarios, several challenges arise. These challenges include issues such as cross-sen...
Digital Profiling Subpopulations of Cancer Cell-Derived Exosomes via Aptamer-SERS Nanotags on a Wafer-Level Micropillar Array Chip [0.03%]
基于瓦片级微柱阵列芯片的SERS纳米标签捕获鉴定循环肿瘤细胞外泌体子群体的新方法
Chunyan Zhu,Xiaodong Lin,Ruyun Jin et al.
Chunyan Zhu et al.
The clinical translation of exosome-based diagnostics and therapies is hindered by significant molecular heterogeneity. Current exosome phenotyping methods suffer from insufficient sensitivity, limited multiplexing capability, and poor scal...