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Multilayer Plasmon Hybridization in Au-Ag-Au Nanoparticles Enables Extinction Amplification in Transport-Limited One-Step Confirmatory Syphilis Biosensing

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Syphilis diagnosis requires pairing treponemal and non-treponemal antibody results, yet rapid tests combining both markers lose sensitivity at the low RPR titers (≤1:4) most critical in early infection and pregnancy. The limitation lies with the reporter: con... ...