Qiao Yi Chen,Max Costa,Hong Sun
Qiao Yi Chen
MOF was first identified in Drosophila melanogaster as an important component of the dosage compensation complex. As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16. ...
Biophysical characterization and modeling of human Ecdysoneless (ECD) protein supports a scaffolding function [0.03%]
生物物理表征和模拟的人Ecdysoneless（ECD）蛋白支持了一个支架功能
Riyaz A Mir,Jeff Lovelace,Nicholas P Schafer et al.
Riyaz A Mir et al.
The human homolog of Drosophila ecdysoneless protein (ECD) is a p53 binding protein that stabilizes and enhances p53 functions. Homozygous deletion of mouse Ecd is early embryonic lethal and Ecd deletion delays G1-S cell cycle progression. ...
Topological diversity of chromatin fibers: Interplay between nucleosome repeat length, DNA linking number and the level of transcription [0.03%]
染色质纤维的拓扑多样性：核小体重复长度、DNA联结数和转录水平之间的相互作用
Davood Norouzi,Ataur Katebi,Feng Cui et al.
Davood Norouzi et al.
The spatial organization of nucleosomes in 30-nm fibers remains unknown in detail. To tackle this problem, we analyzed all stereochemically possible configurations of two-start chromatin fibers with DNA linkers L = 10-70 bp (nucleosome repe...
New open conformation of SMYD3 implicates conformational selection and allostery [0.03%]
SMYD3的新开放构象表明了构象选择和别构效应
Nicholas Spellmon,Xiaonan Sun,Wen Xue et al.
Nicholas Spellmon et al.
SMYD3 plays a key role in cancer cell viability, adhesion, migration and invasion. SMYD3 promotes formation of inducible regulatory T cells and is involved in reducing autoimmunity. However, the nearly "closed" substrate-binding site and po...
Maysaa Doughan,Nicholas Spellmon,Chunying Li et al.
Maysaa Doughan et al.
STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain [0.03%]
STIM1的激活由靠近CRAC活化域的14个氨基酸序列调节
Marek K Korzeniowski,Barbara Baird,David Holowka
Marek K Korzeniowski
Oligomerization of the Ca2+ sensor, STIM1, in the endoplasmic reticulum (ER) membrane, caused by depletion of ER Ca2+ stores, results in STIM1 coupling to the plasma membrane Ca2+ channel protein, Orai1, to activate Ca2+ influx in a process...
Michael J Hamilton,Matthew D Young,Silvia Sauer et al.
Michael J Hamilton et al.
Long non-coding RNAs (lncRNAs) are a class of RNA molecules that are changing how researchers view eukaryotic gene regulation. Once considered to be non-functional products of low-level aberrant transcription from non-coding regions of the ...
Wei Zhang,Sheng Cao,Jessica L Martin et al.
Wei Zhang et al.
Retrovirus morphogenesis entails assembly of Gag proteins and the viral genome on the host plasma membrane, acquisition of the viral membrane and envelope proteins through budding, and formation of the core through the maturation process. A...
J Bernard Heymann
J Bernard Heymann
Validation is a necessity to trust the structures solved by electron microscopy by single particle techniques. The impressive achievements in single particle reconstruction fuel its expansion beyond a small community of image processing exp...