Wireless, skin-interfaced multimodal sensing system for continuous psychophysiological monitoring-A wearable polygraph device [0.03%]
一种用于连续心理生理监测的无线皮肤感应多模式传感系统-一款便携式测谎装置
Sun Hong Kim,Tae Wan Park,Seunghee Cho et al.
Sun Hong Kim et al.
Accurate, continuous monitoring of psychophysiological states is central to understanding stress and autonomic dysfunction across diverse medical contexts. Current approaches such as polygraphy and polysomnography rely on cumbersome, wired ...
A thyroid hormone-mediated opsin switch initiates metamorphosis in a proto-vertebrate [0.03%]
一种甲状腺激素介导的视蛋白转换启动了原脊椎动物的变态发育
Andrea Mariossi,Michael S Levine
Andrea Mariossi
Thyroid hormones (THs) initiate metamorphosis in vertebrates, although the evolutionary origins of this process are uncertain. Here, we show that most TH processing genes are present in the proto-vertebrate model Ciona and play an instructi...
From hotspots to hotspaces: Cascaded photonic-plasmonic coupling for SERS-based deep profiling of whole small extracellular vesicles [0.03%]
从热点到热空间：用于SERS基外泌体深剖的级联等离激元-光子耦合技术
Haoming Bao,Emily Xi Tan,Jie Zhou et al.
Haoming Bao et al.
The spatial confinement of electromagnetic hotspots ( 106, a regime inaccessible to conventional surface-enhanced Raman scattering (SERS) platforms. In silico simulations and experiments reveal ~20-fold enhancements in signal intensity and ...
Axial-time mapping: A diagnostic method to reveal concealed long-term catalyst deactivation mechanism in CO2 hydrogenation [0.03%]
轴向时间图谱法：一种揭示二氧化碳氢化反应中隐蔽长期催化剂失活机制的诊断方法
Wonjoong Yoon,Sheraz Ahmed,Heuntae Jo et al.
Wonjoong Yoon et al.
An axial-time mapping (ATM) with dual time axes-catalyst-reactant contact time (tc) and time on stream (TOS)-is developed to clarify long-term deactivation mechanisms of iron catalysts in CO2 hydrogenation. Treating tc and TOS as spatially ...
4D printing of hierarchically porous carbon-supported high-entropy ceramic metamaterial for tunable microwave absorption [0.03%]
用于可调谐微波吸收的分级多孔碳支撑高熵陶瓷超材料的4d打印技术
Guanghui Feng,Shuo Wang,Amr Osman et al.
Guanghui Feng et al.
Broadband-tunable electromagnetic wave absorption materials are critical for dynamic scenarios, such as those in wireless communication and radar systems. However, conventional absorbers are limited by narrow bandwidth and fixed postfabrica...
Glycerol-mediated nose-to-brain codelivery of anti-IL-17 and anti-CD73 antibodies enhances immunotherapy for melanoma brain metastases [0.03%]
甘油介导的抗IL-17和抗CD73抗体鼻脑共递送技术可增强黑色素瘤脑转移免疫治疗效果
Xuhong Yang,Hui Yang,Nuo Xu et al.
Xuhong Yang et al.
Immune checkpoint inhibitors show promise in the treatment of melanoma brain metastases but are limited by CD73/adenosine axis-mediated immune evasion. Directly targeting CD73 with antibodies faces challenges due to poor blood-brain barrier...
Synergistic antioxidant and gene supplementation for high-efficacy retinitis pigmentosa therapy [0.03%]
高效治疗视网膜色素变性疾病的协同抗氧化和基因补充法
Fuhua Wu,Haiping Wu,Jialiang Yang et al.
Fuhua Wu et al.
Retinitis pigmentosa (RP) is a leading cause of inherited blindness, yet current gene supplementation strategies are limited by heterogeneous responses, with more than 40% of patients showing insufficient rescue. Moreover, oxidative stress ...
Fate of isoprene peroxy radical constrains the urban photochemical regime [0.03%]
异丙烯过氧基命运决定了城市光化学反应体系状态
Michael A Robinson,Matthew M Coggon,Kelvin H Bates et al.
Michael A Robinson et al.
Declining nitrogen oxide (NOx = NO + NO2) emissions have transformed oxidation pathways in urban atmospheres, with implications for air quality. Organic peroxy radicals (RO2), key intermediates in volatile organic compound oxidation, typica...
Shiji Zhao,Jiajun Huang,Chaoqun Li et al.
Shiji Zhao et al.
Self-organized criticality (SOC) provides a universal framework for understanding the emergence of scale-invariant behaviors in complex systems, yet its physical realization in programmable artificial systems remains challenging. We present...
m6A RNA modification guides alternative polyadenylation to maintain T cell quiescence [0.03%]
m6A RNA修饰指导替代polyadenylation以维持T细胞静息状态
Xingli Zhang,Haixin Li,Gaoyang Wang et al.
Xingli Zhang et al.
N6-Methyladenosine (m6A) is primarily enriched in the last exons and 3' untranslated regions (3'UTRs) of messenger RNAs (mRNAs) and is associated with T cell homeostasis. Upon T cell activation, global mRNA 3'UTR shortening is facilitated t...