Structure and dynamics of a multidomain nitric oxide synthase regulated by a C2 domain [0.03%]
C2结构域调节的多结构域一氧化氮合酶的结构和动力学研究
Dhruva Nair,Brian R Crane
Dhruva Nair
Nitric oxide synthase (NOS) is a widely studied multidomain redox enzyme that produces the key signaling molecule and cytotoxic agent nitric oxide (NO) for functions that range from mammalian vasodilation to prokaryotic antibiotic resistanc...
Electrochemical conversion of oxalic acid to glycolic acid via oxygen vacancy-mediated tandem catalysis [0.03%]
基于氧空位串联催化的草酸电化学转化制备甘醇酸
Min Li,Fantao Kong,Hao Zhuo et al.
Min Li et al.
The electrochemical conversion of oxalic acid (OX) to glycolic acid (GC) offers a sustainable route for biomass valorization yet suffers from inefficient proton-coupled electron transfer and competitive hydrogen evolution. We report an oxyg...
Structures of the 26 S proteasome in complex with the Hsp70 co-chaperone Bag1 reveal a mechanism for direct substrate transfer [0.03%]
与Hsp70辅分子伴侣Bag1复合的26S蛋白酶体结构揭示直接底物转移机制
Moisés Maestro-López,Tat Cheung Cheng,Jimena Muntaner et al.
Moisés Maestro-López et al.
Coupling between the chaperone and degradation systems, particularly under stress, is essential for eliminating unfolded proteins. The co-chaperone Bag1 links Hsp70 to the 26S proteasome, recruiting Hsp70-bound clients for proteasomal degra...
Changhao Jia,Xiaoke Yang,Ming-Hui Zhao et al.
Changhao Jia et al.
The complement system plays a fundamental role in immunity, and its dysregulation is implicated in numerous human diseases. Activation of complement occurs through three main pathways: classical, lectin, and alternative; which converge at t...
RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity [0.03%]
RAD51C-XRCC3复合体调控FANCM介导的RNA-DNA杂交链解析以维护基因组稳定性
Satyaranjan Sahoo,Tarun Nagraj,Debanjali Bhattacharya et al.
Satyaranjan Sahoo et al.
Fanconi anemia (FA) is characterized by bone marrow failure, congenital abnormalities, and cancer predisposition. Mutations in RAD51 paralogs have been identified in FA-like disorders and cancers. Although the role of RAD51 paralogs is well...
Evidence that extra copies of chromosome 1q play a role in the early phases of pancreatic neoplasia [0.03%]
染色体1q的多余拷贝参与胰腺肿瘤早期发展阶段的确切证据
Christopher Douville,Jeeun Parksong,Marco Dal Molin et al.
Christopher Douville et al.
We searched for oncogenes activated by copy number increases using whole-genome sequencing data of 535 pancreatic ductal adenocarcinomas (PDACs). We found that gains of 1q were the second most common gain, occurring in 213 (39.8%) of PDACs....
Repurposing Si CMOS nonidealities for stochastic and analog image processing [0.03%]
基于Si CMOS非理想的类脑计算研究
Been Kwak,Ryun-Han Koo,Changhyeon Han et al.
Been Kwak et al.
Conventional semiconductor device engineering regards intrinsic device nonidealities as reliability concerns to be minimized or eliminated. Here, we demonstrate the strategic repurposing of these nonidealities as functional resources for ad...
Engineering controlled-release steroid therapeutics: fabrication and molecular design of self-assembled microparticles [0.03%]
工程控制激素缓释治疗手段：自组装微粒的制备及分子设计
Oluwaseun D Akanbi,Michael L Felder,Daniel Kupor et al.
Oluwaseun D Akanbi et al.
Steroids, specifically bile salts and corticosteroids, treat bile synthesis disorders, liver dysfunction, and inflammation. However, these water-soluble steroid drugs are rapidly cleared from the desired sites of action in the body, necessi...
Precise modulation of MOF pore structures via functional group dimensions and spatial configuration for membrane separation [0.03%]
通过功能基团尺寸和空间构型精确调节MOF孔结构用于膜分离
Weijian Sun,Kaicheng Yang,Yifan Zhao et al.
Weijian Sun et al.
Traditional petroleum distillation faces high energy demands, necessitating innovative alternatives like membrane separation. This study presents a breakthrough in dual-range and precise pore size modulation of metal-organic frameworks (MOF...
Single-cell epigenetic profiling reveals a tumor-intrinsic interferon response program in ccRCC tied to poor prognosis and BAP1 loss [0.03%]
单细胞表观基因组分析揭示了ccRCC中的肿瘤内在干扰素反应程序与预后不良和BAP1丢失相关性
Sabrina Y Camp,Meng Xiao He,Michael S Cuoco et al.
Sabrina Y Camp et al.
Transcriptional programs in renal cell carcinoma (RCC) have been linked to tumor heterogeneity and clinical outcomes, but analogous efforts to define chromatin programs shaping disease biology have been limited. Here, we generated single-ce...