Single coadministration of erythrocyte-uricase conjugate and immunosuppressant induces durable immune tolerance for gout therapy [0.03%]
单剂量红细胞-尿酸酶共轭物和免疫抑制剂联合给药可诱导痛风治疗的持久免疫耐受
Xiaoqian Nie,Yuehua Liu,Xingyun Yao et al.
Xiaoqian Nie et al.
Uricase (UOX) is effective for treating refractory gout but is limited by antidrug antibody (ADA) formation, which leads to loss of efficacy and infusion reactions. Here, we demonstrate that a single coadministration of erythrocyte-conjugat...
Balancing selection of climate adaptive loci underlies the success of introduction of Eurasian Tree Sparrows [0.03%]
适应气候位点平衡选择下欧亚树燕引种成功之谜
Yilin Chen,Shuai Zhang,Wenqing Zang et al.
Yilin Chen et al.
Human-mediated introductions have enabled species to colonize beyond their native ranges, yet the mechanisms underlying successful establishment remain unclear. We combined genomic and ecological analyses to investigate parallel introductio...
Toward human-resolution haptics: A high-bandwidth, high-density, wearable tactile display [0.03%]
面向人类触觉分辨率的高带宽、高密度可穿戴触觉显示器
Sylvia Tan,Michael A Peskhin,Roberta L Klatzky et al.
Sylvia Tan et al.
Despite advances in digitizing vision and hearing, touch still lacks an equivalent digital interface matching the fidelity of human perception. This gap limits the quality of digital tactile information and the realism of virtual experience...
Forecast attribution reveals enhanced heat mortality from climate change in British Columbia heatwave [0.03%]
预测归因表明，在不列颠哥伦比亚省热浪中，气候变化加剧了热死亡事件
Chin Yang Shapland,Y T Eunice Lo,Nicholas J Leach et al.
Chin Yang Shapland et al.
In 2021, Canada experienced one of the most extreme heatwaves ever seen anywhere on the globe. We use a weather forecast model to attribute health impacts to climate change. We simulate the heatwave as a present-day forecast, a preindustria...
Daniel Weller,Thomas Matreux,Iris B A Smokers et al.
Daniel Weller et al.
Phosphorus is essential for extant and nascent life. However, phosphate's low terrestrial abundance and the poor aqueous solubility of phosphorus-bearing minerals pose major hurdles for prebiotic chemistry. Here, we show that silicate-phosp...
Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation [0.03%]
通过STING烷基化编程闭环逆转肝纤维化的无载体纳米系统矩阵机械重塑载物
Hongyun Han,Dongrun Yu,Yuxiang Liu et al.
Hongyun Han et al.
Extracellular matrix (ECM) sclerosis represents a prominent feature of fibrotic disorders; however, the macrophage response to changes in matrix stiffness and its impact on fibrotic diseases remain unclear. This study reveals a vicious circ...
Carbon catalysts for CO2 conversion: From carbon emissions to zero-carbon solutions [0.03%]
用于CO2转化的碳基催化剂：从碳排放到零排放解决方案
Zhenhai Xia,Huanyu Jin,Yao Zheng et al.
Zhenhai Xia et al.
For millions of years, Earth's carbon cycle remained stable, but anthropogenic emissions drive severe air pollution and climate change. Addressing this crisis necessitates innovative decarbonization strategies, where carbon catalysts emerge...
Heterogeneous integration of ultrawide bandgap semiconductors for radio frequency power devices [0.03%]
用于射频功率器件的超宽带隙半导体异质集成
Hong Zhou,Min Zhou,Mingjie Xiang et al.
Hong Zhou et al.
Ultrawide bandgap (UWBG) semiconductors offer high critical electric fields and saturation velocities ideal for radio frequency (rf) devices, but achieving both shallow-level doping and high thermal conductivity (kT) in a single material re...
Nora Gera,Emma Pierson
Nora Gera
Tests for racial bias commonly assess whether two people of different races are treated differently. A fundamental challenge is that, because two people may differ in many ways, factors besides race might explain differences in treatment. H...
3D necroprinting: Leveraging biotic material as the nozzle for 3D printing [0.03%]
三维死亡打印：利用生物材料作为3D打印喷嘴
Justin Puma,Zhen Yang,Evan Johnston et al.
Justin Puma et al.
Nature has long inspired engineering innovations. Recent advances in biohybrid research have taken this inspiration further by directly integrating biotic materials into engineered systems. Here we report "3D necroprinting," a biohybrid man...