Computer vision-guided rapid and precise automated cranial microsurgeries in mice [0.03%]
计算机视觉引导的快速精确的小鼠颅内微操作手术系统
Zahra S Navabi,Ryan Peters,Beatrice Gulner et al.
Zahra S Navabi et al.
A common procedure that allows interfacing with the brain is cranial microsurgery, wherein small to large craniotomies are performed on the overlying skull for insertion of neural interfaces or implantation of optically clear windows for lo...
Hsin-Hung Li,Thomas C Sprague,Aspen H Yoo et al.
Hsin-Hung Li et al.
To mitigate capacity limits of working memory, people allocate resources according to an item's relevance. However, the neural mechanisms supporting such a critical operation remain unknown. Here, we developed computational neuroimaging met...
Intratumoral mycobiome heterogeneity influences the tumor microenvironment and immunotherapy outcomes in renal cell carcinoma [0.03%]
肾细胞癌瘤内真菌群落的异质性影响肿瘤微环境和免疫治疗的效果
Weiming Mou,Zhixing Deng,Lingxuan Zhu et al.
Weiming Mou et al.
The intratumoral mycobiome plays a crucial role in the tumor microenvironment, but its impact on renal cell carcinoma (RCC) remains unclear. We collected and quantitatively profiled the intratumoral mycobiome data from 1044 patients with RC...
Revealing the charge transport physics in metallic coordination nanosheets by thermoelectric and magnetotransport measurements [0.03%]
通过热电和磁阻测量揭示金属配合物纳米片中的载流子传输性质
Tian Wu,Xinglong Ren,David Cornil et al.
Tian Wu et al.
We have studied the charge transport physics of high-quality conducting coordination nanosheets films based on the benchmark material copper benzenehexathiol (CuBHT) by measuring multiple thermoelectric and magnetotransport coefficients on ...
Armored polymer-fluid gels with integrated damping and impact protection across broad temperatures [0.03%]
可在宽温度范围内集成阻尼和冲击防护的装甲聚合物-流体凝胶
Guoqing Chen,Jiabin Wu,Zhenwu Wang et al.
Guoqing Chen et al.
Unpreferable vibrations and impacts pose substantial risks to sensitive devices, structures, and the human body, demanding materials capable of providing both high energy dissipation and impact protection across a broad temperature range. T...
Synthesis of Campylobacter jejuni capsular oligosaccharides and identification of a potential O-antigen against campylobacteriosis [0.03%]
幽门螺杆菌荚膜低聚糖的合成及潜在O抗原的鉴定用于对抗Campylobacter感染
Jianjun Wang,Xuemei Yang,Zirong Huang et al.
Jianjun Wang et al.
The vaccines against campylobacteriosis are urgently needed because of the rising multidrug resistance of pathogenic Campylobacter jejuni. The capsular polysaccharides of these bacteria, containing unique 6-deoxy-β-d-ido-heptopyranosyl or ...
Effective recognition of double-stranded RNA does not require activation of cellular inflammation [0.03%]
有效的双链RNA识别不需要激活细胞炎症反应路径
Karolina Drazkowska,Julia Cieslicka,Michal Kitowicz et al.
Karolina Drazkowska et al.
Excess double-stranded RNA (dsRNA) is present in the cytoplasm of human cells, usually following viral infections. Recognition of dsRNAs activates innate immune pathways, leading to cellular inflammation and inhibition of cell growth. Here,...
Huachun Deng,Xiong Jiang,Yao Zhang et al.
Huachun Deng et al.
Chiral quasi-bound states in the continuum are spin-dependent high-Q resonances in meta-photonic structures that are realized by perturbing symmetry-protected optical states by engineering in-plane and out-of-plane asymmetries, and they sup...
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution [0.03%]
ARMC1在不同的复合物之间分配并与MIRO结合MTFR以控制线粒体分布
Michael J McKenna,Felix Kraus,João P L Coelho et al.
Michael J McKenna et al.
Maintaining an optimal mitochondrial distribution is critical to ensure an adequate supply of energy and metabolites to support important cellular functions. How cells balance dynamic mitochondrial processes to achieve homeostasis is incomp...
Penghui Li,Jun Li,Qilong Feng et al.
Penghui Li et al.
Ductility is critical for preventing materials catastrophic fracture. However, achieving tensile ductility in covalent materials remains challenging and unexplored because of the strong, directional covalent bonds. Here, we unveiled the rem...