Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita [0.03%]
小鼠Ten1丢失诱导染色体端粒缩短并模拟人类先天性毛细血管扩张性共济失调症
Adrián Sanz-Moreno,Lore Becker,Kan Xie et al.
Adrián Sanz-Moreno et al.
Telomere length regulation is essential for genome stability as short telomeres can trigger cellular senescence and apoptosis constituting an integral aspect of biological aging. Telomere biology disorders (TBDs) such as dyskeratosis congen...
Charles K Ofosu,Tanner A Wilcoxson,Tsung-Lun Lee et al.
Charles K Ofosu et al.
Adding nonadsorbing polymers to hard microsphere dispersions generates osmotic depletion attractions that can be quantitatively predicted and designed to manipulate colloidal phase behavior. Whether depletion described by classical theories...
Silicate-based therapy for inflammatory dilated cardiomyopathy by inhibiting the vicious cycle of immune inflammation via FOXO signaling [0.03%]
基于硅酸盐的治疗通过FOXO信号抑制炎症恶性循环治疗扩张型心肌病
Ping Sun,Zhaowenbin Zhang,Fei Gao et al.
Ping Sun et al.
Inflammatory dilated cardiomyopathy (iDCM) represents a severe immune-related condition provoked by the progression of myocarditis. In patients suffering from myocarditis, a vicious cycle of inflammation orchestrated by CD4+ T cells, neutro...
Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapy [0.03%]
急性髓系白血病的线粒体通过水解ATP来支持氧化代谢并抵抗化学治疗
James T Hagen,McLane M Montgomery,Raphael T Aruleba et al.
James T Hagen et al.
OxPhos inhibitors have struggled to show a clinical benefit because of their inability to distinguish healthy from cancerous mitochondria. Herein, we describe an actionable bioenergetic mechanism unique to acute myeloid leukemia (AML) mitoc...
High-voltage water-scarce hydrogel electrolytes enable mechanically safe stretchable Li-ion batteries [0.03%]
高压缺水的水凝胶电解质能够使可拉伸的锂离子电池在机械安全方面得到保障
Peisheng He,Jong Ha Park,Yingkai Jiao et al.
Peisheng He et al.
Soft Li-ion batteries, based on conventional organic electrolytes, face performance degradation challenges due to moisture penetration and safety concerns due to possible leakage of toxic fluorine compounds and flammable solvents under mech...
Remove the innermost atom of a magnetic multi-shell gold nanoparticle for near-unity conversion of CO2 to CO [0.03%]
移除磁性金纳米粒子最内层原子 实现CO2到CO的近 unity转换
Guoqing Bian,Dong Chen,Yuping Chen et al.
Guoqing Bian et al.
Few reports on paramagnetic metal nanoparticles with atomic precision and their difficult tailoring retard the insightful investigation of metal nanoparticle paramagnetism. Herein, we introduced a thiol-iodine mixture ligand-protecting stra...
Androgen receptor-regulated lncRNA PRCAT71 promotes AR signaling through the interaction with KHSRP in prostate cancer [0.03%]
由雄激素受体介导的长链非编码RNA PRCAT71通过与KHSRP相互作用促进前列腺癌中AR信号转导路径激活的作用及机制研究
Yongyong Yang,Ting-You Wang,Qianru Li et al.
Yongyong Yang et al.
Mounting evidence indicates that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis and progression of cancers. However, the functions and regulatory mechanisms of lncRNAs in prostate cancer (PCa) are still largely unknown. In ...
Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma [0.03%]
α-突触核蛋白调节黑色素瘤中的核糖体DNA双链断裂修复
Moriah R Arnold,Gabriel M Cohn,Kezia Catharina Oxe et al.
Moriah R Arnold et al.
Although an increased risk of the skin cancer melanoma in people with Parkinson's disease (PD) has been shown in multiple studies, the mechanisms involved are poorly understood, but increased expression of the PD-associated protein alpha-sy...
Invention of an oral medication for cardiac Fabry disease caused by RNA mis-splicing [0.03%]
一种治疗心脏Fabry病的口服药物发明，由RNA错误剪接引起
Tomonari Awaya,Masahiko Ajiro,Hiroko Kobayashi et al.
Tomonari Awaya et al.
Pathogenic RNA splicing variants have emerged as promising therapeutic targets due to their role in disease while preserving coding sequences. In this study, we developed RECTAS-2.0, a small molecule designed to correct RNA mis-splicing cau...
Preclinical evaluation of AGT mRNA replacement therapy for primary hyperoxaluria type I disease [0.03%]
AGT信使核糖核酸治疗I型原发性高草酸尿症的临床前评估
Taihua Yang,Jiahao Ge,Lei Huang et al.
Taihua Yang et al.
Primary hyperoxaluria type 1 (PH1) is a rare inherited liver disorder caused by alanine glyoxylate aminotransferase (AGT) dysfunction, leading to accumulation of glyoxylate which is then converted into oxalate. Excessive oxalate results in ...