Activating PEG host to enable spatially controlled surface functionalization of nanocarriers for biomedical applications [0.03%]
一种PEG宿主活化技术控制纳米载体表面功能化的空间模式用于生物医学应用
Mingchen Sun,Wei Li,Shaohua Zhang et al.
Mingchen Sun et al.
Surface functionalization with biomolecules transforms nanocarriers by integrating a range of bioderived functionalities; however, conventional methods often yield low efficiency and uneven ligand distribution, and compromise the structural...
Discovering the dual degradation pathway of emerald green in oil paints: The effects of light and humidity [0.03%]
颜料翡翠绿的双重降解途径：光照和湿度的影响
Sara Carboni Marri,Letizia Monico,Francesca Rosi et al.
Sara Carboni Marri et al.
Emerald green, a copper acetoarsenite pigment, enriched the 19th-century and 20th-century artists' palettes and caused darkening and fragilities in paintings. The accepted alteration mechanism involves the oxidation of triarsenite ions [(As...
Mingchao Ma,Guillermo A Hernández-Mendoza,Baopu Zhang et al.
Mingchao Ma et al.
Directed self-assembly (DSA) of block copolymers (BCPs) has long been included in the semiconductor roadmap as a lithographic pathway to enable continued device scaling. Tremendous progress has been made in generating two-dimensional (2D) B...
Oral delivery of aptamer-decorated SICTERS Raman probes for colonoscopy-guided resection and photothermal immunization of microtumors [0.03%]
经口递送适配体修饰的SICTERS拉曼探针用于结肠镜引导的小肿瘤切除和光热免疫治疗
Xinyi Li,Yuanyuan Qiu,Kai Cui et al.
Xinyi Li et al.
Endoscopic resection of colon cancer represents an advanced technique in early intervention, but faces the challenges in identifying tumor margins and removing residual lesions. Here, we developed orally administered Raman probes (i.e., BBT...
High-strength and fracture-resistant ionogels via solvent-tailored interphase cohesion in nanofibrous composite networks [0.03%]
基于溶剂调节的界面结合力的高强度抗开裂离子凝胶网络
He Zhang,Wenbin Jia,Mingze Sun et al.
He Zhang et al.
Ionogels are promising for soft robotics, energy systems, and bioelectronic interfaces due to their high ionic conductivity and environmental stability. However, combining high strength and fracture resistance remains challenging. Here, we ...
The nonfibrillar multiplexin collagen CLE-1 defines cholinergic synapse identity [0.03%]
非纤维多谱型胶原蛋白CLE-1定义胆碱能突触身份
Melissa Cizeron,Anaïs Dumas,Suzanne Le Reun et al.
Melissa Cizeron et al.
Fast neurotransmission requires the coordinated localization of neurotransmitter receptors opposite presynaptic release sites, which usually relies on the transsynaptic interaction of synaptic adhesion molecules. However, some extracellular...
Transition of pseudorabies virus from latency to reactivation state selectively triggered by pathogenic bacteria [0.03%]
致病菌选择性诱导伪狂犬病毒从潜伏状态到再活化状态的转换
Dan Yang,Miao Yang,Shibang Guo et al.
Dan Yang et al.
Pseudorabies virus (PRV) causes severe morbidity and mortality in pigs and must be eradicated from pig populations. The increasing PRV infections in humans-resulting in severe encephalitis, neurological sequelae, and death since 2017 in Chi...
Selective AMPKβ1 activation induces fetal hemoglobin in human erythroid cells and sickle cell mice via the noncanonical NRF2 pathway [0.03%]
选择性激活AMPKβ1通过非经典的NRF2通路在人类红系细胞和镰刀型细胞性贫血小鼠中诱导胎儿血红蛋白生成
Yannis Hara,Viktor T Lemgart,Samuel Lessard et al.
Yannis Hara et al.
Sickle cell disease (SCD), an inherited blood disorder caused by mutation of the β-globin gene, results in sickle-shaped erythrocytes, organ damage, and increased mortality. Current therapeutic options are limited, and innovative treatment...
Magnetically responsive nanocultures for direct microbial assessment in soil environments [0.03%]
响应磁场的纳米培养基可直接评估土壤环境中的微生物
Huda Usman,Mehdi Molaei,Stephen D House et al.
Huda Usman et al.
Cultivating microorganisms in native-like conditions is vital for bioprospecting and accessing now unculturable species. However, there remains a gap in scalable tools that can both mimic native microenvironments and enable targeted recover...
David A Savitz
David A Savitz
A national-scale fluoridation study addresses policy-relevant exposure levels and provides evidence that adverse neurodevelopmental effects do not result from municipal fluoridation.