A striosomal accumbens pathway drives stereotyped behavior through an aversive Esr1+ hypothalamic-habenula circuit [0.03%]
一条纹状体输入的伏隔核通路通过脑下垂体-中缝背核环路驱动刻板行为
Thomas Contesse,Buse Yel Bektash,Marta Graziano et al.
Thomas Contesse et al.
The lateral hypothalamic area (LHA) integrates external stimuli with internal states to drive the choice between competing innate or value-driven motivated behaviors. Here, we define a striosomal Tac1+/Tshz1+/Oprm1+ neuron subtype in the nu...
Renal clearable CRISPR nanosensor targeting mitochondrial DNA mutation for noninvasive monitoring of tumor progression and metastasis [0.03%]
一种靶向线粒体DNA突变的可经肾脏清除的CRISPR纳米传感器用于非侵入式监测肿瘤发生和发展转移的能力
Yanan Li,Yonghua Wu,Ziyue Zheng et al.
Yanan Li et al.
Mitochondrial DNA (mtDNA) mutations are emerging as important molecular features of tumorigenesis. Liquid biopsies, involving analysis of cell-free mtDNA, enable early cancer detection but suffer from low sensitivity due to scarce analytes....
Proximity-induced chirality at the achiral conductive interface by electrical control of enantiopure ion adsorption [0.03%]
通过电控制纯对映体离子吸附在非手性导电界面诱导手性效应
Po-Jung Huang,Yoshio Ando,Miuko Tanaka et al.
Po-Jung Huang et al.
Chirality manipulation of materials has attracted substantial interest in a wide variety of fields in science and technology. Chiral molecular adsorption is a distinct approach for inducing chirality in achiral systems such as organic-inorg...
Low-waste, single-step, sustainable extraction of critical metals from deep-sea polymetallic nodules [0.03%]
低浪费、单步骤、可持续提取深海多金属结核中的关键金属
Ubaid Manzoor,Thomas Lüttke,Dierk Raabe et al.
Ubaid Manzoor et al.
To support the green energy transition, sustainable supplies of critical metals-60 million (metric) tons of copper, 10 million tons of nickel, and 1 million tons of cobalt-annually by 2050 are essential. These metals are currently sourced f...
Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture [0.03%]
从头构建基因组尺度的体外染色质揭示组蛋白乙酰化直接调控染色质结构
Yohsuke T Fukai,Tomoya Kujirai,Masatoshi Wakamori et al.
Yohsuke T Fukai et al.
Understanding how epigenetic modifications intrinsically shape gene-scale chromatin architecture remains challenging due to difficulties in reconstituting and characterizing sufficiently long arrays with defined modification patterns. Here,...
Targeting cancer-associated fibroblasts for real-time intraoperative tumor identification with a spray-on fluorescent probe [0.03%]
一种喷雾型荧光探针可实现对肿瘤相关成纤维细胞的靶向用于实时术中肿瘤定位
Riley J Deutsch-Williams,Yuxuan Xie,Zachary Rabinowitz et al.
Riley J Deutsch-Williams et al.
Surgical tumor resection is often the only curative option for the nearly 20 million newly diagnosed patients with cancer every year. Fluorescence-guided surgery techniques are being developed in an effort to improve margin detection and su...
Capturing aberrant cell behaviors producing defects in human embryos via live imaging [0.03%]
通过活体成像捕获人类胚胎缺陷产生过程中的异常细胞行为
Hiroki Akizawa,Ana Domingo-Muelas,Maria Pardo-Figuerez et al.
Hiroki Akizawa et al.
The generation of human embryos in vitro has revolutionized reproductive medicine, and also made it possible to study fundamental aspects of early human development. However, human preimplantation embryos often display an array of morpholog...
Strongly confined mid-infrared to terahertz phonon polaritons in ultrathin SrTiO3 [0.03%]
超薄SrTiO3中强烈限制的中红外至太赫兹声子极化激元
Peiyi He,Jiade Li,Cong Li et al.
Peiyi He et al.
Phonon polaritons (PhPs) enable subwavelength light control for infrared sensing, imaging, and optoelectronics, but conventional polar materials have narrow Reststrahlen bands, limiting applications. Materials that support PhPs with broad s...
John Robert Warren,Gina Rumore,Soobin Kim et al.
John Robert Warren et al.
How are children's fluoride exposures associated with cognitive test performance in adolescence and midlife? Whereas most prior research has estimated effects of exposure to extremely high levels of fluoride, we consider exposure to levels ...
Rapid fault healing from cementation controls the dynamics of deep slow slip and tremor [0.03%]
快速固化胶结控制深部慢滑事件和震颤的动力学机制
Amanda M Thomas,James M Watkins,Nicholas Beeler et al.
Amanda M Thomas et al.
Despite its status as one of the most important discoveries in geophysics, the physical mechanism(s) responsible for slow slip events (SSEs) are not well understood. Here, we synthesize observations of deep SSEs in the Cascadia Subduction Z...