Chronic intermittent hypoxia reshapes circadian metabolic architecture in a model of sleep apnea [0.03%]
慢性间歇性缺氧重塑了一种睡眠呼吸暂停模型的昼夜代谢架构
Emilie Montellier,Guillaume Vial,Sophie Bouyon et al.
Emilie Montellier et al.
Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (IH) during sleep, is increasingly recognized as a driver of metabolic dysfunction. However, its impact on circadian metabolic regulation remains poorly understood...
Ampk alpha2 T172 activation dictates exercise performance and energy transduction in skeletal muscle [0.03%]
AMPKα2 Thr172磷酸化调控骨骼肌能量代谢及运动表现
Ryan N Montalvo,Xiaolu Li,Gina M Many et al.
Ryan N Montalvo et al.
Adenosine 5'-monophosphate-activated protein kinase (AMPK) is an energetic sensor for metabolic regulation and integration. Here, we used CRISPR-Cas9 to generate nonactivatable Ampkα knock-in (KI) mice with mutation of threonine-172 phosph...
Bees flexibly adjust decision strategies to information content in a foraging task [0.03%]
蜜蜂根据信息内容灵活调整决策策略以完成觅食任务
Johannes Spaethe,Selma Hutzenthaler,Alexander Dietz et al.
Johannes Spaethe et al.
When making decisions, animals often rely on multiple cues simultaneously. These provide complementary sources of information, which can increase the accuracy of decisions. In this study, we tested the decision and learning strategies of in...
DNA framework-based molecular transformer for logic-driven precision diagnostics [0.03%]
基于DNA框架的分子变换器的逻辑驱动精准诊断方法研究
Shuyang Zhang,Kai Xia,Lihua Wang et al.
Shuyang Zhang et al.
Precision diagnostics requires logical integration of diverse biomarker information, but molecular heterogeneity and inconsistent identification kinetics hinder robust logic analysis. To overcome this, we develop a universal molecular trans...
Hee-Hoon Kim,Tali Sagiv-Zangi,Yun-Hee Youm et al.
Hee-Hoon Kim et al.
Long-lived wild rodents closely related to laboratory mice on the evolutionary scale may allow identification of dormant pathways that resist aging. Spiny mice (Acomys) are known for their exceptional regenerative capacity, but their resili...
Danielle L Rudler,Laetitia A Hughes,Martin S King et al.
Danielle L Rudler et al.
A genome-wide knockout screen identified members of the SLC25 family of mitochondrial carrier proteins as important regulators of the rate of de novo mitochondrial protein synthesis. To elucidate this relationship, we generated human cell k...
Ink-state preaggregation control enables scalable and automated fabrication of highly efficient and stable organic photovoltaics [0.03%]
墨态预聚集体控制实现高效稳定的有机光伏的规模化和自动化制备
Hua Tang,Dingqin Hu,Rong Wang et al.
Hua Tang et al.
Scalability and automation are critical for advancing organic solar cells (OSCs) toward high-throughput production, yet both remain notable challenges. Here, we report a simple yet effective strategy using Tz6T as a multifunctional additive...
Molecular level combination of coordination and interfacial regulations via functional ligands for industrial AEM water electrolysis [0.03%]
功能性配体在工业AEM水电解中的分子级协同和界面调控效应
Xinyi Li,Jiyu Liu,Zhongfeng Wang et al.
Xinyi Li et al.
Coordination engineering is often used to tune the electronic structures of active sites, while their catalytic performances are determined not only by electronic structures but also by microenvironments. Herein, we introduce interfacial fu...
Intermediate excited state relaxation dynamics of boron vacancy spin defects in hexagonal boron nitride [0.03%]
六角氮化硼中硼空位自旋缺陷的中间激发态弛豫动力学
Paul Konrad,Mehran Kianinia,Lesley Spencer et al.
Paul Konrad et al.
Optically addressable spin defects in hexagonal boron nitride offer promising potential for 2D quantum sensing, although excited-state dynamics remain poorly understood. In particular, the nonradiative relaxation paths from the excited trip...
Yusuke Mii,Minako Suzuki,Hiroshi Koyama et al.
Yusuke Mii et al.
Planar cell polarity (PCP) is established by asymmetric localization of core PCP components in each cell. Because some Wnt proteins can induce PCP in vertebrates, it has been proposed that Wnt concentration gradients provide spatial cues fo...