All-fiber photoacoustic endomicroscopy reveals layer-specific angiogenesis-oxygenation uncoupling in experimental colitis [0.03%]
全光纤光声内镜成像揭示实验性结肠炎的层特异性血管生成-氧合作用脱钩现象
Jinying Li,Junye Bi,Di Zhang et al.
Jinying Li et al.
Inflammatory bowel disease (IBD) progression involves complex microvascular remodeling and oxygen utilization disturbances that elude conventional endoscopy. We developed an all-fiber photoacoustic endomicroscopy (AFPEM) platform integratin...
Sustained deoxygenation in global flowing waters under climate warming [0.03%]
气候变化下全球流动水体脱氧现象的持续性研究
Qi Guan,Kun Shi,Xuehui Pi
Qi Guan
Dissolved oxygen (DO), as a vital material sustaining aquatic ecosystems, has declined markedly in oceans, lakes, and coastal waters, yet unbiased understandings of changing DO concentrations in each individual river segment globally remain...
Regulating intermolecular interaction of passivators for controllable surface energetics of photovoltaic perovskites [0.03%]
通过调节钝化剂分子间相互作用来调控光伏钙钛矿表面能states:UIControlStateed/filepath
Xiaofen Jiang,Qingyun Xiao,Zhendong Cheng et al.
Xiaofen Jiang et al.
Tackling nonradiative recombination at the perovskite surface is critical yet challenging for unlocking the full potential of perovskite solar cells (PSCs). Although conventional surface passivation effectively reduces trap state density, p...
GRASPing experience-dependent protein expression signatures enriched for hippocampal engram cell synapses [0.03%]
通过GRASP捕捉经验依赖的蛋白质表达特征以丰富海马记忆痕细胞突触的标志物
Biswajit Moharana,Panthea Nemat,Renee M Pullen et al.
Biswajit Moharana et al.
Enhanced synaptic wiring onto sparsely distributed memory engram cells supports contextual memory storage and recall, with negative-valence memories exhibiting greater salience. Protein-level adaptations of input-specific synaptic connectiv...
P300/CBP inhibition with inobrodib in combination with gilteritinib and venetoclax targets leukemia stem cells in epigenetic mutant AML [0.03%]
用于联合吉列替尼和维奈克拉靶向表观遗传学变异急性髓系白血病中的白血病干细胞的P300/CBP抑制剂inobrodib
Melanie L Goetz,Jennifer S Romer-Seibert,Amanda M Versace et al.
Melanie L Goetz et al.
Acute myeloid leukemia (AML) is a fatal blood cancer with cytotoxic chemotherapy offering at best 25% 5-year survival. While targeted BCL2 and FLT3 inhibitors venetoclax and gilteritinib are used upfront in the treatment of a subset of adul...
Jonathan G G Kaufman,Grigory Tagiltsev,Danièle S Stalder et al.
Jonathan G G Kaufman et al.
The AP3 complex mediates cargo sorting and carrier assembly for the trafficking of transmembrane proteins from endosomes to lysosomes. AP3 is generally believed to localize to clathrin-free, ARF1-positive, elongated carriers in cells, but t...
Premature transcription termination modulates stochastic gene expression in bacteria [0.03%]
细菌提前转录终止调控随机基因表达
Shafagh Moradian,Nida Ali,Rahul Jagadeesan et al.
Shafagh Moradian et al.
Bacteria regulate transcription by controlling its initiation and prematurely terminating it through attenuation. Transcriptional regulation produces RNA bursts defined by size and frequency. While bursting via regulated initiation is well ...
A BBB-permeable β3-AR probe enables redox imaging, natural inhibitors discovery, and therapeutic monitoring in glioblastoma [0.03%]
一种可通过BBB的β3-AR探针可用于胶质母细胞瘤中的氧化还原成像、天然抑制剂发现及治疗监测
Wei Cheng,Zhuoying Chen,Yani Liu et al.
Wei Cheng et al.
β3-Adrenergic receptors (β3-ARs), as a subclass of G protein-coupled receptors (GPCRs), play a pivotal role in regulating oxidative stress. However, the dynamic interplay between their microenvironmental fluctuations and glioma mechanisms...
A 45.6 m NaCTFSI/NaFSI hybrid electrolyte for high-voltage aqueous sodium-ion batteries operable at subzero temperatures [0.03%]
一种用于高电压钠离子电池的45.6 m NaCTFSI/NaFSI混合电解质可在低温下运行
Thileep Kumar Kumaresan,Kyunglim Pyo,Joon Seop Kwak et al.
Thileep Kumar Kumaresan et al.
Aqueous sodium-ion batteries (SIBs) offer a safe and sustainable energy storage option, but their performance is restricted by the narrow electrochemical stability window (ESW) of water and poor low-temperature operability of conventional w...
High-energy anode-free Li metal batteries with in-built surface-fluorinated Li-rich Mn-based cathodes [0.03%]
内置表面氟化的富锂锰基正极的高能无负极锂电池
Wenchao Hu,Yang Yang,Yatao Liu et al.
Wenchao Hu et al.
Anode-free lithium metal batteries (AF-LMBs) have been recognized as a promising approach for realizing highly safe and cost-effective lithium metal batteries with high energy density but suffer from low Coulombic efficiency (CE) and short ...