Colossal dielectric perovskites enable Coulombic interfacial β-phase stabilization [0.03%]
巨介电常数钙钛矿使库仑界面β相稳定化
Qi Wei Shi,Fei Jin,Ziqin Wang et al.
Qi Wei Shi et al.
Soft piezoelectric polymers hold promise for the advancement of flexible wearable sensors offering self-powered precise monitoring capability. However, their long-term stability of performance is often constrained by modest crystallinity an...
Variability in the TLR3 type I interferon pathway is predictive of RNA vaccine responses [0.03%]
TLR3 Ⅰ 型干扰素通路的多态性预示着 RNA 疫苗的反应效果
Wilson W Ng,Jamie Sugrue,Jaime S Rosa Duque et al.
Wilson W Ng et al.
Biological predictors of variable vaccine responses are lacking. We hypothesized that variability in prevaccine innate immune responses, specifically for type I interferons (IFN-I), is predictive of postvaccine antigen-specific responses. T...
Helicase A determines the transcription program of TH17 lineage differentiation and autoimmunity [0.03%]
解旋酶A决定TH17谱系分化及自身免疫的转录程序
Yanhong Su,Anjun Jiao,Xiaoran Zhang et al.
Yanhong Su et al.
T helper 17 (TH17) lineage is governed by canonical transcriptional factors and plays a pivotal role in the pathogenesis of autoimmune diseases in both mice and humans. However, the precise orchestration of this transcriptional program rema...
Hcn1-dependent engram neurons in the PVN encode gastric inflammatory sensitization [0.03%]
PVN中依赖HCN1的刻痕神经元编码胃炎性敏感化现象
E Liu,Xijia Xin,Mengdong Shi et al.
E Liu et al.
The brain encodes peripheral inflammatory signals, but the regulatory mechanism by which the brain controls gastric inflammation remains unclear. This study reveals a circuit through which Fos-positive neurons in the paraventricular nucleus...
An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling [0.03%]
一种具有胰岛素受体和胰岛素样生长因子1(IGF-1)受体双重激动活性的工程改造型胰岛素类似物及其特异性信号转导路径
Irena Selicharová,Nicholas S Kirk,Anna Kertisová et al.
Irena Selicharová et al.
Insulin and insulin-like growth factors (IGF-1 and IGF-2) regulate metabolism, growth, and development via related receptors. In contexts such as brain function or fetal development, coordinated signaling by all three hormones is essential....
TP53-mutant AML with ribosomal gene loss exhibits impaired protein translation and sensitivity to HSP90 inhibition [0.03%]
TP53突变型AML伴核糖体基因丢失表现出蛋白质合成受损和对HSP90抑制的敏感性
Jean-François Spinella,Jalila Chagraoui,Céline Moison et al.
Jean-François Spinella et al.
TP53-mutated acute myeloid leukemia (AML) represents a particularly aggressive and therapeutically refractory subtype of the disease. While recurrent chromosomal abnormalities such as -5/del(5q), -7/del(7q), and del(17p) are well studied in...
Controlling thermoreversibility and hole conductivity in thermoresponsive ionic biogels using phase morphology for neurohaptics [0.03%]
基于相形态控制热响应离子生物凝胶的可逆性和孔隙导电性用于神经触觉传感器
Ankan Dutta,Md Abu Sayeed Biswas,Ethan Gerhard et al.
Ankan Dutta et al.
Integrating thermoreversibility with electrical conductivity in a unified hydrogel platform enables long-term, reusable through-hair neural interfaces. However, achieving both simultaneously remains challenging, as thermoreversibility deman...
Functional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina [0.03%]
靶向糖尿病视网膜周细胞中PTTG1的功能可恢复血管完整性
Linyu Zhang,Ling Ren,Jingyue Zhang et al.
Linyu Zhang et al.
Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a ret...
Davide Rattacaso,Daniel Jaschke,Marco Ballarin et al.
Davide Rattacaso et al.
As a cornerstone of automated reasoning, equational reasoning finds equivalences between symbolic expressions and fuels advances across scientific disciplines. Yet, its potential remains limited by the exponential growth of equivalent expre...
Thermoforming nanoparticle aggregates via interfacial ionic self-diffusion [0.03%]
基于界面离子自扩散的纳米颗粒聚集体系热成型研究
Shun Ishioka,Yuki Hiromatsu,Jiaxin Peng et al.
Shun Ishioka et al.
Dense aggregates of nanoparticles often exhibit excellent physical properties but have no thermoplasticity. Their formation processes are thus limited to drying of dilute nanoparticle dispersions, resulting in thin flat sheets or slender fi...