Elijah Pelofske,Frank Barrows,Pratik Sathe et al.
Elijah Pelofske et al.
While quantum annealers have emerged as versatile and controllable platforms for experimenting on correlated spin systems, the important phenomenology of magnetic memory and hysteresis remain unexplored on hardware designed to escape metast...
Man Dinh Nguyen,Daehan Park,John William Scott et al.
Man Dinh Nguyen et al.
Landau predicted that transverse sound propagates in a Fermi liquid with sufficiently strong interactions such as for liquid 3He, unlike a classical fluid that cannot support shear oscillations. Previous attempts to observe this unique coll...
Single-cell protein activity analysis reveals aberrant myogenesis and IGF2-PI3K pathway dependencies in MYOD1-mutant rhabdomyosarcoma [0.03%]
单细胞蛋白活性分析揭示了MYOD1突变型横纹肌肉瘤中的异常肌发生及IGF2-PI3K通路依赖性
Josephine K Dermawan,Fabio Vanoli,Henry Traux de Wardi et al.
Josephine K Dermawan et al.
Myogenic differentiation 1 (MYOD1)L122R-mutant spindle cell rhabdomyosarcoma (SRMS) is an ultrarare, treatment-resistant sarcoma with dismal outcomes. We performed regulatory network analysis of single-nucleus RNA sequencing (snRNA-seq) fro...
Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule [0.03%]
寡聚化使一个小分子能够选择性地靶向一种内在无序的区域
Stasė Bielskutė-García,Borja Mateos,Muhammad Awawdy et al.
Stasė Bielskutė-García et al.
Intrinsically disordered regions (IDRs) in proteins are increasingly recognized as attractive targets for therapeutic intervention. A number of small molecules interacting with IDRs have been identified, but the lack of persistent secondary...
Sleep deprivation impairs follicular development attributable to granulosa cell pyroptosis mediated by S100A8/A9-driven macrophage M1 polarization [0.03%]
睡眠剥夺通过S100A8/A9驱动的巨噬细胞M1极化诱导颗粒细胞焦亡从而损害卵泡发育
Qunying Fang,Lei Luo,Rentao Jin et al.
Qunying Fang et al.
Sleep disorders and deficiencies can up-regulate pro-inflammatory mediators, but their potential adverse impact on ovarian function remains not fully understood. In this study, we investigated the immunoregulatory mechanisms underlying slee...
A beneficial environment promotes immune resilience through epigenetic regulation [0.03%]
有益的环境通过表观遗传调控促进免疫韧性
Guilherme Dragunas,Markus Klotz,Sirui Chen et al.
Guilherme Dragunas et al.
Environmental factors are often detrimental; however, certain environments enhance immune resilience. Notably, children raised on traditional farms show reduced allergies and asthma prevalence. Here, we investigated how a beneficial environ...
Immune-adaptive pathogen variation reveals targetable mediators of gram-positive bacterial killing in macrophages [0.03%]
免疫适应性病原体变异揭示了革兰氏阳性细菌在巨噬细胞内被杀的可调节介质
Clark D Russell,Jennifer Marshall,Brian J McHugh et al.
Clark D Russell et al.
Host-directed therapies for bacterial infections can provide an adjunct or alternative to conventional antimicrobials, mitigating the impact of antimicrobial resistance. However, therapeutically targetable mediators of innate immune bacteri...
Active protothrusts and fluid highways: Seismic noise reveals hidden subduction dynamics in Cascadia [0.03%]
活跃的原逆断层和流体通道：地震噪声揭示了卡斯凯迪亚俯冲带的隐藏动力学过程
Maleen Kidiwela,Marine A Denolle,William S D Wilcock et al.
Maleen Kidiwela et al.
Complex interactions between strain accumulation, fault slip, and fluid migration influence shallow subduction zone dynamics. Using a decade of continuous ambient seismic data from Cascadia's seafloor observatories, we identified distinct r...
Rapid dopaminergic signatures in movement: Reach vigor reflects reward prediction error and learned expectation [0.03%]
快速多巴胺信号在运动中的作用：抓握力度反映奖赏预测误差和学习预期
Colin C Korbisch,Alaa A Ahmed
Colin C Korbisch
Movements become more vigorous when rewards are expected, suggesting that motivational signals influence motor control. Dopaminergic neurons, known to encode reward expectation and prediction error, are prime candidates for linking value an...
Generation of functionally competent testicular somatic cells from pluripotent stem cells [0.03%]
由多能干细胞生成功能完备的睾丸间质细胞
Takuya Sato,Takashi Yoshino,Mai Ohtsuka et al.
Takuya Sato et al.
Cellular interactions between germ cells and gonadal somatic cells are essential for the progression of gametogenesis. Here, we report a culture method for generating fetal testicular somatic cell-like cells (fTeSLCs) from embryonic stem ce...