A palette of bright and photostable monomeric fluorescent proteins for bacterial time-lapse imaging [0.03%]
一系列明亮且光稳定的单体荧光蛋白用于细菌延时成像
Nathan Fraikin,Agathe Couturier,Romain Mercier et al.
Nathan Fraikin et al.
Fluorescent proteins (FPs) are pivotal for examining protein production, localization, and dynamics in live bacterial cells. However, the use of FPs in time-lapse imaging is frequently constrained by issues such as oligomerization or limite...
Erratum for the Research Article: "SMAD4, activated by the TCR-triggered MEK/ERK signaling pathway, critically regulates CD8+ T cell cytotoxic function" by X. Liu et al [0.03%]
X. Liu等发表的研究文章“由TCR激活的MEK/ERK信号途径活化的SMAD4对于CD8+t细胞的细胞毒功能至关重要”的勘误页
Published Erratum
Science advances. 2025 Apr 11;11(15):eadx5774. DOI:10.1126/sciadv.adx5774 2025
Erratum for the Research Article: "A model for the noninvasive, habitat-inclusive estimation of upper limit abundance for synanthropes, exemplified by Macaca fascicularis" by A. L. Koch Liston et al [0.03%]
Koch Liston等人的研究文章《非侵入性生态位包容估计共域物种上限丰度的模型，以猕猴为例》(Article ID 2938465)的勘误表
Published Erratum
Science advances. 2025 Apr 11;11(15):eadx9415. DOI:10.1126/sciadv.adx9415 2025
Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT3A receptor [0.03%]
揭秘五氢色胺3A受体 vestibule区口袋 开发刺激剂类激动剂药物
Nandan Haloi,Emelia Karlsson,Marc Delarue et al.
Nandan Haloi et al.
A diverse set of modulators, including stimulants and anesthetics, regulates ion channel function in our nervous system. However, structures of ligand-bound complexes can be difficult to capture by experimental methods, particularly when bi...
Philipp Schmidbauer,Madita Hahn,Andreas Nieder
Philipp Schmidbauer
The perception of geometric regularity in shapes, a form of elementary Euclidean geometry, is a fundamental mathematical intuition in humans. We demonstrate this geometric understanding in an animal, the carrion crow. Crows were trained to ...
Generation of an inflammatory niche in a hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines [0.03%]
通过招募关键免疫细胞在水凝胶储库中生成炎性微环境可提高mRNA疫苗的疗效
Emily L Meany,John H Klich,Carolyn K Jons et al.
Emily L Meany et al.
Messenger RNA (mRNA) delivered in lipid nanoparticles (LNPs) rose to the forefront of vaccine candidates during the COVID-19 pandemic due to scalability, adaptability, and potency. Yet, there remain critical areas for improvements of these ...
Ashley A Rowe,Mauricio J Velasquez,Jacob W Aumeier et al.
Ashley A Rowe et al.
Neurodegenerative disorders such as Alzheimer's disease and macular degeneration represent major sources of human suffering, yet factors influencing disease severity remain poorly understood. Sex has been implicated as one modifying factor....
Astrocytic RNA editing regulates the host immune response to alpha-synuclein [0.03%]
天体RNA编辑调节宿主对α-突触核蛋白的免疫反应
Karishma D&#x;Sa,Minee L Choi,Aaron Z Wagen et al.
Karishma D&#x;Sa et al.
RNA editing is a posttranscriptional mechanism that targets changes in RNA transcripts to modulate innate immune responses. We report the role of astrocyte-specific, ADAR1-mediated RNA editing in neuroinflammation in Parkinson's disease (PD...
Ferroelectric tunnel junctions integrated on semiconductors with enhanced fatigue resistance [0.03%]
具有抗疲劳特性的半导体材料集成铁电隧道结意图及电输运性质。
Ningchong Zheng,Jiayi Li,Haoying Sun et al.
Ningchong Zheng et al.
Oxide-based ferroelectric tunnel junctions (FTJs) show promise for nonvolatile memory and neuromorphic applications, making their integration with existing semiconductor technologies highly desirable. Furthermore, resistance fatigue in curr...
Genome-wide methylome modeling via generative AI incorporating long- and short-range interactions [0.03%]
通过生成式人工智能整合长程和短程相互作用的全基因组甲基化建模
Fengyao Yan,Aristeidis G Telonis,Qin Yang et al.
Fengyao Yan et al.
Using millions of methylation segments, we developed DiffuCpG, a generative artificial intelligence (AI) diffusion model designed to solve the critical challenge of missing data in high-throughput methylation technologies. DiffuCpG goes bey...