A universal 2D-on-SiC platform for heterogeneous integration of epitaxial III-N membranes [0.03%]
一种用于外延III-N膜异质集成的通用二维SiC平台
Se H Kim,Hanjoo Lee,Dong-Gwan Kim et al.
Se H Kim et al.
Nonconventional epitaxial techniques, such as van der Waals epitaxy and remote epitaxy, have attracted substantial attention in the semiconductor research community for their capability to repeatedly produce high-quality freestanding films ...
Rapid cancer diagnosis using deep learning-powered label-free subcellular-resolution photoacoustic histology [0.03%]
一种使用深度学习驱动的无标签亚细胞级光声组织病理学技术进行快速癌症诊断的方法
Byullee Park,Rui Cao,Yilin Luo et al.
Byullee Park et al.
Traditional hematoxylin and eosin staining in formalin-fixed paraffin-embedded sections, while essential for diagnostic pathology, is time-consuming, labor intensive, and prone to artifacts that can obscure critical histological details. La...
Mitochondrial NAD+ gradient sustained by membrane potential and transport [0.03%]
由膜电位和转运维持的线粒体NAD+梯度
Shivansh Goyal,Scott N Lyons,Xiaolu A Cambronne
Shivansh Goyal
SLC25A51 is required for the replenishment of free nicotinamide adenine dinucleotide (oxidized form) (NAD+) into mammalian mitochondria. However, it is not known how SLC25A51 imports this anionic molecule to sustain elevated NAD+ concentrat...
miRNA-loaded biomimetic nanoparticles orchestrate gut microbe to ameliorate inflammatory bowel disease [0.03%]
负载microRNA的仿生纳米颗粒通过调节肠道微生物来改善炎症性肠病
Wenjuan Liu,Jinlong Yang,Zibo Wei et al.
Wenjuan Liu et al.
Modulation of gut microbiota has emerged as a promising therapeutic strategy for inflammatory bowel disease (IBD). However, current interventions such as probiotics and fecal microbiota transplantation remain limited by insufficient safety ...
Leiqing Hu,Asha Jyothi Gottipalli,Gengyi Zhang et al.
Leiqing Hu et al.
Gas transport through polymers follows the sorption-diffusion mechanism, and gas-philic functional groups are often incorporated into polymers to enhance its solubility selectivity and thus separation efficiency. In contrast, we report that...
Electrochemical C4 alkylation of pyridine derivatives: Enhanced regioselectivity via silane assistance [0.03%]
硅烷辅助电化学C4官能团化合成吡啶𬭩盐及C4-取代的吡啶类化合物
Zhihao Yang,Xuan Liu,Yi-Xuan Chen et al.
Zhihao Yang et al.
Pyridine derivatives are valuable biologically active compounds, materials, and ligands; however, traditional methods for site-selective direct functionalization are often hindered by multistep procedures and harsh conditions. Herein, we re...
An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP [0.03%]
一种无环核苷膦酸盐通过抑制环GMP的合成有效阻止疟原虫出芽
Marie Ali,Rea Dura,Marc-Antoine Guery et al.
Marie Ali et al.
The urgent need for original antimalarial therapies arises from the alarming spread of malaria parasite resistance to existing drugs. A promising candidate, UA2239, an acyclic nucleoside phosphonate with a guanine as nucleobase, demonstrate...
A rapid self-healing polymer mediated by ion aggregates achieves effective encapsulation of sustainable perovskite solar cells [0.03%]
一种快速自愈聚合物通过离子缔合实现有效的可持续钙钛矿太阳能电池封装
Shuangjie Wang,Tiejun Xin,Yi Zhao et al.
Shuangjie Wang et al.
Despite the rapid progress of perovskite solar cells (PSCs) toward commercialization, perovskite layers are unstable and contain toxic lead. Encapsulation represents an efficient strategy for improving the stability of PSCs as well as suppr...
A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system [0.03%]
泛素样蛋白质控制细菌型VIIb分泌系统的组装
Gabriel U Oka,Nathanaël Benoit,Axel Siroy et al.
Gabriel U Oka et al.
Type VII secretion systems (T7SS) are protein translocation machines crucial for virulence and bacterial competition in Gram-positive bacteria. Despite their importance, the structural basis for assembly of type VIIb secretion systems (T7SS...
Critical windows of prenatal heat exposure and preterm birth: Metabolomic study in the Atlanta African American Maternal-Child Cohort [0.03%]
妊娠期间热暴露与早产的关键窗口：亚特兰大非洲裔美国母婴队列的代谢组学研究
Kaitlin R Taibl,Priyanka A Bhanushali,Anne L Dunlop et al.
Kaitlin R Taibl et al.
Extreme heat is a risk factor for preterm birth (PTB), but the underlying biological pathways remain poorly understood. This study aimed to identify maternal metabolomic signatures associated with prenatal heat exposure and PTB. We conducte...