Earlier onset of chemotherapy-induced neuropathic pain in females by ICAM-1-mediated accumulation of perivascular macrophages [0.03%]
ICAM-1介导的血管周巨噬细胞积累导致女性化疗诱发的神经痛发病提前
Li Chen,Xin Zou,Cui-Cui Liu et al.
Li Chen et al.
Sex differences in the pathogenesis of a variety of diseases have drawn increasing attention. However, it remains unclear whether such differences exist in chemotherapy-induced neuropathic pain. Here, we conducted a retrospective analysis o...
Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner [0.03%]
生食蛋氨酸限制促进健康衰老且具有性别差异性
Ulalume Hernández-Arciga,Ceda Stamenkovic,Shweta Yadav et al.
Ulalume Hernández-Arciga et al.
Aging is associated with dysregulated methionine metabolism and increased levels of enzymes in the tyrosine degradation pathway (TDP). To investigate the efficacy of targeting either methionine metabolism or the TDP for healthspan improveme...
A germline ETV6 mutation disrupts hematopoiesis via de novo creation of a nuclear export signal [0.03%]
ETV6从头创建新的核输出信号以干扰造血功能的种系突变
Michael McConville,Toby Thomas,Ryan Beckner et al.
Michael McConville et al.
Germline mutations in the transcriptional regulator ETV6 are a root cause of familial inherited thrombocytopenia and predispose carriers to myelodysplastic syndromes and acute leukemias. Here, we report that the ETV6 P214L mutation creates ...
Keivan G Stassun
Keivan G Stassun
An indirectly detected planet on a highly inclined orbit about a pair of brown dwarfs shows that, when it comes to exoplanet diversity, anything goes.
Global environmental plastic dispersal under OECD policy scenarios toward 2060 [0.03%]
经合组织政策设想下的全球环境塑料分散情况至2060年
Jeroen E Sonke,Alkuin Koenig,Théo Segur et al.
Jeroen E Sonke et al.
Recent studies and OECD (Organization for Economic Cooperation and Development) reports provide roadmaps to reduce dispersal of mismanaged plastic waste to aquatic environments. Here, we use a coupled land-ocean-atmosphere model to simulate...
Oscillating microbubble array-based metamaterials (OMAMs) for rapid isolation of high-purity exosomes [0.03%]
基于振荡微气泡阵列的元材料（OMAM）用于快速分离高纯度外泌体
Xinjia Li,Zhiting Deng,Wenjun Zhang et al.
Xinjia Li et al.
Exosomes secreted by cells hold substantial potential for disease diagnosis and treatment. However, the rapid isolation of high-purity exosomes and their subpopulations from biofluids (e.g., undiluted whole blood) remains challenging. This ...
Deriving mobility-lifetime products in halide perovskite films from spectrally and time-resolved photoluminescence [0.03%]
基于光谱和时间分辨光致发光的卤化物钙钛矿薄膜迁移率 lifetime 产品研究
Ye Yuan,Genghua Yan,Samah Akel et al.
Ye Yuan et al.
Lead-halide perovskites are semiconductor materials with attractive properties for photovoltaic and other optoelectronic applications. However, determining crucial electronic material parameters, such as charge-carrier mobility and lifetime...
Evidence for a polar circumbinary exoplanet orbiting a pair of eclipsing brown dwarfs [0.03%]
关于一对食双褐矮星周围绕行的极地系外行星证据
Thomas A Baycroft,Lalitha Sairam,Amaury H M J Triaud et al.
Thomas A Baycroft et al.
One notable example of exoplanet diversity is the population of circumbinary planets, which orbit around both stars of a binary star system. There are, so far, only 16 known circumbinary exoplanets, all of which lie in the same orbital plan...
Ara-C suppresses H3 K27-altered spinal cord diffuse midline glioma growth and enhances immune checkpoint blockade sensitivity [0.03%]
Ara-c抑制H3 K27改变的脊髓弥漫性中线胶质瘤生长并增强免疫检查点阻断敏感性
Bo Pang,Yilin Wu,SongYuan An et al.
Bo Pang et al.
H3 K27-altered spinal cord diffuse midline glioma (H3-SCDMG) poses therapeutic challenges. Analysis of 73 clinical samples revealed heightened proliferation in H3-SCDMG versus wild-type tumors, suggesting therapeutic vulnerabilities. Drug s...
Optical coherent quantum control of ultrafast protein electron transfer [0.03%]
飞秒时域蛋白质电子传递的光学相干量子控制
Yifei Zhang,Na Liu,Kangwei Niu et al.
Yifei Zhang et al.
The optical control of a biological system has been challenging, although the control of the energy transfer and isomerization reaction has been successfully demonstrated. Here, we report on our studies of ultrafast electron-transfer (ET) d...