Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in C. elegans [0.03%]
C. elegans 中由保守的 LMD-3 蛋白介导的溶酶体对蛋白质稳态和生殖能力的调控
Yile Zhai,Tiantian Wang,Jiangxue Han et al.
Yile Zhai et al.
Human female fertility declines markedly with age, a pattern mirrored in C. elegans fecundity. This shared vulnerability stems from evolutionarily conserved molecular pathways. A growing body of evidence links impaired proteostasis-the cell...
Dynamic visual effects enhance flower conspicuousness but compromise color perception [0.03%]
动态视觉效应能增强花朵的显著性但会损害颜色感知
Alexander Dietz,Johannes Spaethe,Casper J van der Kooi
Alexander Dietz
Dynamic visual effects such as glossiness are taxonomically widespread and have evolved repeatedly across the tree of life. Their changeable nature poses a challenge for reliable signaling, because for signals to be reliable, they should be...
Dynamic imaging reveals subnanometer gap distance controls electron transfer processes at plasmonic nanointerfaces [0.03%]
动态影像学发现亚纳米间隙距离控制等离激元纳米界面的电子转移过程
Gang Wu,Yi Sun,Jun-Hao Wan et al.
Gang Wu et al.
Understanding electron transfer dynamics at subnanometer gaps between nanomaterial interfaces and electrodes is crucial for applications in catalysis, electrochemistry, and nanophotonics. However, experimentally visualizing and correlating ...
CTCF-RNA interactions orchestrate cell-specific chromatin loop organization [0.03%]
CTCF-RNA相互作用调控细胞特异性染色质环的组织形式
Kimberly Lucero,Sungwook Han,Pin-Yao Huang et al.
Kimberly Lucero et al.
CCCTC-binding factor (CTCF) is essential for chromatin organization. CTCF interacts with endogenous RNAs, and deletion of its ZF1 RNA binding region (∆ZF1) disrupts chromatin loops in mouse embryonic stem cells (ESCs). However, the functio...
David S Whitley
David S Whitley
Recent research decodes the most visible, least accessible remnants of prehistoric hunter-gatherer lives using iconographic analysis, data collection, and an innovative dating technique.
Toward AI ecosystems for electrolyte and interface engineering in solid-state batteries [0.03%]
面向固态电池电解质和界面工程的AI生态系统
Zhilong Wang,Wolfgang G Zeier,Fengqi You
Zhilong Wang
Solid-state batteries (SSBs) are pivotal for sustainable energy storage, delivering extended life span, low-temperature resilience, and enhanced safety. However, designing stable solid electrolytes and interfaces in SSBs remains a formidabl...
Benjamin D Dalziel
Benjamin D Dalziel
Modeling across urban-rural gradients shows city size and structure shape RSV epidemics and can guide more effective immunization strategies.
George Livadiotis,Manuel E Cuesta,Leng Y Khoo et al.
George Livadiotis et al.
Space plasma thermodynamics is thought to be affected by wave activity. Here, we show that solar radio bursts (SRBs) can transfer entropy to solar energetic protons (SEPs), affecting their thermodynamics. In particular, our analysis (i) det...
Mechanistic insights into 50 S precursor recognition and targeting by erythromycin resistance methyltransferase [0.03%]
红霉素抗性甲基转移酶识别和定位50S前体的机制见解
Sombuddha Sengupta,Rajat Mukherjee,Michael Pilsl et al.
Sombuddha Sengupta et al.
Erythromycin resistance methyltransferases (Erms) confer resistance to macrolide, lincosamide, and streptogramin B antibiotics by methylating an internal base (A2058, E. coli numbering) in an elusive precursor ribosomal state. Here, we capt...
Brain-derived extracellular vesicles circUsp32 polarized macrophages causing acute kidney injury after traumatic brain injury [0.03%]
脑外伤后血脑屏障破坏导致脑源性外泌体中的circUsp32进入肾脏极化巨噬细胞引起急性肾损伤
Jiayuanyuan Fu,Jingheng Wu,Mengran Du et al.
Jiayuanyuan Fu et al.
Brain-kidney cross-talk following traumatic brain injury (TBI) can induce acute kidney injury (AKI), but mechanisms remain unclear. Extracellular vesicles derived from injured brain tissue (TBI-EVs) may mediate brain-kidney interactions. In...