The immunoproteome and multimorbidity: A Mendelian randomization study [0.03%]
免疫蛋白组学和多发病症：一项孟德尔随机化研究
Nikita Hukerikar,Aroon D Hingorani,Sandesh Chopade et al.
Nikita Hukerikar et al.
Multimorbidity presents challenges for research and health care. We investigated how immune-proteins influence multiple diseases to identify shared mechanisms and therapeutic opportunities. Using eight large plasma proteome GWAS, we identif...
Probing individual quantum emitters in bulk semiconductors via photonic nanojets [0.03%]
基于光子纳米喷流的体半导体中量子点光学性质的研究
Behrooz Semnani,Sai Sreesh Venuturumilli,Mohammad Soltani et al.
Behrooz Semnani et al.
Solid-state quantum emitters serve as fundamental building blocks for quantum information processing, quantum telecommunication, and quantum-enhanced sensing, particularly at the nanoscale. However, the high refractive index of the emitters...
Deciphering the ancestral mechanisms of neural regeneration through single-cell analyses of jellyfish rhopalium repair [0.03%]
通过水母感觉囊修复的单细胞分析解读神经再生的祖先机制
Yongxue Li,Fanghan Wang,Tingting Sun et al.
Yongxue Li et al.
The rhopalium, an early specialized centralized nervous structure in medusozoans, exhibits a remarkable regenerative capacity after removal, offering a unique model for investigating the ancestral regulatory logic of neural regeneration. Ho...
Tropical basin interactions reduce spring predictability barrier of ENSO in a deep learning model [0.03%]
热带盆域相互作用降低了深层学习模型中厄尔尼诺南方涛动春季预测屏障的可预测性上限
Lu Zhou,Rong-Hua Zhang
Lu Zhou
The El Niño-Southern Oscillation (ENSO) exhibits a pronounced decline in predictability during boreal spring, referred to as spring predictability barrier (SPB). While tropical basin interactions among the Indian, Atlantic, and Pacific Oce...
Discovery of spontaneous mesoscopic strain waves in nematic domains using dark-field x-ray microscopy [0.03%]
利用暗场X射线显微镜在近晶域中发现自发介观应变波的现象
Kaan A Yay,William J Meese,Elliot Kisiel et al.
Kaan A Yay et al.
Electronic nematic order arises when correlated electrons spontaneously break the rotational symmetry of a crystal lattice. When electronic nematic order couples bilinearly to symmetry-breaking lattice strain, both appear together at a sing...
Hypoxia-responsive interaction between P-TEFb, BHLHE40, and Tim8-Tim13 regulates hypoxic gene transcription [0.03%]
低氧响应的P-TEFb、BHLHE40和Tim8-Tim13相互作用调节低氧基因转录
Shimaa Hassan AbdelAziz Soliman,Simone De Fabritiis,Marta Iwanaszko et al.
Shimaa Hassan AbdelAziz Soliman et al.
The P-TEFb transcriptional kinase complex regulates the pause release checkpoint step in transcription by RNA polymerase II (RNAPII). We sought to identify hypoxia-specific interactions that could direct P-TEFb activity to hypoxia-responsiv...
A dual membrane-adsorption evaporator for solar-powered lithium extraction from complex brines [0.03%]
一种用于太阳能提取复杂卤水锂的双膜吸附蒸发器
Aydin F Eskafi,Wenli Jiang,Jeffrey J Urban et al.
Aydin F Eskafi et al.
A reliable supply of lithium is required to meet the increased demand for batteries over the coming decades. In this work, we demonstrated the potential to effectively extract lithium from brines by coupling solar-powered evaporation, adsor...
Scott D Evans,Erik A Sperling,Kimberly V Lau et al.
Scott D Evans et al.
The dawn of animal life is preserved by fossils of the Ediacara Biota, which have been separated into three biotic assemblages: the Avalon, White Sea, and Nama. Geographic and temporal isolation of these faunas leads to uncertainties regard...
Continuous monitoring of blood-interstitial fluid intercompartmental molecular kinetics in freely moving animals [0.03%]
自由活动动物的血浆间质液室间分子动力学连续监测研究
Yihang Chen,Qitao Hu,Jean Won Kwak et al.
Yihang Chen et al.
Accurate health monitoring depends on continuous assessment of biochemical markers across multiple body compartments. While blood remains the clinical gold standard, interstitial fluid (ISF) presents a minimally invasive alternative that re...
Jiaqi Liu,Fengju Wang,Lian Li
Jiaqi Liu
Dysregulated B cells are central to many hematologic malignancies and autoimmune diseases, but current B cell-targeted therapies often fail to translate binding into effective signaling. Here, we present CD20 EryPatch, a living dynamic cell...