Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe [0.03%]
DNA复制叉断裂及PARP1过度活化的机制及其在复制灾难中的作用
Pedro Ortega,Elodie Bournique,Junyi Li et al.
Pedro Ortega et al.
Ataxia telangiectasia and Rad3-related (ATR) inhibition triggers a surge in origin firing, resulting in increased levels of single-stranded DNA (ssDNA) that rapidly deplete all available RPA. This leaves ssDNA unprotected and susceptible to...
Food sensing controls C. elegans reproductive behavior by neuromodulatory disinhibition [0.03%]
食物感应通过神经调节抑制控制秀丽隐杆线虫的生殖行为
Yen-Chih Chen,Kara E Zang,Hassan Ahamed et al.
Yen-Chih Chen et al.
Like many organisms, the roundworm Caenorhabditis elegans incorporates an assessment of environmental quality into its reproductive strategy. C. elegans hermaphrodites release fertilized eggs into food-rich environments but retain them in t...
In situ crystallographic mapping constrains sulfate precipitation and timing in Jezero crater, Mars [0.03%]
就位晶体学测绘约束了杰泽罗陨坑硫酸盐沉淀时间和地点
Michael W M Jones,David T Flannery,Joel A Hurowitz et al.
Michael W M Jones et al.
Late-stage Ca-sulfate-filled fractures are common on Mars. Notably, the Shenandoah formation in the western edge of Jezero crater preserves a variety of Ca-sulfate minerals in the fine-grained siliciclastic rocks explored by the Perseveranc...
Hydrogen-induced disruption of the airway mucus barrier enhances nebulized RNA delivery to reverse pulmonary fibrosis [0.03%]
氢诱导的气道粘液屏障破坏增强雾化RNA递送以逆转肺纤维化
Chang Liu,Xidong Tian,Zhenping Wang et al.
Chang Liu et al.
Nebulized RNA therapies are well suited for treating respiratory diseases, in particular pulmonary fibrosis (PF); however, effective delivery remains challenging. In this study, we present a highly efficient aerosol inhalation system that e...
Aggregation of α-synuclein splice isoforms through a phase separation pathway [0.03%]
通过相分离途径聚集α-突触核蛋白剪接异构体
Alexander Röntgen,Zenon Toprakcioglu,Samuel T Dada et al.
Alexander Röntgen et al.
The aggregation of α-synuclein (αSyn) is associated with Parkinson's disease and other related synucleinopathies. Considerable efforts have thus been directed at understanding this process. However, the recently discovered condensation pa...
Deubiquitinase USP24 activated by IL-6/STAT3 enhances PD-1 protein stability and suppresses T cell antitumor response [0.03%]
IL-6/STAT3激活去泛素酶USP24通过增强PD-1蛋白稳定性来抑制T细胞的抗肿瘤反应
Hung-Chia Hsieh,Ming-Jer Young,Kuan-Yu Chen et al.
Hung-Chia Hsieh et al.
Persisting programmed cell death-1 (PD-1) signaling impairs T cell effector function, which is highly associated with T cell exhaustion and immunotherapy failure. However, the mechanism responsible for PD-1 deubiquitination and T cell dysfu...
Persistent IgG1 clones dominate and personalize the plasma antibody repertoire [0.03%]
持久的IgG1克隆主导并实现浆细胞抗体库的个性化
Danique M H van Rijswijck,Albert Bondt,Dina Raafat et al.
Danique M H van Rijswijck et al.
Antibodies play a pivotal role in the immune defense and long-term immunity. Yet, while several studies have highlighted the persistence of antigen-specific antibody responses, it is unclear whether this stems from the continuous production...
Bo Wang,Xinyuan Zhang,Shaocong Wang et al.
Bo Wang et al.
Machine learning has advanced unprecedentedly, exemplified by GPT-4 and SORA. However, they cannot parallel human brains in efficiency and adaptability due to differences in signal representation, optimization, runtime reconfigurability, an...
In vivo and in situ monitoring of doxorubicin pharmacokinetics with an implantable bioresorbable optical sensor [0.03%]
体内和原位监测阿霉素药代动力学的可植入生物可降解光学传感器
Martina Corsi,Elena Maurina,Salvatore Surdo et al.
Martina Corsi et al.
Cancer treatment, particularly chemotherapy, requires balancing efficacy and toxicity. Although traditional monitoring methods can lead to suboptimal outcomes, emerging implantable chemical sensors can complement them by providing precise, ...
Proteorhodopsin insights into the molecular mechanism of vectorial proton transport [0.03%]
有关矢量型质子传输的分子机制的视紫红蛋白研究新进展
Sergey Bukhdruker,Ivan Gushchin,Vitaly Shevchenko et al.
Sergey Bukhdruker et al.
Bacterial proton pumps, proteorhodopsins (PRs), are a major group of light-driven membrane proteins found in marine bacteria. They are functionally and structurally distinct from archaeal and eukaryotic proton pumps. To elucidate the proton...