Lu Chen,Yan Li,Yanjie Ma et al.
Lu Chen et al.
Three-dimensional molecular generation is critical in drug design. However, current methods often rely on point clouds or oversimplified interaction models, limiting their ability to accurately represent molecular structures. To address the...
Agnit Mukhopadhyay,Sanja Panovska,Raven Garvey et al.
Agnit Mukhopadhyay et al.
In the recent geological past, Earth's magnetic field reduced to ~10% of the modern values and the magnetic poles shifted away from the geographic poles, causing the Laschamps geomagnetic excursion, about 41 millennia ago. The excursion las...
A wireless, self-powered smart insole for gait monitoring and recognition via nonlinear synergistic pressure sensing [0.03%]
一种用于步态监测和识别的无线自供能智能鞋垫：非线性协同压力传感
Qi Wang,Hui Guan,Chen Wang et al.
Qi Wang et al.
Wearable insole-based pressure sensor systems have gained attention for continuous gait monitoring, showing potential for preventing, diagnosing, and treating conditions such as lumbar degenerative disease and diabetic foot ulcers. However,...
Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response [0.03%]
YTHDF1核积累在DNA损伤反应中的mRNA剪接调控作用
Jingyu Hou,Yunyi Gao,Bing Han et al.
Jingyu Hou et al.
YTH domain-containing family protein 1 (YTHDF1), a reader of N6-methyladenosine (m6A), has been implicated in regulating RNA metabolism in the cytosol. Here, we report a role of YTHDF1 within the nucleus in response to genotoxic stress. Upo...
Changes in the western flank of the North Atlantic subtropical high since 1140 CE: Extremes, drivers, and hydroclimatic patterns [0.03%]
1140年来北半球副热带高压西侧的变化：极端事件、驱动因子与含气候模式
Joshua C Bregy,Justin T Maxwell,Scott M Robeson et al.
Joshua C Bregy et al.
Summer circulation and moisture patterns in the Southeast United States are controlled by the position of the North Atlantic subtropical high. In a warming climate, the subtropical high is projected to strengthen and expand west, but there ...
Permissive central tolerance plus defective peripheral checkpoints license pathogenic memory B cells in CASPR2-antibody encephalitis [0.03%]
中枢耐受性许可加上外围检查点缺陷许可脑炎中的致病记忆B细胞产生CASPR2抗体
Bo Sun,Dominique Fernandes,John Soltys et al.
Bo Sun et al.
Autoantibody-mediated diseases targeting one autoantigen provide a unique opportunity to comprehensively understand the development of disease-causing B cells and autoantibodies. Convention suggests that such autoreactivities are generated ...
Amyotrophic lateral sclerosis and frontotemporal dementia mutation reduces endothelial TDP-43 and causes blood-brain barrier defects [0.03%]
渐冻症和额颞痴呆突变降低了内皮细胞TDP-43并导致血脑屏障缺陷
Ashok Cheemala,Amy L Kimble,Emily N Burrage et al.
Ashok Cheemala et al.
Mutations in the TARDBP gene encoding TDP-43 protein are linked to loss of function in neurons and familial frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We recently identified reduced nuclear TDP-43 in capillary en...
A direct effect of the hematocrit on blood glucose: Evidence from hypoxia- and erythropoietin-treated mice [0.03%]
血细胞比容对血糖的直接影响：缺氧和促红细胞生成素处理小鼠的证据
Thomas Scherer,Matthäus Metz,Marianna Beghini et al.
Thomas Scherer et al.
Blood glucose is lower in mountain dwellers living under low partial oxygen pressure. We show that obese mice maintained under hypoxia exhibit a delayed but distinct decrease in blood glucose with improved insulin sensitivity, which is inde...
Cathelicidin antimicrobial peptides mediate immune protection in marsupial neonates [0.03%]
腔肠素类抗菌肽介导有袋动物幼体免疫保护作用
Jongbeom Park,Wenfan Ke,Aellah Kaage et al.
Jongbeom Park et al.
Marsupial neonates are born with immature immune systems, making them vulnerable to pathogens. While neonates receive maternal protection, they can also independently combat pathogens, although the mechanisms remain unknown. Using the sugar...
Single-site ruthenium catalyst supported on zeolite for CO2 hydrogenation to methyl formate [0.03%]
单原子钌杂化分子筛二氧化碳加氢制甲酸甲酯催化剂
Roland C Turnell-Ritson,Lindsey E K Frederiksen,Jan Romano-deGea et al.
Roland C Turnell-Ritson et al.
Technologies for the transformation of atmospheric CO2 to useful chemicals, such as formic acid (FA), are essential to combatting excessive fossil fuel use and will need to be implemented on large scale. However, hydrogenation of CO2 to (ba...