Dihydroxyacetone phosphate generated in the chloroplast mediates the activation of TOR by CO2 and light [0.03%]
叶绿体中产生的二羟基乙醇磷酸介导CO2和光激活TOR
Manuel J Mallén-Ponce,Andrea M Quintero-Moreno,Samuel Gámez-Arcas et al.
Manuel J Mallén-Ponce et al.
Light and CO2 assimilation activate the target of rapamycin (TOR) kinase in photosynthetic cells, but how these signals are transmitted to TOR is unknown. Using the green alga Chlamydomonas reinhardtii as a model system, we identified dihyd...
Navigating and attributing uncertainty in future tropical cyclone risk estimates [0.03%]
不确定性下的未来台风风险估算导航与归因
Simona Meiler,Chahan M Kropf,Jamie W McCaughey et al.
Simona Meiler et al.
Future tropical cyclone risks will evolve with climate change and socioeconomic development, entailing substantial uncertainties. An uncertainty and sensitivity analysis of these risks is vital, yet the chosen model setup influences outcome...
A conserved opal termination codon optimizes a temperature-dependent trade-off between protein production and processing in alphaviruses [0.03%]
保守的opal终止密码子在反转录病毒中优化了蛋白质生成和处理之间的温度依赖性权衡
Tamanash Bhattacharya,Eva M Alleman,Tiia S Freeman et al.
Tamanash Bhattacharya et al.
Most mosquito-transmitted alphaviruses encode a premature opal termination codon upstream of their viral polymerase. We show that the Sindbis virus (SINV) opal codon outperforms other stop codons in primate cells at 37°C due to optimal tra...
Sustained mTORC1 activation in activated T cells impairs vaccine responses in older individuals [0.03%]
Aktivierter T-Zellen mit nachhaltiger mTORC1-Activierung beeinträchtigen die Impfreaktionen älterer Individuen
Xiaorong Lin,Yanhua Du,Shuo Kan et al.
Xiaorong Lin et al.
T cell aging contributes to the lower vaccine efficacy in older adults, yet the molecular mechanism remains elusive. Here, we show the density of initially responding naïve CD4+ T cells is instructive in T follicular helper (TFH) cell fate...
Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth [0.03%]
靶向PGM3消除SREBP-1激活-己糖胺合成反馈调节可有效抑制脑瘤生长
Huali Su,Yaogang Zhong,Liqing He et al.
Huali Su et al.
Elevated hexosamine biosynthesis fuels tumor growth by facilitating protein and lipid glycosylation. But which enzyme in this pathway is better to serve as an antitumor target remains unclear. Here, we revealed that targeting GFAT1, the rat...
An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element [0.03%]
一个进化上独特的病毒RNA聚合酶表明起始元件具有双重功能的共同特征
Hengxia Jia,Shunli Liu,Guibo Rao et al.
Hengxia Jia et al.
Many RNA-dependent RNA polymerases (RdRPs) encoded by RNA viruses use de novo initiation strategy to start RNA synthesis, and they usually contain a priming element (PE) to interact with template RNA and priming nucleoside triphosphate to f...
Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier [0.03%]
人体线粒体丙酮酸载体的丙酮酸转运及其抑制作用的分子机制
Maximilian Sichrovsky,Denis Lacabanne,Jonathan J Ruprecht et al.
Maximilian Sichrovsky et al.
The mitochondrial pyruvate carrier transports pyruvate, produced by glycolysis from sugar molecules, into the mitochondrial matrix, as a crucial transport step in eukaryotic energy metabolism. The carrier is a drug target for the treatment ...
Pyrite stimulates the growth and sulfur oxidation capacity of anoxygenic phototrophic sulfur bacteria in euxinic environments [0.03%]
黄铁矿通过促进厌氧光合硫细菌的生长和硫氧化能力来刺激硫化环境中的生物地球化学循环
Runjie Li,Xiaolei Liu,Geng Wu et al.
Runjie Li et al.
Anoxygenic phototrophic sulfur bacteria flourish in contemporary and ancient euxinic environments, driving the biogeochemical cycles of carbon and sulfur. However, it is unclear how these strict anaerobes meet their high demand for iron in ...
Electric field-confined synthesis of single atomic TiO x C y electrocatalytic membranes [0.03%]
电场限制下单原子TiO x C y 电催化膜的合成
Yifan Gao,Shuai Liang,Chengxu Jiang et al.
Yifan Gao et al.
Electrocatalysis exhibits certain benefits for water purification, but the low performance of electrodes severely hampers its utility. Here, we report a general strategy for fabricating high-performance three-dimensional (3D) porous electro...
Kinetic implications of IP6 anion binding on the molecular switch of HIV-1 capsid assembly [0.03%]
IP6阴离子结合对HIV-1衣壳装配分子开关的动力学影响
Manish Gupta,Arpa Hudait,Mark Yeager et al.
Manish Gupta et al.
HIV-1 capsid (CA) proteins self-assemble into a fullerene-shaped CA, enabling cellular transport and nuclear entry of the viral genome. A structural switch comprising the Thr-Val-Gly- Gly (TVGG) motif either assumes a disordered coil or a 3...