Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease [0.03%]
Arp2/3依赖的纤毛发生调节支配着肾病远端 tubule 上皮细胞状态的适应性变化
Manuel Rogg,Lisa Weißer,Jasmin I Maier et al.
Manuel Rogg et al.
Proteinuric kidney disease substantially affects renal tubules through incompletely understood mechanisms. We identify elongation of primary cilia in distal renal tubules in the context of glomerular nephropathy. In renal biopsies and mouse...
John Chen,Alfredo Fontanini
John Chen
The anterior-lateral motor cortex (ALM) has been extensively studied as a model for understanding the cortical mechanisms involved in planning directional movements. ALM neurons show preparatory activity that predict whether the mouse will ...
Chenliang Wu,Wonsuck Kim,Shuo Yang et al.
Chenliang Wu et al.
Lateral channel migration is a fundamental process in natural alluvial rivers; however, the factors that control the rate of migration remain unclear. Despite its importance in shaping river morphology, the impact of water discharge on rive...
Metabolic reprogramming in Fanconi anemia: Evidence of compromised glucose oxidation, enhanced ketogenesis, and metabolic inflexibility [0.03%]
范可尼贫血中的代谢重编程：糖氧化受阻、生酮作用加强及代谢转换能力下降的证据
Sara Vicente-Muñoz,Suzanne S Summer,Thomas J Galletta et al.
Sara Vicente-Muñoz et al.
Fanconi anemia (FA) is a rare genetic disorder characterized by congenital abnormalities, bone marrow failure, and cancer predisposition. Approximately 80% of individuals with FA exhibit metabolic abnormalities, including failure to thrive ...
Climate stability and low population pressure predict peaceful interactions over 10,000 years of Central Andean history [0.03%]
一万年中央安第斯历史表明：气候稳定和低人口压力预测和平互动
Weston C McCool,Kurt M Wilson,Elizabeth N Arkush et al.
Weston C McCool et al.
As anthropogenic climate change threatens to destabilize global societies and ecosystems, anticipating likely human responses becomes ever more urgent. A key global initiative is the promotion of peaceful relations. Nonetheless, studies tha...
Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer's disease [0.03%]
阿尔茨海默病中默认网络功能障碍和认知衰退的神经生理标志
Recep A Ozdemir,Brice Passera,Peter J Fried et al.
Recep A Ozdemir et al.
Neural hyperexcitability and network dysfunction are neurophysiological hallmarks of Alzheimer's disease (AD) in animal studies, but their presence and clinical relevance in humans remain poorly understood. We introduce a perturbation-based...
Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model [0.03%]
专门的信号中心在体外分化的中胚层类器官中调控细胞命运和空间分布
Evangelia Skoufa,Jixing Zhong,Kelly Hu et al.
Evangelia Skoufa et al.
Specialized signaling centers orchestrate robust development and regeneration. Limb morphogenesis, for instance, requires interactions between the mesoderm and the signaling center apical-ectodermal ridge (AER), whose properties and role in...
FeaSion decodes the regulatory landscape and functional diversity of RNA polymerase II CTD phosphorylation [0.03%]
FeaSion 解码RNA聚合酶II C端结构域磷酸化的调控景观和功能多样性
Junyi Zhu,Lijun Bao,Shengchun Xu et al.
Junyi Zhu et al.
RNA polymerase II's (RNAPII) C-terminal domain (CTD) contains five phosphorylation sites (pY1, pS2, pT4, pS5, and pS7). However, their regulatome and immediate functions remain elusive. Using the FeaSion (Feature-Screening-Function) strateg...
Hsiang-Ling Chuang,Yu-Chen Fa,Kum-Yi Cheng et al.
Hsiang-Ling Chuang et al.
Membrane rafts are cellular portals to external stimuli that trigger signaling cascades for sophisticated yet remarkable biochemical activities. Visualization of the topographic evolution of membrane rafts remains unreported on live cells d...
Optogenetic silencing by combining a rhodopsin cyclase with an engineered cGMP-gated potassium channel [0.03%]
结合视紫红质环化酶与工程学cGMP门控钾通道实现光遗传失活
Anika Spreen,Nidish Ponath Sadanandan,Martin Winfried Schneider et al.
Anika Spreen et al.
Since the advent of optogenetics, great progress has been made in developing tools to modulate and detect cellular activity using light. We present a two-component optogenetic silencing tool, RoCK (rhodopsin cyclase/K+ channel), which pairs...