Inclusion of JNK-independent drugs within multiagent chemotherapy improves response in relapsed high-risk neuroblastoma [0.03%]
包含JNK独立药物的多药化疗可提高高危复发性神经母细胞瘤的治疗反应率
Jeremy Z R Han,Monica Phimmachanh,Jordan F Hastings et al.
Jeremy Z R Han et al.
The acquisition of a chemoresistant state underlies poor prognosis in many cancers, including neuroblastoma. We previously demonstrated that heterogeneity in apoptosis induction through c-Jun amino-terminal kinase (JNK) promotes a form of n...
Ultrasonic cavitation shock wave exfoliation dynamics of 2D materials revealed in situ by MHz XFEL imaging and multiphysics modeling [0.03%]
基于MHz X射线自由电子激光成像和多物理场建模的二维材料超声空化剥落动力学研究
Kang Xiang,Ling Qin,Shi Huang et al.
Kang Xiang et al.
Using megahertz x-ray free electron laser imaging with x-ray pulses of ~25 femtoseconds and a machine-learning strategy, we have conducted comprehensive in situ imaging studies on the dynamics of cavitation bubble clouds in ultrasound field...
Mechanoadaptive polysaccharide conjugates architect pro-healing microenvironments via dynamic stress redistribution in skin defects [0.03%]
机械自适应多糖共聚物通过皮肤缺陷中的动态应力重新分布构建促愈微环境
Rui Zhang,Guo Zhang,Xiaoyang Liang et al.
Rui Zhang et al.
The tip stress concentration in linear wounds, a clinically prevalent issue yet overshadowed by circular defect studies, and chronic biotemporal discordance (static biomaterials versus dynamic tissue remodeling) remain largely underexplored...
North Atlantic Subtropical High forcing of Atlantic Warm Pool hydroclimate variability on millennial to orbital timescales [0.03%]
千年至轨道尺度下北大西洋副热带高压对暖池热力气候变异性的影响
Hanying Li,Ashish Sinha,Amos Winter et al.
Hanying Li et al.
Orbital-scale variations in insolation are widely considered to drive tropical and monsoonal rainfall, with higher summer insolation linked to stronger precipitation. Here, we present a precisely dated speleothem record from Cuba that recon...
Miriam Acquafredda,Jan W Kurzawski,Laura Biagi et al.
Miriam Acquafredda et al.
In normally sighted human adults, 2 hours of monocular deprivation is sufficient to transiently alter ocular dominance. Here, we show that this is associated with a reduction of functional connectivity between the pulvinar and primary visua...
Genomic evidence supports the "long chronology" for the peopling of Sahul [0.03%]
基因组证据支持"Sahul地区有人居住的长期史观"
Francesca Gandini,Mafalda Almeida,M George B Foody et al.
Francesca Gandini et al.
The timing of the settlement of Sahul-the Pleistocene landmass formed by present-day New Guinea, Australia, and Tasmania that existed until ~9000 years ago (~9 ka)-remains highly contentious. The so-called "long chronology" posits the first...
Bias-controlled multistate spintronics with giant TMR and polarity switch via localized spin states in 2D half-metals [0.03%]
具有巨TMR和极性切换的二维半金属局域自旋态多态自旋电子学
Jialin Yang,Chuyao Chen,Shengli Zhang et al.
Jialin Yang et al.
The relentless downscaling of integrated circuit systems imposes critical demands on spintronic technologies, particularly requiring superior storage density and efficient tunability beyond conventional magnetic-field approaches. A notable ...
Quantum tunneling of homogeneous catalyst altering CO2 reduction reaction pathway for stable Mg-CO2 batteries [0.03%]
均匀催化剂的量子隧穿效应改变Mg-CO2电池的CO2还原反应路径以实现稳定电池运行
Wenbo Liu,Lu Li,Menggang Li et al.
Wenbo Liu et al.
Mg-CO2 battery has emerged as a promising battery technology by harnessing greenhouse gas as an active material. However, its development is greatly hindered by sluggish CO2 conversion kinetics, resulting in high overpotentials and poor rev...
How ATP and dATP reposition class III ribonucleotide reductase cone domains to regulate enzyme activity [0.03%]
ATP和dATP通过重新定位核酸还原酶的圆锥结构域来调节酶活性
Gisele A Andree,Kelsey R Miller-Brown,Zhuangyu Zhao et al.
Gisele A Andree et al.
Ribonucleotide reductases (RNRs) catalyze the conversion of ribonucleotides to deoxyribonucleotides. In the majority of cases, RNR activity is allosterically regulated by the cellular 2'-deoxyadenosine 5'-triphosphate (dATP)/adenosine 5'-tr...
George I Austin,Itsik Pe&#x;er,Tal Korem
George I Austin
Cross-validation is a common method for evaluating machine learning models. "Leave-one-out cross-validation," in which each data instance is used to test a model trained on all other instances, is often used in data-scarce regimes. As commo...