Asymmetric synthesis of chiral boronic esters featuring nonadjacent axial and flexible, acyclic central chirality [0.03%]
具有轴向和柔性非中心手性的非相邻手性硼酸酯的不对称合成
Xi-Zhang Zou,Yu-Wen Sun,De-Wei Gao
Xi-Zhang Zou
Nonadjacent chirality is prevalent in pharmaceuticals and bioactive molecules, but prior studies primarily focused on constructing noncontiguous stereocenters. However, the construction of nonadjacent axial and flexible, acyclic central chi...
Robert C Robinson,Thitipat Chongrungreang,Khongpon Ponlachantra et al.
Robert C Robinson et al.
Villin is an actin filament nucleating, severing, capping and bundling protein; however, the structural basis for villin's functions and the characteristics of the actin polymerization nucleus remain poorly understood. Here, we present the ...
Sensitive detection of structural dynamics using a statistical framework for comparative crystallography [0.03%]
基于比较结晶学统计模型的结构动态敏感检测方法
Doeke R Hekstra,Harrison K Wang,Margaret A Klureza et al.
Doeke R Hekstra et al.
Chemical and conformational changes are crucial to protein function and its pharmacological control. X-ray crystallography can reveal these changes in atomic detail, but standard analysis methods, which refine separate datasets, often overl...
Red blood cell-hitchhiking fluorescent probe to promote intraoperative diagnosis of human ovarian tumor [0.03%]
一种促进人卵巢肿瘤术中诊断的红细胞搭载型荧光探针
Yijing Lin,Ke Li,Yue Ding et al.
Yijing Lin et al.
Ovarian cancer is the deadliest gynecological malignancy. The fluorescence-guided surgery technique provides a real-time visualization of the desired regions to guide the tumor resection. However, the fluorescent probes used in clinics suff...
Jeong Yeon Kim,Jinhyeon An,Soyeon Kim et al.
Jeong Yeon Kim et al.
B cell involvement in neoantigen-driven antitumor immunity remains largely unexplored because of challenges in predicting B cell responses. Here, we developed a method to identify B cell epitopes by characterizing >437,000 peptides tested f...
Aerobatic maneuvers in insect-scale flapping-wing aerial robots via deep-learned robust tube model predictive control [0.03%]
基于深度强化学习的仿生扑翼微小型飞行器极限特技飞行控制系统
Yi-Hsuan Hsiao,Andrea Tagliabue,Owen Matteson et al.
Yi-Hsuan Hsiao et al.
Aerial insects exhibit agile maneuvers such as sharp braking, saccades, and body flips under disturbances; in contrast, insect-scale aerial robots are limited to tracking smooth trajectories with small acceleration. To achieve similar fligh...
Xiao Wei,Irepan Salvador-Martinez,Maciej Meglicki et al.
Xiao Wei et al.
During mouse embryogenesis, totipotency is gradually lost, and, at the 16-cell stage, blastomeres begin to bifurcate into trophectoderm (future placenta) and inner cell mass (future fetus). Although this process is well studied, when and ho...
Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer's disease [0.03%]
肠道微生物衍生的吲哚-3-丙酸可改善阿尔茨海默病的认知功能
Ling Li,Mengzhen Jia,Cong Yang et al.
Ling Li et al.
Intermittent fasting (IF) offers a potential strategy to counteract Alzheimer's disease (AD) progression. In our 16-week study on AD transgenic mice, IF positively affected cognitive function and reduced amyloid-β (Aβ) accumulation, verif...