Achieving cysteine-selective peptide/protein bioconjugation via tunable triazine-pyridine chemistry [0.03%]
利用可调三嗪-吡啶化学实现半胱氨酸选择性肽/蛋白质生物连接
Chaoming Wang,Ruijuan Yin,Hao Jiang et al.
Chaoming Wang et al.
The development of cysteine (Cys)-selective bioconjugation reagents with enhanced stability remains a critical challenge for therapeutic applications such as antibody-drug conjugates (ADCs). Leveraging the modular 1,3,5-triazine scaffold, w...
Zhiqiang Zheng,Sinan Ozgun Demir,Anping Wu et al.
Zhiqiang Zheng et al.
Advancements in cellular immunotherapy demanded efficient immune cell delivery. To meet this need, we introduced hydrogel-based immune millirobots designed for high immune cell loading and precise tumor targeting. These ultrasoft robots, em...
Maternal lipidomic signatures of preterm and small-for-gestational-age newborn infants in low- and middle-income countries [0.03%]
发展中国家早产和宫内生长受限新生儿的母体脂质组学特征研究
Ivana Marić,Ali Mahzarnia,Hilda A Mujuru et al.
Ivana Marić et al.
Maternal lipid levels change dynamically during gestation to support normal fetal growth. To obtain a detailed footprint of these changes and their differences in pregnancies with preterm or small-for-gestational-age (SGA) neonates, we anal...
Proteome-wide computational analyses reveal links between protein condensate formation and RNA biology [0.03%]
蛋白质组范围的计算分析揭示了蛋白质凝聚物形成与RNA生物学之间的联系
Snigdha Maiti,Swarnendu Tripathi,David W Baggett et al.
Snigdha Maiti et al.
Biomolecular condensates mediate dynamic compartmentalization of cellular processes. The multivalent interactions that underlie biomolecular condensation are often promoted by intrinsically disordered regions (IDRs) within proteins. Althoug...
An ultrasmall theranostic nanozyme for abdominal aortic aneurysm management and therapeutic efficacy monitoring [0.03%]
一种超小型纳米酶用于腹主动脉瘤的诊疗及疗效监测
Wanling Liu,Yihong Zhang,Xiaomiao Cui et al.
Wanling Liu et al.
Abdominal aortic aneurysm (AAA) is a life-threatening condition lacking effective drug interventions, and its progression is difficult to predict, complicating early clinical management. Here, we present a reactive oxygen species-responsive...
Rbfox2 selectively governs hematopoietic stem cell self-renewal by regulating proteostasis [0.03%]
Rbfox2通过调节蛋白质稳态选择性地控制造血干细胞的自我更新
Longfei Gao,Desmond Dickson,Huijuan Feng et al.
Longfei Gao et al.
Self-renewing hematopoietic stem cells (HSCs) generate all blood cells and give rise to long-term reconstitution of the hematopoietic system after transplantation, but the molecular mechanisms that specifically regulate HSCs remain poorly d...
Distinguishing active HIV-1 infection from vaccine-induced seropositivity in HIV vaccine trial participants [0.03%]
区分HIV疫苗试验参与者活跃的HIV-1感染和疫苗诱导的血清阳性反应
Ketan Dighe,Oguzhan Colak,Parikshit Moitra et al.
Ketan Dighe et al.
Vaccine-induced seropositivity (VISP) causes antibodies produced by HIV-1 vaccines to react with standard serological tests, complicating diagnosis and leading to false positives. To distinguish VISP from true HIV infections, we developed a...
Realization of a functioning dual-type trapped-ion quantum network node [0.03%]
实现双类型囚禁离子的量子网络节点功能原型
Yuan-Yuan Huang,Lu Feng,Yu-Kai Wu et al.
Yuan-Yuan Huang et al.
Trapped ions constitute a promising platform for implementation of a quantum network. Recently, a dual-type qubit scheme has been realized in a quantum network node where communication qubits and memory qubits are encoded in different energ...
Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase [0.03%]
一种细菌辅酶胺蛋白连接酶针对线粒体疾病的多种遗传缺陷作用机制研究
Zhijuan Hu,Junru Yu,Ziwei Liu et al.
Zhijuan Hu et al.
Metabolic disorders caused by defects in energy metabolism can lead to many life-threatening diseases; their therapy remains elusive in most cases. Conventional gene therapy relies on the "one gene for one genetic defect" strategy. Here, we...
Tidal and hydrological seismicity modulations reveal pore fluid diffusion during earthquake nucleation [0.03%]
地震孕育过程中潮汐和水文地震活动变化揭示了孔隙流体扩散的作用
Zeyan Zhao,Lian Xue,Roland Bürgmann et al.
Zeyan Zhao et al.
The occurrence of seismic events can be modulated by external periodic stress perturbations, such as daily tidal stress and annual hydrological stress. Such periodic modulations are crucial for understanding earthquake triggering, yet their...