Single-cell sequencing of rodent ventral pallidum reveals diverse neuronal subtypes with noncanonical interregional continuity [0.03%]
小鼠伏隔核单细胞测序揭示非经典脑区间连接的神经元亚型
David J Ottenheimer,Rhiana C Simon,Brandy A Briones et al.
David J Ottenheimer et al.
The ventral pallidum (VP) was defined as a basal ganglia nucleus with dense input from ventral striatum. To further investigate its regional identity, we conducted a cross-species transcriptional characterization of VP cell types. We perfor...
Structural assembly of maize CRY-GL2 photosignaling complex provides insights into its regulatory role in cuticular wax biosynthesis [0.03%]
玉米CRY-GL2光信号复合体的结构组装为其调控角质蜡生物合成的作用提供了见解
Yaqi Liu,Zhiwei Zhao,Xue Zhang et al.
Yaqi Liu et al.
Plant cryptochromes (CRYs) are blue-light photoreceptors regulating physiological processes via oligomerization-dependent interaction with effectors. However, the structural basis for photoactivated CRY-effector assembly remains elusive. He...
Molecular basis of very-long-chain fatty acid elongation by the CER6-GL2 enzyme complex in plant wax biosynthesis [0.03%]
CER6-GL2酶复合物介导的植物蜡质生物合成中非常长链脂肪酸延长反应分子机制研究
Yaqi Liu,Yuan Chen,Xue Zhang et al.
Yaqi Liu et al.
Plant cuticular waxes, crucial hydrophobic barriers, are primarily composed of aliphatics derived from very-long-chain fatty acids (VLCFAs; >C28) synthesized by the endoplasmic reticulum fatty acid elongase complex. The core catalytic subun...
Drosophila and mouse intestinal stem cells are spatiotemporally specified by Notch suppression and Wnt activation [0.03%]
notch抑制和Wnt活化时空界定果蝇和小鼠肠道干细胞属性
You Wu,Lingxiao Yu,Yuxin Yu et al.
You Wu et al.
The specification of intestinal stem cells (ISCs) during development is critical for maintaining intestinal homeostasis. However, the mechanisms underlying this process remain elusive. Here, by counting and tracing ISC in Drosophila pupal m...
Enantiospecific two-photon electric-dipole selection rule of chiral molecules [0.03%]
手性分子的enantiospecific二维电偶极选择定则
Fen Zou,Yong Li,Peng Zhang
Fen Zou
Distinguishing between enantiomers is crucial in chemistry and pharmacology. Existing optical methods rely on enantiospecific three-photon electric-dipole transitions, requiring phase locking, three-photon resonance, and precise beam contro...
VAPB is a negative regulator of STING-mediated innate immune signaling [0.03%]
VAPB是STING介导的天然免疫信号转导的负调控因子
Wangsheng Ji,Yin Zhang,Lianfei Zhang et al.
Wangsheng Ji et al.
Stimulator of IFN genes (STING) is an endoplasmic reticulum (ER) signaling receptor involved in the type I interferon response to pathogen- or self-derived cytosolic double-stranded DNA. Excessive activation of STING is associated with many...
Yupeng Jiang,Yunke Zhu,Meiqi Shi et al.
Yupeng Jiang et al.
Seed dormancy and germination are dynamically regulated by abscisic acid (ABA), with transcription factor ABA INSENSITIVE 5 (ABI5) serving as a key repressor of germination under stress. Here, we identify QUIRKY (QKY), a MULTIPLE C2 DOMAIN ...
State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease [0.03%]
状态依赖性调制棘刺投射神经元控制帕金森病小鼠模型中的左旋多巴诱导的异动症
Shenyu Zhai,Qiaoling Cui,David Wokosin et al.
Shenyu Zhai et al.
In the later stages of Parkinson's disease, patients often manifest levodopa-induced dyskinesia (LID), compromising their quality of life. The pathophysiology underlying LID is poorly understood, and treatment options are limited. To move t...
Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation [0.03%]
病毒感染引发的APOBEC3在膀胱癌起始中的变(mut)突变作用
George H Hatton,Sally R James,Andrew S Mason et al.
George H Hatton et al.
Carcinogenesis in human urothelium is driven by a high burden of mutations caused by the antiviral "APOBEC3" (apolipoprotein B mRNA editing enzyme, catalytic subunit-like 3) cytosine deaminase enzymes; however, there is no established viral...
Centrin-POC5 inner scaffold provides distal centriole integrity for sperm flagellar assembly [0.03%]
中心体-POC5内支架通过维持精子鞭毛组装所需的远端中心体的完整性来促进精子鞭毛组装
Yutaka Takeda,Eriko Kajikawa,Jingwen Wang et al.
Yutaka Takeda et al.
Centrioles undergo marked transformations during spermatogenesis that are essential for sperm motility and male fertility. Despite their importance, the molecular mechanisms and ultrastructural dynamics underlying these transformations rema...