Erratum for the Research Article "Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism" by J. Krstic et al [0.03%]
J. Krstic等作者的题为“禁食通过p53依赖性代谢协同作用改善肝细胞癌的治疗效果”的研究论文的勘误表
Published Erratum
Science advances. 2025 Dec 5;11(49):eaed6515. DOI:10.1126/sciadv.aed6515 2025
Near-infrared MINFLUX imaging enabled by suppression of fluorophore blinking [0.03%]
通过抑制荧光淬灭实现的近红外MINFLUX成像
Chinmaya V Srambickal,Hanie M Esmaeeli,Joachim Piguet et al.
Chinmaya V Srambickal et al.
MINimal photon FLUXes (MINFLUX) offers nanometer localization precision, with lower fluorophore requirements than for other super-resolution microscopy (SRM) techniques. Nonetheless, low localization probabilities hamper its application, an...
Golgi-localized phosphatidylinositol 4-kinase β mediates Rab11a activation and trafficking to promote ciliogenesis [0.03%]
高尔基体定位的磷脂酰肌醇4-激酶β介导Rab11a激活及运输以促进纤毛发生
Liwen Wang,Jia Sun,Shuang Sun et al.
Liwen Wang et al.
Ciliogenesis requires an orchestrated interaction between the Golgi apparatus and centrioles via vesicle trafficking, yet this process is still poorly understood. Phosphatidylinositol 4-kinase β (PI4KB) is a conserved kinase that localizes...
T-SCAPE: T cell immunogenicity scoring via cross-domain aided predictive engine [0.03%]
基于跨域辅助预测引擎的T细胞免疫原性评价方法(T-SCAPE)
Jeonghyeon Kim,Nuri Jung,Jayyoon Lee et al.
Jeonghyeon Kim et al.
T cell immunogenicity, the ability of peptide fragments to elicit T cell responses, is a critical determinant of the safety and efficacy of protein therapeutics and vaccines. While deep learning shows promise for in silico prediction, the s...
Combined innate immune cell therapy, tumor-specific antibody, and radiation prompt antitumor response in pancreatic cancer models [0.03%]
联合先天免疫细胞治疗、肿瘤特异性抗体和放疗可促进胰腺癌模型的抗肿瘤反应
Md Mahfuzur Rahman,Andrea Pennati,Tavus Atajanova et al.
Md Mahfuzur Rahman et al.
Pancreatic ductal adenocarcinoma (PDAC) is generally resistant to conventional immunotherapies due to its immunosuppressive tumor microenvironment (TME). We combine an innate cell-enriched product activated by interleukin-2 (IL-2) and zoled...
A central CeA-LC-PVH circuit mediates stress-induced osteopenia via skeletal sympathetic nerves in male mice [0.03%]
雄性小鼠中央杏仁核-蓝斑-室旁核环路通过骨骼交感神经介导应激诱导的骨质疏松症
Wen-Jun Zhao,Yu-Xin Lu,Guo-Di Fan et al.
Wen-Jun Zhao et al.
Chronic stress disrupts skeletal homeostasis, yet central neural mechanisms remain unclear. In this study, we demonstrated that hyperactivation of locus coeruleus noradrenergic (LCNE+) neurons was both necessary and sufficient to drive bone...
Steric disruption of EGFR oligomerization overcomes therapy resistance in non-small cell lung cancer [0.03%]
表观遗传学药物联合免疫治疗可提高肿瘤免疫疗法的疗效
Daesun Song,Jaebong Jang,Michael Z Lin et al.
Daesun Song et al.
Acquired drug resistance mutations in epidermal growth factor receptor (EGFR) present a substantial clinical challenge in treating non-small cell lung cancer (NSCLC). While EGFR oligomerization plays a pivotal role in modulating receptor si...
Single-crystalline BaTiO3-based ferroelectric capacitive memory via membrane transfer [0.03%]
基于单晶BaTiO３铁电电容器的存储技术
Xinyuan Zhang,Sangho Lee,Jung-El Ryu et al.
Xinyuan Zhang et al.
Ferroelectric capacitive memory (FeCAP) holds enormous potential for low-power, high-density in-memory computing. While hafnia-based FeCAPs have attracted attention for their silicon compatibility, they suffer from limited performance, such...
Ultraselective sequestration of Li+ and Mg2+ from brines via a reusable polyoxoniobate-based ion sponge [0.03%]
一种可重复使用的多金属氧酸盐基离子海绵，能够从盐水中超选择性地富集锂离子和镁离子
Linfeng Chen,Chenyang Li,Sahand Adibnia et al.
Linfeng Chen et al.
Lithium (Li) and magnesium (Mg) are designated as critical mineral materials (CMM) due to their essential roles in clean energy technologies. However, extracting high-purity Li+ from brine remains a formidable challenge owing to the presenc...
Conservation of mRNA operon formation in control of the heat shock response in mammalian cells [0.03%]
哺乳动物细胞中控制热休克反应的mRNA操纵子形成的保守性
Emese Pataki,Jeffrey E Gerst
Emese Pataki
Prokaryotes use polycistronic transcription (operons) to express multiple messenger RNAs (mRNAs) from a single promoter to coexpress functionally related genes. However, how do eukaryotes, which express monocistronic messages, achieve the s...