Repair of female reproductive function by GDF-9-overexpressing extracellular vesicles via ACVR1B/SMAD2 regulation in ovarian granulosa [0.03%]
GDF-9过表达外泌体通过ACVR1B/SMAD2调控修复卵巢颗粒细胞女性生殖功能的恢复
Sichen Zhang,Huidong Liu,Tianyue Zhang et al.
Sichen Zhang et al.
Aging in females is characterized by dysfunctional ovaries (DOs). While human umbilical cord mesenchymal stem cell (HucMSC)-derived extracellular vesicles (EVs) have shown promise in ameliorating DO, the mechanisms underlying their effects ...
Disentangling participation in online political discussions with a collective field experiment [0.03%]
利用集体现场实验的方法探究线上政治讨论参与度的影响因素
Lisa Oswald,William Small Schulz,Philipp Lorenz-Spreen
Lisa Oswald
Online political discussions are often dominated by a small group of active users, while most remain silent. This visibility gap can distort perceptions of public opinion and fuel polarization. Using a collective field experiment on Reddit,...
Evaluating the effects of archaic protein-altering variants in living human adults [0.03%]
评估_archaic_蛋白质改变变异在活着的成人人体内的作用效应
Barbara Molz,Mikel Lana Alberro,Else Eising et al.
Barbara Molz et al.
Advances in paleogenetics allowed the identification of protein-coding changes unique to Homo sapiens by comparing present-day and archaic hominin genomes. So far, experimental validation has been restricted to functional assays and model o...
Unlocking megawatt-peak-power laser emission with colloidal quantum dots [0.03%]
解密兆瓦级峰值功率激光发射的胶体量子点技术
Yuting Wu,Hancheng Zhu,Zhigao Huang et al.
Yuting Wu et al.
Output power of a laser device critically defines the application prospects. Colloidal quantum dots (QDs) have emerged as auspicious laser media; however, the exclusively low-power emission obscures the practical deployment. Here, we resolv...
Yuye Huang,David O&#x;Connor,Bailey B Harris et al.
Yuye Huang et al.
Cortisol is known to promote memory for emotionally arousing experiences, yet the neural networks involved in enhancing these memories are unknown. Here, we combine pharmacological fMRI with an analysis approach to determine the dynamic bra...
Unusual inheritance of a functional cki homolog in the human pathogen Schistosoma mansoni [0.03%]
曼森血吸虫中功能性CKI同源物的特殊遗传方式
George R Wendt,James J Collins rd
George R Wendt
Schistosomes, parasitic flatworms responsible for the neglected tropical disease schistosomiasis, are protected by a skin-like tegument, and tegument maintenance is controlled by a schistosome ortholog (p53-1) of the tumor suppressor TP53. ...
Deep-blue light-emitting diodes based on perovskite single-crystal thin films [0.03%]
基于钙钛矿单晶薄膜的深蓝色发光二极管
Danlei Zhu,Yifan Zhou,Xu Wen et al.
Danlei Zhu et al.
Metal halide perovskite light-emitting diodes (LEDs) are transformative optoelectronic platforms due to their tunable emission, high color purity, and broad color gamut. Nevertheless, the realization of high-luminance blue LEDs, particularl...
Outcompeting hydrofunctionalization: Asymmetric remote substitution of alkynes [0.03%]
超越氢官能团化反应：炔烃的不对称远程取代反应
Yi-Xiao Shen,Chao Ma,Guo-Qiang Lin et al.
Yi-Xiao Shen et al.
Propargylic substitution is a broadly studied basic reaction but requires a vicinal leaving group in the alkyne substrate. Here, we describe the first asymmetric remote substitution of alkynes bearing a linear alkyl-linked remote leaving gr...
Insect-inspired micro-optical antenna enables ultrasensitive multisensory perception [0.03%]
昆虫启发的微光学天线实现超灵敏多模感知
Xitao Tu,Chen Qian,Tao Feng et al.
Xitao Tu et al.
Insects have evolved highly optimized antennae with ultrasensitive tactile, auditory, and olfactory senses. Although imitating insect antennae offers a promising route to achieving advanced sensing abilities, developing a micro-sized artifi...
A mechano-gated ionic diode enables low-power synaptic tactile spiking [0.03%]
机械门控离子二极管实现低功耗突触体感触发脉冲
Yong Min Kim,Hanbin Choi,Ji Hong Kim et al.
Yong Min Kim et al.
Ionic diodes, which enable unidirectional ion transport, hold great promise for adaptive and energy-efficient ionotronic systems. However, conventional designs often rely on high ion concentrations, which promote ion pairing and clustering,...