Cold-air outbreaks in the continental US: Connections with stratospheric variations [0.03%]
北美大陆冷空气爆发与平流层变化的联系
Laurie Agel,Judah Cohen,Mathew Barlow et al.
Laurie Agel et al.
Mid-latitude Northern Hemisphere extreme cold events continue to occur despite overall winter warming trends. These events have been linked to weakened stratospheric polar vortex (SPV) states. In this study, we analyze both the upper and lo...
Domain engineering in ferroelectric nematics for nonlinear optical modulation [0.03%]
用于非线性光学调制的铁电尼龙中的领域工程学
Chao-Yi Li,Xiao-Yi Xu,Jidan Yang et al.
Chao-Yi Li et al.
Domain engineering is essential in ferroelectric materials for controlling polar properties and attracts considerable attention because of its induced exotic phenomena and underlying rich physics. In recently discovered fluid ferroelectrics...
Dynamically covalent lipid nanoparticles mediate CRISPR-Cas9 genome editing against choroidal neovascularization in mice [0.03%]
动态共价脂质纳米颗粒介导CRISPR-Cas9基因编辑以治疗小鼠的脉络膜新生血管形成
Desheng Cao,Junliang Zhu,Yang Guo et al.
Desheng Cao et al.
As an important modality for choroidal neovascularization (CNV) treatment, intravitreal injection of vascular endothelial growth factor A (VEGFA) inhibitors suffers from undesired response rate, low patient compliance, and ocular damage. He...
Parallel evolution of salinity tolerance in Arabidopsis thaliana accessions from Cape Verde Islands [0.03%]
加那利群岛拟南芥品系耐盐性状的并行进化研究
Félix J Martínez Rivas,Dorothee Wozny,Zeyun Xue et al.
Félix J Martínez Rivas et al.
Soil salinization poses a notable threat to agriculture. The Cape Verde Islands are located 600 km off the coast of Africa and are characterized by arid environments and high-salinity soils. Here, we find that Arabidopsis thaliana plants na...
Transition of cellular senescence to pyroptosis mediates recurrence of small cell lung cancer after chemotherapy [0.03%]
化疗后小细胞肺癌复发的机制研究：衰老细胞向焦亡细胞转化模型
Lie Ma,Yu Han,Zixin Chen et al.
Lie Ma et al.
Chemotherapy-induced different cell fates play crucial roles in cancer treatment outcomes; however, the cross-talk between the cell fates during cancer recurrence remains unclear. Here, we found that the transition from cellular senescence ...
Complex I inhibition combined with TLR activation in the breast tumor microenvironment educates cytotoxic neutrophils [0.03%]
乳腺肿瘤微环境中的复杂I型抑制结合TLR活化教育细胞毒性中性粒细胞
John Heath,Ryuhjin Ahn,Valerie Sabourin et al.
John Heath et al.
Although effective for immunologically hot tumors, immune checkpoint inhibitors minimally affect tumors that are not T cell inflamed, including breast cancer. An alternate strategy to combat immune cold breast tumors may be to reeducate inn...
Exogenous activation of the adhesion GPCR ADGRD1/GPR133 protects against bone loss by negatively regulating osteoclastogenesis [0.03%]
外源激活黏附G蛋白偶联受体ADGRD1/GPR133通过抑制破骨细胞生成防治骨丢失
Liang He,Qiansen Zhang,Yu You et al.
Liang He et al.
Adhesion G protein-coupled receptors (GPCRs) play crucial roles in numerous physiological and pathological conditions. However, the functions of adhesion GPCRs remain poorly understood because of the lack of effective modulators. Here, we u...
Guido M Gianni,Leandro C Gallo,Jeremías Likerman et al.
Guido M Gianni et al.
Flat subduction, an intermittent phenomenon along active margins, arises from well-known causes, yet the mechanisms driving its expansion remain poorly understood. The prevailing view suggests that trenchward continental motion drives slab ...
Constraining biorecalcitrance of carboxyl-rich alicyclic molecules in the ocean [0.03%]
约束海洋中羧基丰富的脂环族分子的生物惰性
Ruanhong Cai,Oliver J Lechtenfeld,Zhenwei Yan et al.
Ruanhong Cai et al.
Marine dissolved organic matter (DOM) is one of Earth's largest long-term carbon reservoirs, critical to the global carbon cycle. A key breakthrough in understanding this pool is the identification of biorefractory carboxyl-rich alicyclic m...
BRD4770 protects against DOX-induced cardiotoxicity by inhibiting apoptosis and ferroptosis [0.03%]
BRD4770通过抑制凋亡和铁死亡防治多柔比星诱发的心脏毒性
Jingrong Shao,Rui Xiao,Ting Wang et al.
Jingrong Shao et al.
Doxorubicin (DOX) is an effective anticancer drug, but its clinical utility is limited mainly by cardiotoxicity causing cardiomyocyte ferroptosis and apoptosis. While DOX-induced cardiotoxicity (DIC) involves epigenetic changes, no systemat...