UFMylation maintains tumor suppressor pVHL stability by activating the deubiquitinase BAP1 [0.03%]
泛素特异性蛋白酶BAP1去泛素化稳定肿瘤抑制因子pVHL
Xiao Yang,Yalei Wen,Shengying Qin et al.
Xiao Yang et al.
BRCA1-associated protein 1 (BAP1) can function as a tumor suppressor or oncogene depending on context, but its role in colorectal cancer (CRC) is not well understood. Here, we demonstrate that BAP1 suppresses CRC progression primarily by de...
Polymer encapsulation via initiated chemical vapor deposition (iCVD) to enhance stability of Ti3C2T x MXene-based formaldehyde sensors [0.03%]
通过引发化学气相沉积(iCVD)对Ti3C2T x MXene基甲醛传感器的聚合物封装以增强其稳定性
Shwetha Sunil Kumar,Renuka H,Nicholas Hattrup et al.
Shwetha Sunil Kumar et al.
MXene is a class of compounds known for its superior electrical properties and versatile surface chemistries. However, its susceptibility to oxidation-induced degradation under ambient conditions prevents its incorporation into devices. In ...
G proteins of the G12 family expressed by POMC neurons regulate key metabolic functions [0.03%]
由POMC神经元表达的G12家族G蛋白调节关键代谢功能
Dhanush Haspula,Zhenzhong Cui,Srinivas Pittala et al.
Dhanush Haspula et al.
Proopiomelanocortin (POMC) neurons play a key role in maintaining glucose and energy homeostasis. POMC neurons express many heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors that are linked to different functio...
Atlantification drives recent strengthening of the Arctic overturning circulation [0.03%]
大西洋的影响导致最近北极翻转环流的加强
Marius Årthun,Ailin Brakstad,Jakob Dörr et al.
Marius Årthun et al.
The Arctic Ocean is the northern terminus of the Atlantic Meridional Overturning Circulation (AMOC), whose dense water masses are key to the global ocean circulation. The Arctic climate is rapidly changing, and it is not known how the Arcti...
Picoeukaryote-based biohybrid microrobots for active delivery in the kidney [0.03%]
基于微藻的生物杂化微型机器人在肾脏中的主动递送
Zhengxing Li,Dan Wang,Hao Luan et al.
Zhengxing Li et al.
Confined spaces in the human body pose substantial challenges for biomedical procedures. Navigating these ultrasmall environments is essential for precise drug delivery, improving treatment outcomes and reducing adverse effects. Microrobots...
A salt-driven mechanism for precise chirality sorting of carbon nanotubes [0.03%]
一种盐驱动的碳纳米管手性精准分离机制
Min Lyu,Cheng Li,Yanzhao Liu et al.
Min Lyu et al.
Sorting single-wall carbon nanotubes (SWCNTs) by chirality/handedness is of substantial scientific and technological importance. Existing sorting methods often lack simplicity, reproducibility and scalability. Here, we demonstrate a salt-dr...
Cypin regulates K63-linked polyubiquitination to shape synaptic content [0.03%]
Cypin通过调节K63连接的多泛素化来调控突触内容
Srinivasa R Gandu,Ana R Rodriguez,Jared Lamp et al.
Srinivasa R Gandu et al.
An open question in neuroscience is how protein posttranslational modifications regulate synaptic site targeting. Polyubiquitination plays a role in proteasome-mediated protein turnover; however, additional functions for specific types of p...
Structures and receptor binding activities of merbecovirus spike proteins reveal key signatures for human DPP4 adaptation [0.03%]
冠状病毒S蛋白结构及其受体结合活性揭示了人DPP4受体适应的关键位点签名特征
Hang Yuan,Jingjing Wang,Yong Ma et al.
Hang Yuan et al.
Merbecoviruses from bats, pangolins, and hedgehogs pose significant zoonotic threats, with a limited understanding of receptor binding by their spike (S) proteins. Here, we report cryo-EM structures of GD-BatCoV (BtCoV-422) and SE-PangolinC...
Weiyi Li,Stephan Baehr,Michelle Marasco et al.
Weiyi Li et al.
Although transcript-error rates are markedly higher than DNA-level mutation rates, a broad perspective on the degree to which they diverge across lineages remains to be developed. Using modified rolling-circle sequencing, we found a narrow ...
Structural and genetic determinants of zebrafish functional brain networks [0.03%]
斑马鱼功能大脑网络的结构和遗传决定因素
Antoine Légaré,Mado Lemieux,Vincent Boily et al.
Antoine Légaré et al.
Network science has revealed universal brain connectivity principles across species. However, several macroscopic network features established in human neuroimaging studies remain underexplored at cellular scales in small animal models. Her...