Preemptive cardioprotection with a small molecule in rodents that suppresses genes predictive of heart failure [0.03%]
一种小分子在啮齿类动物中抑制心脏衰竭基因的抢先性心肌保护作用
Yue Li,Matthew V Andrews,David T Humphreys et al.
Yue Li et al.
Ischemic heart disease is a leading cause of death worldwide. While percutaneous coronary intervention (PCI) restores blood flow in acute coronary syndrome (ACS), reperfusion injury exacerbates myocardial damage, contributing to heart failu...
Dynamic lattice disorder overrides energetics for barrierless interfacial charge transfer in 2D hybrid perovskites [0.03%]
二维杂化钙钛矿中动态晶格无序量超越了无能垒界面对电荷转移的能量效应
Tianjing Li,Haoran Lu,Ming Xia et al.
Tianjing Li et al.
Two-dimensional (2D) hybrid perovskites show promise in charge transfer (CT) applications, yet how their inherent dynamic lattice disorder redefines the CT dynamics remains unresolved. Using tetrathiophene-based 2D perovskites 4Tm2MAn-1PbnI...
Mid-late Pleistocene evolution of fluvial landscapes in Central Amazonia: Shaping ecosystems and areas of endemism [0.03%]
中亚马逊地区中更新世至晚更新世河流景观演化：生态系统和特有物种分布区的形成
Cristiano P Galeazzi,Renato P Almeida,Carlos E E Mazoca et al.
Cristiano P Galeazzi et al.
The influence of Amazonian rivers and landscape changes on species origin and distribution remains debated. Here, we combine sedimentary, geomorphological, and chronological evidence from Central Amazonia to show that the main Amazonian riv...
Evans Eshriew,Esa-Pekka Kumpula,Shiv K Sah-Teli et al.
Evans Eshriew et al.
Gap junction plaques (GJPs) enable direct intercellular communication and consist of connexin channels arranged into two-dimensional lattices. While structures of purified connexin channels have informed models of gating, they omit key intr...
Zhou Zhou,Shihao Wang,Wen Wen et al.
Zhou Zhou et al.
Nanoscale lasers with low thresholds and on-demand structured light output are essential for compact integrated photonic technology. Introducing engineered disorder into high quality-factor (Q) resonant cavities emerges as a promising route...
Quantifying 3D live-cell membrane dynamics using dynamic metal-induced energy transfer spectroscopy (dynaMIET) [0.03%]
基于动态金属诱导能量转移光谱法的三维活细胞膜动力学量化方法研究
José Ignacio Gallea,Narain Karedla,Dongxia Wang et al.
José Ignacio Gallea et al.
The dynamic behavior of cellular membranes underpins essential biological processes, including signal transduction, intracellular trafficking, and mechanotransduction. However, simultaneously quantifying lateral molecular diffusion and vert...
A pioneering plastic particle footprint concept for addressing the challenges posed by plastic pollution [0.03%]
一种开创性的塑料颗粒概念足迹，以应对塑料污染带来的挑战
Valérie Guillard,Elisa Chapuis,Joshua Sohn et al.
Valérie Guillard et al.
Persistent plastic micro- and nanoparticle (MNP) pollution poses a serious threat to global health. Yet they typically cannot be considered in conventional life cycle assessments (LCAs), which weakens decision-making. To avoid waiting for c...
PPT1 selectively depalmitoylates GAP43 to regulate neuronal excitability and cognitive function [0.03%]
PPT1通过选择性脱棕榈酰化GAP43调节神经元兴奋性和认知功能
Jia Tong,Yang Liu,Wanliu Wu et al.
Jia Tong et al.
Palmitoylation is a reversible lipid modification, regulating protein localization and signaling in neurons. Growth-associated protein 43 (GAP43) requires palmitoylation for axonal development and synaptic plasticity; however, its depalmito...
Zwitterionic carbamate interfaces unlock efficient "liquid" CO2 upgrading [0.03%]
zwitter离子性碳酸酯界面可实现高效的“液态”二氧化碳升级转化
Yitong Li,Peng Li,Yiwen Zhong et al.
Yitong Li et al.
Integrating carbon dioxide (CO2) capture with its direct electrochemical conversion remains a major challenge for sustainable energy technologies. Although amine scrubbing is widely used for CO2 capture, its integration with electrochemical...
Open and closed forms of assembled henipavirus nucleoprotein suggest structural basis of genome access [0.03%]
组装人nip病毒核酸蛋白的开放和闭合形式表明了基因组访问的结构基础
Rupesh Balaji Jayachandran,Erwan Quignon,Max Renner
Rupesh Balaji Jayachandran
Henipaviruses, such as Nipah virus, can cause deadly illness and constitute WHO blueprint priorities due to their pandemic potential. Their genomes are packaged within a nucleocapsid consisting of viral nucleoproteins (N). Now, it is unclea...