A Poppy Roworth,Fatemeh Ghari,Nicholas B La Thangue
A Poppy Roworth
The E2F1 transcription factor is a recognized regulator of the cell cycle as well as a potent mediator of DNA damage-induced apoptosis and the checkpoint response. Understanding the diverse and seemingly dichotomous functions of E2F1 activi...
Cédric Rébé,Valentin Derangère,François Ghiringhelli
Cédric Rébé
Liver X receptors (LXRs) have been proposed to have some anticancer properties. We recently identified a new non-genomic role of LXRβ in colon cancer cells. Under LXR agonist treatment, LXRβ induces pyroptosis of these cells in vitro and ...
The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks [0.03%]
PBAF染色质重塑复合物可在DNA双链断裂处抑制转录并促进快速修复
Andreas Kakarougkas,Jessica A Downs,Penny A Jeggo
Andreas Kakarougkas
Transcription in the vicinity of DNA double-strand breaks (DSBs) is suppressed via a process involving ataxia telangiectasia mutated protein (ATM) and H2AK119 ubiquitylation.(1) We discuss recent findings that components of the Polybromo an...
Kevin J Barnum,Matthew J O&#x;Connell
Kevin J Barnum
DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recogniti...
Valentina Cianfanelli,Francesca Nazio,Francesco Cecconi
Valentina Cianfanelli
During autophagy, a double-membraned vesicle called the autophagosome is responsible for the degradation of long-lived proteins and damaged/old organelles, thus contributing to the maintenance of cellular homeostasis. Physiological stimuli ...
DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis [0.03%]
双面激酶DYRK1A在细胞生长和肿瘤发生中的作用
P Fernández-Martínez,C Zahonero,P Sánchez-Gómez
P Fernández-Martínez
DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications for embryonic development, especially in the nervous system where it regulates the balance between proliferation and differentiation of neural pro...
Qingchun Cai,Yan Xu
Qingchun Cai
In the course of multistep oncogenesis, initially normal cells acquire several new functions that render them malignant. We have recently demonstrated that the peritoneal microenvironment promotes resistance to anoikis in ovarian cancer cel...
Adam M Schmitt,Bakhtiar Yamini
Adam M Schmitt
NF-κB proteins play a complex role in modulating carcinogenesis following DNA damage. Previous work identified p50/NF-κB1 as a necessary factor in the cytotoxic response to alkylation damage. Recently, these findings were extended to demo...
Tinke L Vormer,Jacob B Hansen,Hein Te Riele
Tinke L Vormer
Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). T...
Yongjoon Suh,Su-Jae Lee
Yongjoon Suh
The mechanism underlying KRAS (Kirsten rat sarcoma viral oncogene homolog)-driven cellular transformation remains unclear because of the complexity of its downstream effectors. Park et al. recently reported that levels of reactive oxygen sp...