Loss of Schwann cell's normal rhythmic core clock gene expression and gain of rhythmic expression of oncogenic driver genes in malignant NF1-associated peripheral nerve sheath tumor [0.03%]
NF1相关恶性外周神经鞘瘤中施万细胞正常昼夜节律核心基因表达的丧失和致癌驱动基因节律表达的获得
Sandra Leisz,Antonio Pelligrino,Saskia Fritzsche et al.
Sandra Leisz et al.
Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor syndrome caused by pathogenic variants in the NF1 gene. Beside tumor formation, patients often have sleep disturbances, suggesting circadian involvement. Previous NF1 studies hav...
Cytokeratin expression in breast cancer: from mechanisms, progression, diagnosis, and prognosis to therapeutic implications [0.03%]
乳腺癌中细胞角蛋白的表达：从机制、进展、诊断和预后到治疗意义
Ensiyeh Bahadoran,Sahar Moghbelinejad,Ghazaleh Mohammadi et al.
Ensiyeh Bahadoran et al.
Background and aim: Cytokeratins (CKs) are structural proteins vital to epithelial integrity and play key roles in breast cancer progression. This review explores their expression, functions, and therapeutic potential. ...
TRIM22 promotes glioblastoma development by ubiquitinating Bcl-2 [0.03%]
TRIM22通过泛素化Bcl-2促进胶质母细胞瘤的发生发展
Jiahao Zhang,Yuning Chen,Gaosong Wang et al.
Jiahao Zhang et al.
Glioblastoma (GBM) exhibits elevated TRIM22 expression correlated with tumor progression, as validated in TCGA/GEO databases. The effects of TRIM22 knockdown and overexpression on GBM proliferation were evaluated with cellular assays. TRIM2...
The Role of V-ATPase ATP6V0D1 Subunit in Chemoresistance and Ellipticine-Induced Cytoplasmic Vacuolation in Neuroblastoma Cells [0.03%]
神经母细胞瘤细胞中V-ATP酶ATP6V0D1亚基在化疗耐药及椭圆素诱导的胞浆空泡化中的作用
M Rychla,J Hrabeta,P Jencova et al.
M Rychla et al.
Drug resistance remains a major obstacle in neuroblastoma treatment. Lysosomal sequestration, facilitated by the V-ATPase proton pump, is one of the mechanisms of chemoresistance. Overexpression of the ATP6V0D1 subunit of V-ATPase, previous...
GSTP1 knockdown induces metabolic changes affecting energy production and lipid balance in pancreatic cancer cells [0.03%]
GSTP1敲除诱导出影响胰腺癌细胞能量生成和脂质平衡的代谢变化
Jenna N Duttenhefner,Katie M Reindl
Jenna N Duttenhefner
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options, underscoring the need for novel therapeutic targets. Metabolic reprogramming is a hallmark of PDAC, enabling tumor cells to sustain rapid prolif...
Increased MLH1, MGMT, and p16INK4a methylation levels in colon mucosa potentially useful as early risk marker of colon cancer [0.03%]
结肠黏膜中MLH1、MGMT和p16INK4a的甲基化水平升高可作为结肠癌早期风险标记物
Yvonne Wettergren,Peter Rolny,Helena Lindegren et al.
Yvonne Wettergren et al.
The genes MutL Homolog 1 (MLH1), O6-methylguanine-DNA methyltransferase (MGMT), and cyclin-dependent kinase inhibitor p16INK4a are commonly downregulated by hypermethylation in colorectal cancer. Long interspersed nucleotide element 1 (LINE...
CHK1 inhibition overcomes gemcitabine resistance in non-small cell lung cancer cell A549 [0.03%]
CHK1抑制可克服非小细胞肺癌A549细胞中吉西他滨的耐药性
Zhi-Yin Ke,Tian Fu,Xue-Chun Wang et al.
Zhi-Yin Ke et al.
The purpose of the study is mainly to investigate anti proliferation of non-small cell lung cancer A549 cells and its mechanism by inhibition of CHK1 expression combined with gemcitabine. The mRNA and protein levels of genes were analyzed b...
The immunopeptidome of colon cancer cells treated with topoisomerase inhibiting drug reveals differential as well as common endogenous protein sampling and display of MHC I-associated peptides [0.03%]
使用拓扑异构酶抑制药物处理的结肠癌细胞的免疫肽组揭示了MHC I相关肽类的不同以及共同的内源性蛋白采样和展示
Deepa Bedi,Mohammed Hassan,Alehegne Yirsaw et al.
Deepa Bedi et al.
Immunotherapy options for microsatellite stable (MSS) colorectal cancer are currently very limited. The lack of detectably unique or altered immunogens in the tumor microenvironment may be a factor. Radiation and chemotherapy may enhance im...
METTL14-mediated m6A modification upregulates HOXB13 expression to activate NF-κB and exacerbate cervical cancer progression [0.03%]
METTL14介导的m6A修饰通过上调HOXB13表达激活NF-κB并加重宫颈癌进展
Qian Li,Na Zhao,Xuejing Ding et al.
Qian Li et al.
Cervical cancer (CC) is one of the common malignant tumors in women, and the incidence rate is located in the second place of female tumors. As a major RNA N6-methyladenosine (m6A) methyltransferase, methyltransferase-like 14 (METTL14) is i...
An antibody-drug conjugate for endometrioid carcinoma based on the expression of cell adhesion molecule 1 [0.03%]
基于细胞粘附分子1表达的抗体药物偶联物治疗子宫内膜样癌研究进展
Man Hagiyama,Azusa Yoneshige,Tomoyuki Otani et al.
Man Hagiyama et al.
Cell adhesion molecule 1 (CADM1), an immunoglobulin superfamily member, is expressed in endometrial glandular cells highly during the proliferative phase but lowly during the secretory phase. Previously, a CADM1-targeting antibody-drug conj...