Isolation of small extracellular vesicles by interacting with inorganic surface [0.03%]
通过与无机表面相互作用分离小型细胞外囊泡
Satoe Obuchi,Masamune Morita,Goshi Kuno et al.
Satoe Obuchi et al.
Extracellular vesicles (EVs) have great potential as diagnostic and therapeutic tools because they are important mediators of intercellular communication. Although several EV isolation methods have been developed, efficient and selective is...
Immune synapse molecules knockout in induced pluripotent stem cells enables broad NK cell resistance in T cell progeny [0.03%]
诱导多能干细胞中免疫突触分子敲除使T细胞后代广谱的NK细胞抵抗性
Jing Zhang,Keisuke Sumide,Keitaro Kanie et al.
Jing Zhang et al.
Introduction: Allogeneic iPSCs provide a potential source for regenerative T cell therapies, yet their clinical application remains limited by immune rejection driven by human leukocyte antigen (HLA) incompatibility. Knoc...
Frida Velcani,Erica Keyes,José Luis Caraveo rd et al.
Frida Velcani et al.
Introduction: Regenerative medicine involves restoring natural function by replacing or regenerating human cells, tissues, or organs. Despite projections of significant market growth, venture capital (VC) investment in ti...
Low-frequency electromagnetic fields ameliorate testosterone-induced androgenetic alopecia in mice through LncRNA H19/miR-214-5p/β-catenin signal pathway [0.03%]
低频电磁场通过LncRNA H19/miR-214-5p/β-catenin信号通路改善小鼠雄激素性脱发的研究
Jiang-Hua Cheng,Chong-You,Ting Hu et al.
Jiang-Hua Cheng et al.
Background: In androgenetic alopecia (AGA), the depletion or long-term inactivity of the hair follicle stem cells (HFSCs) pool is a fundamental cause. Reviving inactive HFSCs is regarded as a promising treatment method fo...
The favorable role of recombinant collagen peptide in periosteal cell-derived osteoregeneration [0.03%]
重组胶原肽在骨膜细胞源性成骨再生中的积极作用
Tran Thi Thuy Diep,Naoki Takahashi,Takahiro Tsuzuno et al.
Tran Thi Thuy Diep et al.
Background: Human periosteal cells (hPCs) possess high osteogenic potential and are considered promising candidates for regenerative therapy. Recombinant human collagen peptide (RCP), a xeno-free biomaterial enriched with...
First-in-human study to investigate the safety and efficacy of effective-mononuclear cell therapy for radiogenic xerostomia [0.03%]
人源性第一试验研究辐射所致口腔干燥的有效单核细胞治疗的安全性和疗效
Takashi I,Mayumi Iwatake,Takako Yoshida et al.
Takashi I et al.
Background: Salivary gland (SG) hypofunction is the most common complication following radiotherapy for head and neck cancer. Currently, there are no effective therapies for radiation-induced xerostomia. We recently devel...
In vitro polarized macrophages ameliorate adverse cardiac remodeling in a mouse model of transverse aortic constriction [0.03%]
体外诱导极化的巨噬细胞改善了胸主动脉缩窄小鼠模型的不良心脏重塑
Ulugbek Yakhshimurodov,Kizuku Yamashita,Takuji Kawamura et al.
Ulugbek Yakhshimurodov et al.
Introduction: Heart failure (HF) caused by pressure overload remains as one of the leading causes of morbidity and mortality worldwide, which can manifest itself in a wide range of clinical scenarios. Current therapeutic ...
Extracellular vesicles derived from adipose-derived mesenchymal stem/stromal cells prevent synovial inflammation and attenuate cartilage degeneration in rodent osteoarthritis [0.03%]
来源于脂肪来源的间充质干细胞/基质细胞的细胞外囊泡可预防啮齿动物骨关节炎滑膜炎症和软骨退变
Yushi Maruiwa,Yasuo Niki,Yo Mabuchi et al.
Yushi Maruiwa et al.
Objective: Osteoarthritis (OA) is the most common joint disease in the elderly and a major cause of pain and disability. Recent advances in OA therapy have led to a greater variety of treatment options. Extracellular vesi...
Low-dose lipopolysaccharide pretreatment enhanced the proliferation and antibacterial activity of human adipose-derived mesenchymal stem cells [0.03%]
低剂量脂多糖预处理可增强人脂肪源性间充质干细胞的增殖和抗菌活性
Linling Li,Jielin Diao,Feng Wang et al.
Linling Li et al.
Introduction: Adipose-derived mesenchymal stem cells (ADSCs) have been widely investigated for their pro-angiogenic and immunomodulatory roles in the repair of infected wounds. However, the direct antimicrobial effects of...
Mesenchymal stromal cell-derived extracellular vesicles in regenerative medicine: Standardisation, bioengineering and clinical translation [0.03%]
再生医学中的间充质基质细胞源性外泌体：标准化、生物工程和临床转化
Yusuke Shimizu,Yoshikazu Inoue,Naoki Matsuura et al.
Yusuke Shimizu et al.
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have emerged as promising cell-free therapeutics that recapitulate key paracrine functions of MSCs whilst mitigating limitations of viable-cell therapies. Clinical translatio...